Abstract:
OBJECTIVES:To examine herpes simplex virus type 2 (HSV-2) incidence over four periods to age 38 in a birth cohort, and to compare risks for men and women, taking into account sexual behaviour. METHODS:At ages 21, 26, 32 and 38, participants in the Dunedin Multidisciplinary Health and Development Study were invited to provide serum for HSV-2 serology, and information on sexual behaviour. HSV-2 incidence rates were calculated for four age periods, and comparisons made by sex and period, taking into account number of sexual partners. RESULTS:By age 38, 17.3% of men and 26.8% of women had ever been seropositive for HSV-2. Incidence peaked for women from age 21 to 26 (19.1 per 1000 person-years) and men from age 26 to 32 (14.1 per 1000 person-years); it fell markedly for both from age 32 to 38 (5.1 and 6.8 per 1000 person-years for men and women, respectively). Overall risk was significantly higher for women: adjusted incidence rate ratio 1.9 (95% CI 1.4 to 2.7); the sex difference was most marked from age 21 to 26 (3.4, 95% CI 1.9 to 6.3). CONCLUSIONS:Our findings are consistent with a greater biological susceptibility to HSV-2 among women, and with the increasing risk to the early/mid-20s for women and late 20s/early 30s for men, being driven by an increasing pool of prevalent infection. The reduced risk in the mid-30s is consistent with declining infectivity of long-term prevalent infections.
journal_name
Sex Transm Infectjournal_title
Sexually transmitted infectionsauthors
Dickson N,Righarts A,van Roode T,Paul C,Taylor J,Cunningham ALdoi
10.1136/sextrans-2013-051235subject
Has Abstractpub_date
2014-05-01 00:00:00pages
243-5issue
3eissn
1368-4973issn
1472-3263pii
sextrans-2013-051235journal_volume
90pub_type
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
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更新日期:2009-08-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
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更新日期:2013-09-01 00:00:00
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doi:10.1136/sextrans-2012-050886
更新日期:2014-02-01 00:00:00
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更新日期:2020-02-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2002-12-01 00:00:00
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更新日期:2016-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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更新日期:2002-12-01 00:00:00
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更新日期:2002-06-01 00:00:00
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更新日期:2001-02-01 00:00:00
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更新日期:2015-09-01 00:00:00
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更新日期:2016-11-01 00:00:00
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更新日期:2013-09-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2014-051751
更新日期:2015-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1998-06-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
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更新日期:2006-08-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2010.042333
更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-04-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
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更新日期:2009-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/sextrans-2015-052088
更新日期:2016-03-01 00:00:00