Abstract:
:Regulation of capillary permeability with ischemic reperfusion injury is a complex interaction between vascular endothelium and circulating blood factors. Corticotropin-releasing factor (CRF), a 41 -amino acid peptide CNS neurotransmitter known to modulate the pituitary-adrenal axis during stress response, has been shown to affect capillary leakage after thermal injury in peripheral tissue. When administered prior to ischemic reperfusion injury in a pedicled rat hindlimb model, CRF (80 mcg/kg) reduced limb weight gain to approximately 50% of saline control, suggesting a role for CRF in control of vascular permeability. The characteristics of CRF are reviewed.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Whitney TM,Bentz ML,Johnson PCdoi
10.1002/(sici)1098-2752(1998)18:2<76::aid-micr3>3.subject
Has Abstractpub_date
1998-01-01 00:00:00pages
76-8issue
2eissn
0738-1085issn
1098-2752pii
10.1002/(SICI)1098-2752(1998)18:2<76::AID-MICR3>3.journal_volume
18pub_type
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