Abstract:
OBJECTIVES:Human papillomavirus (HPV) infections are common in adolescent women, while the rare cancerous sequelae of HPV infections do not generally occur until the 4th or 5th decades of life. This prospective study of a cohort of adolescent women was performed to further our knowledge of the natural history of incident and prevalent HPV infections. METHODS:Self-vaginal swabs collected from high-risk, unvaccinated adolescent women in a longitudinal study were analysed for HPV DNA. Sera were collected at enrolment and later tested for HPV antibodies. Statistical analysis was performed to determine the HPV genotype distribution and duration of detection, and to determine rates of seropositivity and seroconversion for HPV types represented in the assays. RESULTS:146 subjects (mean enrolment age=15.4 years; mean duration of follow-up=5.8 years) had samples adequate for analysis of HPV detection, and 95 of these subjects had paired sera available. The cumulative prevalence for high-risk and low-risk HPV types was 95.9% and 91.1%, respectively. HPV types 6, 11, 16 and 18 (HPV types represented in the quadrivalent vaccine) were found at some point in 40.4%, 6.2%, 48% and 24% of participants, respectively. Serological data confirmed exposure to these vaccine-covered types, as well as to other high-risk HPV types. CONCLUSIONS:In this cohort of adolescent women, high- and low-risk HPV types were frequently detected, and serological data confirmed exposure in most subjects. The high-prevalence HPV types represented in the quadrivalent HPV vaccine further support vaccination of women at an age well before sexual debut.
journal_name
Sex Transm Infectjournal_title
Sexually transmitted infectionsauthors
Ermel AC,Shew ML,Weaver BA,Qadadri B,Denski C,Tu W,Tong Y,Fortenberry JD,Brown DRdoi
10.1136/sextrans-2012-050886subject
Has Abstractpub_date
2014-02-01 00:00:00pages
64-9issue
1eissn
1368-4973issn
1472-3263pii
sextrans-2012-050886journal_volume
90pub_type
杂志文章abstract:OBJECTIVES:Oropharyngeal squamous cell carcinoma is the most common human papillomavirus (HPV)-associated cancer in the UK, but little is known about the prevalence of oropharyngeal HPV in sexually active teenagers. We investigated reported HPV vaccination coverage (in females) and prevalence of oropharyngeal HPV in se...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2020-054428
更新日期:2020-09-03 00:00:00
abstract:OBJECTIVE:To determine the seroprevalence rate of syphilis among pregnant women attending the antenatal clinics of a teaching and a state specialist hospital in Nigeria, in order to ascertain whether maternal screening should be incorporated into routine antenatal care of our hospitals. METHODS:A screening for syphili...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2006.023416
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVES:To examine herpes simplex virus type 2 (HSV-2) incidence over four periods to age 38 in a birth cohort, and to compare risks for men and women, taking into account sexual behaviour. METHODS:At ages 21, 26, 32 and 38, participants in the Dunedin Multidisciplinary Health and Development Study were invited to ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2013-051235
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:To design and implement an HIV surveillance system using periodic cross sectional prevalence surveys in National Guard recruits of the Republic of Cyprus. METHODS:HIV infection surveillance used unlinked anonymous screening (UAS) methodology, which tested residual blood originally collected for other purpos...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.78.1.50
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVES:Trichomoniasis (TV) is associated with an increased risk of acquisition of sexually transmitted diseases (STDs) and HIV. The purpose of this study is to evaluate factors associated with incidence TV among female STD clinic attendees in the USA. METHODS:Data were collected from women participating in a rando...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/sextrans-2015-052010
更新日期:2016-02-01 00:00:00
abstract::The potential for exposure of low and high risk women to HIV and sexually transmitted infections (STI) through unprotected sex with male clients of female sex workers in Cotonou could account for most if not all of the estimated yearly numbers of HIV infections in Cotonou women (approximately 1000). As ongoing transmi...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.78.suppl_1.i69
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVES:Biologically false positive (BFP) reactions are well described in early literature. However, only a few recent reports described the incidence and clinical characteristics of patients with BFP reactions. We reviewed the serological test results of patients tested for syphilis in our hospital in the past deca...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2020-054628
更新日期:2020-11-18 00:00:00
abstract:OBJECTIVE:To estimate the cumulative incidence of severe complications associated with genital chlamydia infection in the general female population. METHODS:The Uppsala Women's Cohort Study was a retrospective population based cohort study in Sweden, linking laboratory, hospital, and population registers. We estimated...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2005.017186
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:In countries where STI/HIV prevalence data and behavioural data are scarce UNAIDS second generation HIV surveillance guidelines recommend measuring STI/HIV prevalence and risk behaviours in vulnerable populations but do not recommend conducting these surveys concurrently because of concerns about participati...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.78.3.187
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVES:A new molecular test for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) (GeneXpert CT/NG) has been demonstrated to be as accurate as conventional nucleic acid amplification tests (NAAT), but performance has not been evaluated in routine primary care, performed at the point of care by clinicians. W...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,随机对照试验
doi:10.1136/sextrans-2017-053443
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:To assess the validity of sexual behaviour data collected from African adolescents using five methods. METHODS:9280 Tanzanian adolescents participated in a biological marker and face to face questionnaire survey and 6079 in an assisted self-completion questionnaire survey; 74 participated in in-depth intervi...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2004.011924
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVES:To review the uptake of a new service for condom provision in the under 16s. METHODS:A retrospective case note review of attenders at an inner London sexual health clinic. RESULTS:The service was audited over a 3 month period in the spring of 2000. There were 97 individual attendances, 94% (92) male and 6%...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.77.4.287
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVES:Geosocial networking application specific to men who have sex with men (MSM) (gay app) has revolutionised the social networking of MSM globally, much concern was raised over its linkage to HIV/syphilis risk. This study sought to examine the association between use of gay app and sexual behaviours and HIV/syp...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2018-053902
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:To assess changes in seroadaptive behaviours among men who have sex with men (MSM) in San Francisco over the past 4 years. METHODS:461 MSM were recruited in 2008 as the second wave of the US National HIV Behavioural Surveillance (NHBS) survey in San Francisco. Participants were classified into patterns of s...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2010.042986
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:Bacterial vaginosis (BV) is characterised by a change in the microbial composition of the vagina. The BV-associated organisms outnumber the health-associated Lactobacillus species and form a polymicrobial biofilm on the vaginal epithelium, possibly explaining the difficulties with antibiotic treatment. A bet...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2015-052475
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:A growing body of evidence is increasingly demonstrating the effectiveness of condoms for sexually transmitted infection (STI) prevention. The purpose of the present analysis was to provide a disease specific estimate for the effectiveness of condoms in preventing Chlamydia trachomatis infection w...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2004.012799
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVES:Treatment of Neisseria gonorrhoeae is threatened by the emergence of antimicrobial resistance. We analysed data from the Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) in England and Wales to identify groups most at risk of reduced susceptibility to the currently recommended first-lin...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2016-052583
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of Mycoplasma genitalium on the outcome of pregnancy. METHODS:Cervical samples from women who had previously participated in a case-control study (designed to assess the impact of syphilis and HIV-2 on the outcome of pregnancy in Guinea-Bissau) were processed using a PCR assay to detec...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.78.4.289
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVES:To study the tolerance and acceptability in Africa of a perinatal intervention to prevent vertical HIV transmission using benzalkonium chloride disinfection. DESIGN:A randomized, double blinded phase II trial. SETTING:Prenatal care units in Abidjan (Côte d'Ivoire) and Bobo-Dioulasso (Burkina Faso). PATIEN...
journal_title:Sexually transmitted infections
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/sti.75.6.420
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:To examine the views of educated people in Togo on the acceptability of criminal prosecution of a male partner for sexual transmission of infectious diseases (STIDs) to his female partner. METHODS:199 adults living in Kara, Togo judged acceptability of criminal prosecution for STID in 45 scenarios composed o...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2012-050964
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Human trichomoniasis is the most common non-viral sexually transmitted disease, yet immune responses are not well studied. METHODS:Since the Trichomonas vaginalis lipophosphoglycan (TvLPG) is an important virulence factor, a bank of eight monoclonal antibodies was generated to define the antigen in clinical...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2012-051013
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To assess STD management in primary healthcare facilities where STD clinics and syndromic management guidelines had been introduced. METHODS:In 26 health facilities in selected sites, we observed management of all STD patients presenting in the adult general or STD clinic. We assessed the referral system by ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.78.1.e2
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVES:To compare two methods for sampling female sex workers (FSWs) for bio-behavioural surveillance. We compared the populations of sex workers recruited by the venue-based Priorities for Local AIDS Control Efforts (PLACE) method and a concurrently implemented network-based sampling method, respondent-driven samp...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2012-050638
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:To analyse changes in testing for sexually transmissible infections (STI) among gay and bisexual men in Melbourne, Sydney and Queensland, Australia, particularly comprehensive STI testing (at least four tests from different anatomical sites in the previous year), and the characteristics of men who had such t...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sextrans-2013-051294
更新日期:2014-05-01 00:00:00
abstract::Recent advances in genetic characterisation of Trichomonas vaginalis isolates show that the extensive clinical variability in trichomoniasis and its disease sequelae are matched by significant genetic diversity in the organism itself, suggesting a connection between the genetic identity of isolates and their clinical ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sextrans-2013-051098
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To construct confidence intervals for HIV prevalence in countries with generalised epidemics. METHODS:In the Bayesian melding approach, a sample of country-specific epidemic curves describing HIV prevalence over time is derived based on time series of antenatal clinic prevalence data and general information ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2008.029991
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVES:As the global HIV pandemic enters its fourth decade, countries have collected longer time series of surveillance data, and the AIDS-specific mortality has been substantially reduced by the increasing availability of antiretroviral treatment. A refined model with a greater flexibility to fit longer time serie...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2012-050689
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Identifying predictors that contribute to geographical disparities in sexually transmitted infections (STIs) is necessary. This study assesses the spatial relationship between condom availability to locations of STIs in order to better understand these geographical disparities. OBJECTIVES:We conducted a con...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2015-052144
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVES:To develop, evaluate and implement a new multiplex real-time PCR test for the detection of herpes simplex virus (HSV)1, HSV2 and syphilis in a single sample using a single test. METHODS:A multiplex real-time PCR test detecting HSV1, HSV2 and Treponema pallidum was designed, validated and evaluated for a per...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2009.040451
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVES:Transgender men who have sex with men (TMSM) represent an understudied population in relation to screening for HIV and sexually transmitted infections (STIs). We examined HIV and STI testing prevalence among TMSM along with the factors associated with testing in a diverse US nationwide sample of TMSM. METHO...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2020-054474
更新日期:2020-09-01 00:00:00