Abstract:
BACKGROUND:Hepatitis C virus (HCV) is a leading cause of chronic liver disease (CLD) that can progress to cirrhosis and hepatocellular carcinoma. Genotypes of HCV can vary in pathogenicity and can impact on treatment outcome. OBJECTIVES:To study the different genotypes among patients with HCV related CLD attending a tertiary care hospital in south India during 2002-2012. STUDY DESIGN:Study subjects were those referred to clinical virology from the liver clinic. Genotyping was performed using the genotype specific core primers in nested polymerase chain reaction (PCR), 5' non-coding regions based PCR- restriction fragment length polymorphism and NS5B sequencing methods. With the latter method, obtained sequences were compared with published GenBank sequences to determine the genotype. RESULTS:Of the 451 samples tested, HCV genotype 3 was found to be the most predominant (63.85%). Other genotypes detected were genotype 1 (25.72%), genotype 2 (0.002%), genotype 4 (7.5%) and genotype 6 (2.7%). Genotype 3 was the common genotype in patients from Eastern India while genotype 1 and 4 were mainly seen in South Indian patients. Genotype 6 was seen exclusively in patients from North-Eastern India. Two other patients were infected with recombinants of genotype 1 and 2. CONCLUSIONS:In this study spanning a decade, HCV genotype 3 and genotype 1 were found to be the predominant genotypes in the Indian sub-continent. Genotype 4 and genotype 6 appeared to show some geographic restriction. A continued monitoring of HCV genotypes is essential for the optimum management of these chronically infected patients. In addition, knowledge of circulating genotypes could impact on future vaccine formulations.
journal_name
Indian J Med Microbioljournal_title
Indian journal of medical microbiologyauthors
Christdas J,Sivakumar J,David J,Daniel HD,Raghuraman S,Abraham Pdoi
10.4103/0255-0857.118875subject
Has Abstractpub_date
2013-10-01 00:00:00pages
349-53issue
4eissn
0255-0857issn
1998-3646pii
IndianJMedMicrobiol_2013_31_4_349_118875journal_volume
31pub_type
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