Abstract:
:The histology of free microvascular muscle flaps in 19 patients was studied prospectively. Biopsies were taken during operation, and after 2 and 6 weeks, as well as 3, 6, and 9 months, postoperatively, fixed and stained using the van Gieson method. Fiber diameters were analyzed morphometrically and fiber types defined immunohistochemically using myosin fast antibody. During the nine-month follow-up period, mean muscle fiber diameter decreased significantly (P < 0.01), type-1 fibers atrophied significantly (P < 0.05) compared to type-2 fibers, and the percentage of type-2 fibers increased from a mean of 56% intraoperatively to 73% at 9 months. Fatty change and fibrosis were already present 2 weeks after operation and increased with the duration of follow-up. The decrease in muscle fiber diameter 9 months after free flap transfer correlated with clinical factors such as the delay of reconstructive surgery, recipient site, postoperative infection, and postoperative immobilization. The present results confirm that type-specific atrophy related to denervation appears and indicates that clinical events other than denervation influence the muscle atrophy seen in human free muscle flaps. These findings focus attention on the role of muscle regeneration, reinnervation, and revascularization taking place after free flap transfer.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Kauhanen MS,Salmi AM,von Boguslawsky EK,Leivo IV,Asko-Seljavaara SLdoi
10.1002/(sici)1098-2752(1998)18:2<137::aid-micr13>subject
Has Abstractpub_date
1998-01-01 00:00:00pages
137-44issue
2eissn
0738-1085issn
1098-2752pii
10.1002/(SICI)1098-2752(1998)18:2<137::AID-MICR13>journal_volume
18pub_type
临床试验,杂志文章相关文献
MICROSURGERY文献大全abstract::We tested the hypothesis that the intrinsic vascular plexus of the motor nerve could support viability in a rat hindlimb muscle flap. In a preliminary study, we examined the course and vascularity of the sciatic nerve, the peroneal nerve, and the peroneous longus muscle in the rat hindlimb via anatomic dissection, mic...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.20609
更新日期:2009-01-01 00:00:00
abstract::Regulation of capillary permeability with ischemic reperfusion injury is a complex interaction between vascular endothelium and circulating blood factors. Corticotropin-releasing factor (CRF), a 41 -amino acid peptide CNS neurotransmitter known to modulate the pituitary-adrenal axis during stress response, has been sh...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/(sici)1098-2752(1998)18:2<76::aid-micr3>3.
更新日期:1998-01-01 00:00:00
abstract::The potential for hyperbaric oxygen therapy (HBO) to decrease the untoward effects of a secondary ischemic event was studied in the rat superficial epigastric flap model. The secondary venous ischemic flap was created by cross-clamping the vascular pedicles for 2 h. Twenty-four hours later, the flap was reelevated and...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.21723
更新日期:2002-01-01 00:00:00
abstract::An experimental animal model of a vascularized graft is presented as an alternative to recover faster function. The technique is described and the model compared to a conventional graft in the sciatic nerve of a rabbit. Results are evaluated with histological studies and quantified using a computer to measure the thic...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920060205
更新日期:1985-01-01 00:00:00
abstract::Transplants of the cranial portion of the dog sartorius muscle were able to generate 70% of control force after 3 months if the artery, vein, and nerve were reanastomosed. Our histological and histochemical findings correlate with the functional findings. In a separate group of animals that had their muscles denervate...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920070302
更新日期:1986-01-01 00:00:00
abstract::This study reviewed our experience with the gracilis myocutaneous (GMC) flap, potential risk factors for flap necrosis, and long-term morbidity at the donor-site. From 1993 to 2002, 29 GMC flaps were harvested from 27 patients (pedicled n = 21 and free n = 8). The overall incidence of flap necrosis was 13.79% (partial...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.20899
更新日期:2011-09-01 00:00:00
abstract:INTRODUCTION:Calcaneal tumors being a rare occurrence, surgical options and outcomes are not well-known. Extensive defects following wide resection, especially in weight-bearing areas, still remain a challenge and different reconstructive techniques have been proposed. The aim of this report was to analyze the clinical...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.30452
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Reconstructing soft tissue defect on the trochanteric area is challenging. Due to the significant complications associated with regional flap, free tissue transfer is an appropriate option. However, this area has poor recipient vessels. Therefore, we present perforators as suitable recipient vessels to facil...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.30424
更新日期:2020-01-01 00:00:00
abstract::The purpose of this report is to show that customized component second-toe transfers may improve functional and aesthetic outcomes following bone, soft tissue, and joint destruction of traumatically injured digits. A 22-year-old male sustained a planer injury resulting in loss of the distal volar soft tissues of the m...
journal_title:Microsurgery
pub_type:
doi:10.1002/micr.30411
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:The purpose of this study was to consider the relationship between the ratio of deep tissue including muscle to thigh at donor sites and the possibility of performing primary closure of donor site. METHODS:The subjects were 74 patients who had harvesting of anterolateral thigh (ALT) free flap from June 2005 to...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.22080
更新日期:2013-05-01 00:00:00
abstract::Regeneration of the rat sciatic nerve was studied after a crush lesion (test lesion) on nerves previously subjected to a conditioning lesion. The test lesion was made approximately 30 mm proximal to the conditioning lesion. The period between the conditioning lesion and the test lesion was varied. Regeneration was mea...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920100210
更新日期:1989-01-01 00:00:00
abstract::We present an easily constructed devise, which allows the testing and comparison of microsurgical apparatus, providing a numerical result for statistical analysis. It also enables the trainee microsurgeon to practise basic microsurgical skills in a safe environment. Construction and uses are discussed. ...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/(sici)1098-2752(1998)18:7<430::aid-micr8>3
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:Currently, increasingly reconstructive surgeon consider the failure rates of perforator propeller flaps especially in the distal third of the lower leg are too important and prefer to return to the use of free flap at first line option with failure rates frequently lower than 5%. So, we performed a systema...
journal_title:Microsurgery
pub_type: 杂志文章,meta分析,评审
doi:10.1002/micr.30047
更新日期:2018-01-01 00:00:00
abstract::The feasibility of peripheral nerve allograft pretreatment utilizing cold storage (5 degrees C in the University of Wisconsin Cold Storage Solution) or freeze-thawing to prevent rejection was investigated. Regeneration across cold-stored (3 or 5 weeks) or freeze-thawed (FT), 3.0-cm sciatic nerve allografts were compar...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/(sici)1098-2752(1999)19:3<115::aid-micr1>3
更新日期:1999-01-01 00:00:00
abstract:UNLABELLED:The purpose of the study was to evaluate the fate of the digital arterial anastomoses, resting total digit blood flow, and cold-induced discomfort following digital replantation with two repaired arteries. The evaluation was done with a Doppler ultrasound of the anastomoses, temperature recording from the fi...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920160304
更新日期:1995-01-01 00:00:00
abstract::To evaluate the natural course of postsurgical adhesion formation, a descriptive animal study was performed in a standardized rat adhesion model, involving the uterine horn and peritoneal side wall. Extent and type of postsurgical adhesion formation was evaluated at increasing postoperative time intervals up to 1 year...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920160912
更新日期:1995-01-01 00:00:00
abstract::Many techniques have been developed for the evaluation of peripheral nerve function. Consequently, physicians use different techniques in the clinic. This study describes the evaluation of touch after median nerve lesions in the forearm and repair. In order to evaluate touch, 25 patients, aged 11-51 years (mean, 29 ye...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.10087
更新日期:2003-01-01 00:00:00
abstract::In order to create a model for epiphyseal growth plate transplantation by microvascular technique, a well-defined donor site was established. Dissection of latex-injected adult and juvenile dogs established the vascular supply to the proximal canine fibula. By isolating 7 cm of proximal fibula on the popliteal vessels...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920050210
更新日期:1984-01-01 00:00:00
abstract::This study demonstrates that intravenous epinephrine causes arterial vasospasm, but not venous constriction, in the microcirculation of the rat cremaster muscle. This effect can be blocked by a smooth muscle relaxant such as papaverine or an alpha receptor antagonist such as phentolamine. Circulating vasospastic agent...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920120111
更新日期:1991-01-01 00:00:00
abstract::Between 1987-2002, omental free-tissue transfer was used in 11 patients, aged 6-65 years (mean age, 37.6). The omentum was used for the treatment of brachial plexus injury pain (3 cases), Romberg's disease (1 case), defects of the extremities occurring with chronic obstructive arterial disease (2 cases), posttraumatic...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.10130
更新日期:2003-01-01 00:00:00
abstract:INTRODUCTION:Reconstruction of the lower leg commonly requires a free tissue transfer after Gustillo grade IIIB-IIIC injuries and severe postoncological resections, where, free musculocutaneous flaps (MCF) are preferred for their size and robust blood supply. The anastomoses are performed at more proximal levels to kee...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.20755
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:We conducted a clinical study to evaluate the effects of neurotization, especially comparing the total contralateral C7 (CC7) root transfer to hemi-CC7 transfer, on total root avulsion brachial plexus injuries (BPI). METHODS:Forty patients who received neurotization for BPI were enrolled in this prospective st...
journal_title:Microsurgery
pub_type: 杂志文章,随机对照试验
doi:10.1002/micr.22148
更新日期:2014-02-01 00:00:00
abstract::Soft tissue defects of the distal lower extremities are challenging. The purpose of this paper is to present our experiences with the free peroneal artery perforator flap for the reconstruction of soft tissue defects of the distal lower extremity. Nine free peroneal artery perforator flaps were used to reconstruct sof...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.22290
更新日期:2014-11-01 00:00:00
abstract::Extensive wounds about the knee can rarely be covered with local or even regional flaps. Free flaps often then become obligatory. Many factors will determine the surgeon's selection of the best donor site. Yet the patients' concerns with donor site morbidity cannot be overlooked. Most would agree that a large, but rel...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.22144
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Wound dehiscence, infection, and necrosis of tendon and overlying skin are severe complications after open repairs of Achilles tendon. A simultaneous reconstruction should be provided in a single stage operation. We evaluated the outcomes of one of the possible options: the radial forearm free flap with Flex...
journal_title:Microsurgery
pub_type: 临床试验,杂志文章
doi:10.1002/micr.22481
更新日期:2015-11-01 00:00:00
abstract::This is an experimental study comparing the suturing time and patency rate of a spiral interrupted suturing technique to those of conventional interrupted and continuous suturing technique in end-to-end as well as end-to-side anastomosis. The spiral interrupted suturing technique requires less time for either end-to-e...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920070205
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:To report the wide clinical experience and the research studies in the microsurgical treatment of peripheral lymphedema. METHODS:More than 1800 patients with peripheral lymphedema have been treated with microsurgical techniques. Derivative lymphatic microvascular procedures recognize today its most exemplar...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.20737
更新日期:2010-05-01 00:00:00
abstract::We have previously shown that the epigastric flap in Dark Agouty rats, measuring approximately 6 x 4 cm with borders related to well-defined anatomical structures, does not exhibit an all-or-none survival pattern. This study was designed to investigate the survival pattern of non-revascularized epigastric flaps in thr...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920140907
更新日期:1993-01-01 00:00:00
abstract::Cerebral aspergillosis infection is a rare disease in children that carries extremely high morbidity and mortality. Although occurring most commonly in the immunosuppressed patient, cerebral aspergillosis infection has been reported after trauma or neurosurgical procedures. Amphotericin B is the main medical therapy f...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.10154
更新日期:2003-01-01 00:00:00
abstract::The present study tests the hypothesis that peripheral hemodynamics in the rat femoral artery remain relatively stable during 3 hours of general anesthesia. Hemodynamic variables (pulse period, maximal centerline velocity, lumen diameter, and mean volumetric flow) were measured by the 20 MHz-pulsed ultrasonic Doppler ...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920070410
更新日期:1986-01-01 00:00:00