[Proliferating cell nuclear antigen in cervical cancer and precursor lesions].

Abstract:

:The aim of this study was to study the degree of cellular proliferation quantifying the immunohistochemical expression of the proliferating cell nuclear antigen. We assessed paraffin embedded samples of 25 infiltrating epidermoid cervical carcinomas, 76 precursor lesions (34 of low and 42 of high grade), 29 normal and 13 metaplastic epidermoid epithelia. Mean values of proliferating cell nuclear antigen expression were 13.7% in normal epithelia, 15.7% in epidermoid metaplasia, 37.1% in low grade precursor lesions (35.3% in condilomas and 38.8% in mild dysplasia), 48.7% in high grade lesions (47.9% in moderate dysplasias, 50.5% in severe dysplasias and 50% in carcinoma in situ) and 54.7% in infiltrating carcinoma. There were differences in proliferating cell nuclear antigen expression nd mitotic index between low grade precursor lesions and high grade lesions and infiltrating carcinoma. No correlation was observed between mitotic index and proliferating cell nuclear antigen expression. We conclude that infiltrating epidermoid cervical carcinoma and its precursor lesions have a high level of proliferative activity, demonstrated by a high percentage of cells in active phases of the cellular cycle.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Wistuba I,Roa I,Araya JC,Villaseca M,Capurro I,Chávez F

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

1077-83

issue

9

eissn

0034-9887

issn

0717-6163

journal_volume

123

pub_type

杂志文章
  • [Tuberculosis and diabetes mellitus: a longitudinal-retrospective study in a teaching hospital].

    abstract::We analyzed 1529 diabetic patients seen between 1959 and 1982 at a teaching hospital in Concepción, Chile. 116 of them were insulin dependent diabetics. Gestational diabetes was excluded. The 10 year actuarial risk of acquiring tuberculosis was 24.2% for insulin-dependent diabetics and 4.8% for the rest (p less than 0...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Olmos P,Donoso J,Rojas N,Landeros P,Schurmann R,Retamal G,Meza M,Martinez C

    更新日期:1989-09-01 00:00:00

  • [Immunogenicity and reactogenicity of a reduced antigen content diphtheria, tetanus and acellular pertussis vaccine dTpa) in 10 to 11 years old children and in adults].

    abstract:BACKGROUND:New vaccination strategies are needed to control the increasing problem of pertussis in teenagers and adults. AIM:To determine the immunogenicity and reactogenicity of a diphtheria-tetanus-acellular pertussis (dTpa) vaccine with reduced antigen content. MATERIAL AND METHODS:A single dose of the dTpa vaccin...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Abarca K,Valdivieso F,Potin M,Ibáñez I,Vial P

    更新日期:2002-05-01 00:00:00

  • [Association between handgrip strength and functional performance in Chilean older people].

    abstract:BACKGROUND:Handgrip strength is an important predictor of functional performance among older adults. AIM:To measure handgrip strength in older adults and relate its values to their clinical functional assessment. MATERIAL AND METHODS:Handgrip strength was measured in 1047 older adults living in the community and aged...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872016000500007

    authors: Mancilla S E,Ramos F S,Morales B P

    更新日期:2016-05-01 00:00:00

  • [Enteral nutrition in severe ulcerative colitis. Digestive tolerance and nutritional efficiency].

    abstract:BACKGROUNDS AND AIMS:Total parenteral nutrition (TPN) has been traditionally used as an adjunctive therapy in severe ulcerative colitis patients. We performed a prospective study to ascertain the safety, nutritional efficiency, tolerance and costs of total enteral nutrition in this situation. METHODS:After 48 hours of...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Klaassen J,Zapata R,Mella JG,Aguayo G,Alvarado D,Espinosa O,Maíz A,Zúñiga A,Quintana C

    更新日期:1998-08-01 00:00:00

  • [Effect of VKORC1 and CYP2C9 variants on dosage of oral anticoagulants in Chilean individuals].

    abstract:BACKGROUND:The dose of oral anticoagulants (OAC) shows great variability among patients. Pharmacogenetic studies have shown that common variants in genes CYP2C9 (*2 and *3) and VKORC1 (-1639G>A) are associated with lower requirements of OAC. AIM:To study the association between average maintenance doses of oral antico...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872015001100001

    authors: Benavides F,Grossman N,Poggi H,Nieto E,Bertrán A,Araos D,Vásquez M,Ibarra I,Cáceres F,Espinoza K,Lagos M,Repetto M G

    更新日期:2015-11-01 00:00:00

  • [Herpes simplex virus type 1 as risk factor associated to Alzheimer disease].

    abstract::Herpes simplex virus type 1 (HSV-1) is ubiquitous, neurotropic, and the most common pathogenic cause of sporadic acute encephalitis in humans. Herpes simplex encephalitis is associated with a high mortality rate and significant neurological, neuropsychological, and neurobehavioral sequels. HSV-1 infects limbic system ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:/S0034-98872011000600013

    authors: Martin C,Solís L,Concha MI,Otth C

    更新日期:2011-06-01 00:00:00

  • [Cephalosporins: bacterial resistance measured by penicillin-binding proteins].

    abstract::Antibacterial potency of cephalosporins depends on inhibition (acylation) of one or more penicillin-binding proteins (PBP). Recently, reduced affinity of PBP for cephalosporins and other B-lactam agents has been found in some cases. Mechanism for these changes in affinity are analyzed in this review. ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:

    authors: Garrido J,López F

    更新日期:1989-09-01 00:00:00

  • [Legal recognition of transsexuality in Chile through the judicial procedure for name change].

    abstract::Do transsexual people in Chile have a right to have their gender identity or their sex reassignment legally recognized? The absence of any legislation on gender identity or transsexualism could lead us to believe that it is not the case. However, a quantitative review of decisions issued by Chilean courts during the l...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872015000800008

    authors: Muñoz León F

    更新日期:2015-08-01 00:00:00

  • [Ectopic or migrating spleen and supernumerary spleens: detection and identification with 99mTc, 51Cr and 113In radioisotopes].

    abstract::Congenital malformations of the spleen are rare. We report a patient with an ectopic spleen located in the left iliac fossa, which was excised in order to prevent severe complications such as torsion of the pedicle, rupture or infection. A second patient with idiopathic thrombocytopenic purpura presented with an acces...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:

    authors: Etcheverry R,Allamand JP,Guzmán G,Robinson MI

    更新日期:1989-12-01 00:00:00

  • [Immunophenotype. Clinical and laboratory features of acute lymphoblastic leukemia in Chile. Study of 500 children and 131 adults].

    abstract::We describe the clinical features and immunophenotype of 500 children and 131 adults with acute lymphoblastic leukemia (ALL), diagnosed between 1984 and 1993. Cases were classified, according to immunophenotype in B-cell ALL with three subtypes (pro-B or null, common and B) and T-cell ALL. Among children, common ALL a...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Cabrera ME,Labra S,Ugarte S,Matutes E,Greaves MF

    更新日期:1996-03-01 00:00:00

  • [Adult cyclic neutropenia: acute ileitis as an initial clinical manifestation].

    abstract::Cyclic neutropenia is a rare disease in which blood neutrophils periodically decrease and almost disappear, ensuing acute infections of variable severity. We report a 37 years old female presenting with severe abdominal pain, fever and neutropenia. During a surgical abdominal exploration, an acute ileitis was found. D...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Larraín C,Gómez J

    更新日期:1995-06-01 00:00:00

  • ["Revista Médica de Chile": 120 years (July 1872-July 1992)].

    abstract::The "Revista Medica de Chile" founded in 1872 is the second oldest medical journal in Latin America after the "Gaceta Medica de Mexico" (1864). Among medical journals in the world it is placed 24. It has been published monthly without interruption, except for the period January through December 1891, due to the revolu...

    journal_title:Revista medica de Chile

    pub_type: 历史文章,杂志文章

    doi:

    authors: Costa-Casaretto C

    更新日期:1992-07-01 00:00:00

  • [Small intestine bacterial overgrowth in patients with chronic pancreatitis].

    abstract:BACKGROUND:Previous reports describe 30-40% of small intestine bacterial overgrowth (SIBO) in patients with chronic pancreatitis (CP), SIBO is a cause of persistent symptoms in this group of patients even when they are treated with pancreatic enzymes. AIM:To asses the frequency of SIBO in patients with CP. PATIENTS A...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872008000800003

    authors: Mancilla A C,Madrid S AM,Hurtado H C,Orellana B C,Peña Z M,Tobar A E,Berger F Z

    更新日期:2008-08-01 00:00:00

  • [Hemoglobin, serum iron and transferrin saturation among users of intrauterine devices and oral contraceptive agents].

    abstract::We studied 60 females using either intrauterine device or taking oral contraceptive pills. Hemoglobin, serum iron, total iron binding capacity and saturation of transferrin were determined before and 4 and 10 months after starting a responsible paternity program. Women with a basal hemoglobin level below 12 g/dl were ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Palomo I,Grebe G,Valladares G,Bustos P,Ferrada M

    更新日期:1990-05-01 00:00:00

  • [Hernán Iturriaga Ruiz, M.D., President of the Medical Society of Santiago, 1995-1997].

    abstract::Dr. Hernán Iturriaga is now President of Sociedad Médica de Santiago (Chilean Society of Internal Medicine) for the period 1995-1997. He received his M.D. title at the University of Chile in 1961 and his postgraduate training included a USPHS International Postdoctoral Research Fellowship at Mount Sinai School of Medi...

    journal_title:Revista medica de Chile

    pub_type: 传,历史文章,杂志文章

    doi:

    authors:

    更新日期:1996-07-01 00:00:00

  • [Skin prick test of immediate hypersensitivity in a selected Chilean pediatric population sample].

    abstract:BACKGROUND:Skin prick test (SPT) of immediate hypersensitivity is a main instrument in the diagnosis of allergy. AIM:To demonstrate the applicability of skin prick test in different age groups. PATIENTS AND METHODS:We studied children and adolescents with the diagnosis of allergy in the Pediatric Respiratory Laborato...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872005000200007

    authors: Martínez J,Méndez C,Talesnik E,Campos E,Viviani P,Sánchez I

    更新日期:2005-02-01 00:00:00

  • [Recent alcohol and drug consumption in victims of work related accidents].

    abstract:BACKGROUND:Twenty to twenty two percent of work related accidents have a direct or indirect relationship with recent alcohol use. AIM:To detect recent alcohol or drug use in patients who required hospitalization for severe work related accidents. PATIENTS AND METHODS:Blood and urine samples were obtained from patient...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Trucco M,Rebolledo P,González X,Correa A,Bustamante M

    更新日期:1998-10-01 00:00:00

  • [Renal oncocytoma: 4 cases].

    abstract::Oncocytomas are tumors characterized by cells with an eosinophilic cytoplasm. Renal oncocytomas were described in 1942. Among 46 consecutive patients operated on for renal tumors, oncocytomas were found in 4 (8.7%). In spite of a supposedly benign nature, renal oncocytoma cannot be adequately differentiated from renal...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Castillo O,van Cauwelaert R,Aguirre C,Arellano L,Medina FJ

    更新日期:1992-05-01 00:00:00

  • [Acute promyelocytic leukemia: results of the Chilean protocol LPA2000].

    abstract:BACKGROUND:The current recommendations for treatment of patients with newly diagnosed acute promyelocytic leukemia (APL) include all-trans-retinoic acid (ATRA) and anthracycline based chemotherapy. AIM:To evaluate the results of the Chilean protocol following the LPA99 regimen of the Spanish PETHEMA group, except for ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872013001000001

    authors: Undurraga MS,Puga B,Cabrera ME,Palma T,Rossle A,Vergara CG,Rojas B,Aspillaga A

    更新日期:2013-10-01 00:00:00

  • [A personal view of endocrinology in Chile].

    abstract::In a short historical review of the outstanding changes occurred in the whole of endocrinology and particularly in Chile over the last 60 years -with the background of an infant mortality drop from 200 per thousand in 1940 to 8 per thousand today and a mean life expectancy increase from 42 to 76 years- the author outl...

    journal_title:Revista medica de Chile

    pub_type: 历史文章,杂志文章

    doi:10.4067/s0034-98872005000600017

    authors: Jadresic A

    更新日期:2005-06-01 00:00:00

  • [Medical care in Santiago, 1993].

    abstract::Results of morbidity and medical care surveys performed in Santiago in 1993-94 are presented in this paper. The study has been done in an aleatory population sample of 4,700 people coming from 1,000 dwellings. Main results are as following: The Health National Fund (FONASA) is the most important financing medical care...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Medina E,Kaempffer AM,Cornejo E,Hernández E,Wall V

    更新日期:1995-01-01 00:00:00

  • [Synchronous tumors detected with contrast-enhanced F18-FDG positron emission tomography/computed tomography (PET/CTc) in colorectal cancer].

    abstract:BACKGROUND:Colorectal cancer (CRC) is the third most prevalent cancer in the world and is the second cause of cancer death. Positron emission tomography/computed tomography (PET/CT) using 18F-FDG is used for its staging and follow up. AIM:To assess the occurrence of synchronous colonic and extracolonic tumors detected...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872019000700828

    authors: Ladrón-de-Guevara D,Pérez D,Núñez P,Ramírez F,Zárate A,López F

    更新日期:2019-07-01 00:00:00

  • [Cross cultural psychometric comparison of major depression in Chile and Germany].

    abstract:BACKGROUND:Depressive symptoms and personality features of patients with mood disorders are supposed to have a strong variability in cross cultural studies. The clinical profile, the outcome and the treatment response seem to be different across the world. AIM:To investigate the differences and similarities of major d...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Heerlein A,Gabler G,Chaparro C,Kraus A,Richter P,Berkau C

    更新日期:2000-06-01 00:00:00

  • [SPECT tomography with F 18-fluorodeoxyglucose in a recent myocardial infarction clinical case].

    abstract::We report a 50-year-old woman with a recent myocardial infarction in whom a myocardial perfusion single photon emission computed tomography (SPECT) with Thallium201 was done simultaneously with a F18-fluorodeoxyglucose (FDG) SPECT to study glucose metabolism. Myocardial infarction was located in the anteroseptal and a...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: González P,Coll C,Massardo T,Sierralta P,Humeres P,Aramburú I,Brugère S,Yovanevich J,Ramírez A,Jofré J,Chamorro H,Kuntsmann S,López H

    更新日期:2000-09-01 00:00:00

  • [Cholangiocarcinoma].

    abstract::Cholangiocarcinoma is a malignant lesion of the bile duct epithelium. Its incidence and prevalence are low. It appears from the sixth decade of life and there is slight male predominance. It is most frequently found in the confluence of the hepatic ducts, where it is called hilar cholangiocarcinoma or Klatskin tumor. ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:/S0034-98872008000200015

    authors: Burgos San Juan L

    更新日期:2008-02-01 00:00:00

  • [Active and refractory ulcerative proctitis: an update].

    abstract::Ulcerative colitis (UC) is a chronic inflammatory disease of unknown etiology that affects a variable length of the colon, starting from the rectum. When the disease is confined to the rectum is called ulcerative proctitis (UP). Several studies have unsuccessfully attempted to determine the factors that determine the ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:/S0034-98872010000100016

    authors: Caselli M G,Pinedo M G,Zúñiga D A,Alvarez L M

    更新日期:2010-01-01 00:00:00

  • [Nodular goiter recurrent after surgery. A study of its pathogenesis and incidence].

    abstract::We analyzed 33 patients with recurring nodular goiter (from a population of 2,500 operated patients). Recurrence occurred 0.7 to 12 years after surgery. T4, T3, TSH, perchlorate and TRH tests were performed in 18. Results were similar to those in 13 operated patients without recurrence. Administration of thyroid hormo...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Villaseca R,López Caffarena E

    更新日期:1990-01-01 00:00:00

  • [Digoxin is effective in th treatment of patients with heart failure and sinus rhythm].

    abstract::Due to differences in treatment effect in studies on the effectiveness of digoxin in patients with congestive heart failure in sinus rhythm, a cross-over placebo-controlled, randomized double blind clinical trial was performed. Thirty one patients, without previous treatment with digoxin, in New York Heart Association...

    journal_title:Revista medica de Chile

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Lanas F,Standen D,Steinmann WC,Montecinos A,Stockins B

    更新日期:1994-10-01 00:00:00

  • [Clinical picture at the onset of type 1 diabetes mellitus in children].

    abstract:BACKGROUND:Type 1 diabetes mellitus (DM1) is a disease of increasing incidence among children. The time elapsed between the beginning of symptoms and the diagnosis of the disease is, in most cases, very extended. AIM:To report the clinical picture at onset and laboratory features of children with DM1. MATERIAL AND ME...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872006001200007

    authors: Hodgson B MI,Ossa A JC,Velasco F N,Urrejola N P,Arteaga L I A

    更新日期:2006-12-01 00:00:00

  • [Mechanical ventilation to treat acute respiratory distress syndrome secondary to descending necrotizing mediastinitis. Role of dynamic axial computed tomography of the lung].

    abstract::Lung computed tomography (CT) is being used increasingly to assess lung morphology in patients on mechanical ventilation. Lung CT under known levels of airway pressure (dynamic CT) can also assess the response of lung parenchyma to ventilatory therapy. We report a patient with acute respiratory distress syndrome secon...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Bugedo G,Bruhn A,Hernández G,Rojas G,Aparicio R,Castillo L

    更新日期:2003-02-01 00:00:00