Abstract:
PURPOSE:Humans are the only known natural hosts of hepatitis C virus (HCV). This study was undertaken to examine the frequencies of human leucocyte antigens (HLAs) Class I and Class II genotype profiles in anti-HCV-infected patients of Northern India. MATERIALS AND METHODS:From a period of January 2013 to August 2014, 148 anti-HCV-positive patients of North India referred to the Department of Molecular Biology and Transplant Immunology, Indraprastha Apollo Hospitals, New Delhi, for performing HLA typing were included in the study. RESULTS:AFNx0102, AFNx0131 allele frequency decreased significantly in anti-HCV-positive patients. Frequencies for HLA-B loci did not reach any statistical significance. Among the Class II alleles, HLA-DRB1FNx0103 and HLA-DRB1FNx0110 were significantly higher in the patient population, and HLA-DRB1FNx0115 was significantly decreased in the patient population as compared to the controls. CONCLUSION:HLA-AFNx0133 was significantly increased as compared to control population and showed geographic variation in HCV-infected individuals of India.
journal_name
Indian J Med Microbioljournal_title
Indian journal of medical microbiologyauthors
Chowdhry M,Makroo RN,Singh M,Agrawal S,Kumar M,Thakur Ydoi
10.4103/0255-0857.188317subject
Has Abstractpub_date
2016-07-01 00:00:00pages
299-302issue
3eissn
0255-0857issn
1998-3646pii
IndianJMedMicrobiol_2016_34_3_299_188317journal_volume
34pub_type
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