Reduction of reperfusion injury edema with corticotropin-releasing factor (CRF): a pilot study.

Abstract:

:Regulation of capillary permeability with ischemic reperfusion injury is a complex interaction between vascular endothelium and circulating blood factors. Corticotropin-releasing factor (CRF), a 41 -amino acid peptide CNS neurotransmitter known to modulate the pituitary-adrenal axis during stress response, has been shown to affect capillary leakage after thermal injury in peripheral tissue. When administered prior to ischemic reperfusion injury in a pedicled rat hindlimb model, CRF (80 mcg/kg) reduced limb weight gain to approximately 50% of saline control, suggesting a role for CRF in control of vascular permeability. The characteristics of CRF are reviewed.

journal_name

Microsurgery

journal_title

Microsurgery

authors

Whitney TM,Bentz ML,Johnson PC

doi

10.1002/(sici)1098-2752(1998)18:2<76::aid-micr3>3.

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

76-8

issue

2

eissn

0738-1085

issn

1098-2752

pii

10.1002/(SICI)1098-2752(1998)18:2<76::AID-MICR3>3.

journal_volume

18

pub_type

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