[Digoxin is effective in th treatment of patients with heart failure and sinus rhythm].


:Due to differences in treatment effect in studies on the effectiveness of digoxin in patients with congestive heart failure in sinus rhythm, a cross-over placebo-controlled, randomized double blind clinical trial was performed. Thirty one patients, without previous treatment with digoxin, in New York Heart Association (NYHA) functional class II to IV, with a dilated left ventricle and/or ventricular systolic dysfunction were included. Patients received digoxin, adjusted for blood levels, or placebo, during an 8 week period, prior to crossing over to the other treatment for another 8 weeks. The order of treatments was randomly allocated. Outcome measurement were performed at the end of each 8 week period. Digoxin, compared with placebo, improved NYHA class, 6.9% vs 41.4% (p = 0.013) and increased the treadmill exercise time, 406 +/- 204 s vs 484 +/- 185 s (p = 0.003). During the digoxin treatment the left ventricular and systolic diameter was reduced from 52.9 +/- 8.9 to 50.1 +/- 9.7 mm (p = 0.016) and the shortening fraction increased from 21.4 +/- 8.3 to 24.8 +/- 8.1% (p = 0.009). No significant difference was observed in the left ventricular end diastolic diameter (LVED) of the left ventricle and in a estimation of quality of life. In conclusion, digoxin treatment produced a significant improvement in functional capacity, exercise time, and left ventricular performance.


Rev Med Chil


Revista medica de Chile


Lanas F,Standen D,Steinmann WC,Montecinos A,Stockins B


Has Abstract


1994-10-01 00:00:00












  • [Carcinoma hepatocellular. Description of verified clinical characteristics in a region of Southern Chile].

    abstract:BACKGROUND:Hepatocellular carcinoma is the most frequent primary tumor of the liver. It is associated to chronic liver diseases and has a high prevalence in some regions of Africa and Asia. AIM:To describe the clinical characteristics of patients with hepatocellular carcinoma, admitted to two hospitals of the IX regio...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,多中心研究


    authors: Manterola C,Muñoz S,Araya JC,Calderón C,Barroso MS

    更新日期:2000-08-01 00:00:00

  • [Understanding cortisol action in acute inflammation: A view from the adrenal gland to the target cell].

    abstract::Glucocorticoids (cortisol in humans) are essential for numerous biological functions. Among critically ill patients, therapy with cortisol has gained strength in recent years, but clinical results have been mixed. A series of events, that may explain the diversity of clinical responses, occur from the synthesis of cor...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审


    authors: Guerrero J

    更新日期:2017-02-01 00:00:00

  • [Malignant neuroleptic syndrome, medical-psychiatric approach].

    abstract::We report the case of a 42 years old male, with a bipolar disorder and receiving lithium therapy, valproic acid and clonazepam. Due to an exacerbation of his underlying disease, he was admitted to a psychiatric clinic and received 50 mg of intramuscular chlorpromazine in two occasions. Afterwards, the patient had an a...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Giacamán P,Andresen M,Gareca N,Bitrán J,Dougnac A

    更新日期:1997-02-01 00:00:00

  • [Carcinoembryonic antigen (CEA) as an independent prognostic factor in colorectal carcinoma].

    abstract:BACKGROUND:CEA is widely used in the follow up of patients with colorectal carcinoma. AIM:To study the value of preoperative CEA as an independent prognostic factor in colorectal carcinoma. PATIENTS AND METHODS:Analysis of 373 operated patients (204 females, age range 21-92 years) with colorectal carcinoma and a mean...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Bannura G,Cumsille MA,Contreras J,Barrera A,Melo C,Soto D

    更新日期:2004-06-01 00:00:00

  • [Microalbuminuria and urinary albumin excretion in clinical practice].

    abstract::Microalbuminuria is a new tool in the management of patients with diabetes mellitus or hypertension. Microalbuminuria is an easily measured biomarker in a urine sample. Urinary albumin to creatinine ratio in first morning urine sample correlates with 24 hours urinary albumin excretion, but it is easier to obtain, and ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审


    authors: Tagle R,González F,Acevedo M

    更新日期:2012-06-01 00:00:00

  • [The need for nuclear medicine specialists and gamma cameras].

    abstract:BACKGROUND:The ideal number of nuclear medicine specialists in relation to the needs of a given population should be defined by the institutions training such specialists. AIM:To establish the relationship between the number of gammacameras, nuclear medicine specialists and the number of inhabitants in different count...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: González P,Muñoz A

    更新日期:1996-12-01 00:00:00

  • Type I persistent proatlantal artery associated with fusiform subclavian artery aneurysm: Report of one case.

    abstract::We report a 61 years old male presenting with a right cerebral infarction, along with a type I persistent left proatlantal artery (PA), which is a form of primitive carotid-basilar anastomosis. The patient had an absence of the ipsilateral vertebral artery (VA) and hypoplasia of the contralateral VA, while the basilar...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Buljan K,Hegeduš I,Gilman Kuric T,Salha T,Tomić S,Butković Soldo S,Buljan V,Šošić Đ

    更新日期:2015-08-01 00:00:00

  • [A historical view of cardiology in Chile 1930-1990].

    abstract::The most significant facts in the development of Chilean cardiology since 1930 are reviewed. The preeminence of great clinicians in the thirties was followed by the creation of Departments of Cardiology in University Hospitals. The emergence of powerful diagnostic tools and cardiac surgery allowed an accelerated devel...

    journal_title:Revista medica de Chile

    pub_type: 历史文章,杂志文章


    authors: Noguera H

    更新日期:1990-10-01 00:00:00

  • [Are congenital malformations increasing? Comparative study of 2 periods: 1971-1977 and 1982-1991, in the maternity of the Clinical Hospital of the University of Chile].

    abstract::The aim of this work was to analyze the global incidence of congenital malformations at the Maternity of University of Chile Clinical Hospital in the periods between 1971 and 1977 and between 1982 and 1992. A significant and sustained increase in incidence was observed in the first period from 10.64 per 1000 born aliv...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Nazer Herrera J,Cifuentes L,Ruiz G

    更新日期:1993-09-01 00:00:00

  • [Effects of glycine on auditory evoked potentials among diabetic patients with auditory pathway neuropathy].

    abstract:BACKGROUND:Glycine inhibits the formation of advanced glycation end products that may cause central and peripheral neuronal damage, affecting also the auditory nerve. AIM:To evaluate the effect of glycine on auditory nerve conduction and hearing level among patients with type 2 diabetes mellitus and auditory neuropath...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Muñoz-Carlin Mde L,Rodríguez-Moctezuma JR,Gómez Latorre JG,Montes-Castillo ML,Juárez-Adauta S

    更新日期:2010-10-01 00:00:00

  • [Endobronchial ultrasound and fine needle aspiration for central airway lesions].

    abstract:BACKGROUND:Endobronchial ultrasound-guided trans-bronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure with a high diagnostic yield for lesions adjacent to the central airway. AIM:To describe the diagnostic yield of EBUS-TBNA for lesions suspicious of Non-Small Cell Lung Cancer (NSCLC). MATERIAL A...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Fernández-Bussy S,Labarca G,Caviedes I,Folch E,Majid A

    更新日期:2016-03-01 00:00:00

  • [Subacute combined degeneration of the spinal cord caused by vitamin B12 deficiency. Report of 11 cases].

    abstract:BACKGROUND:Subacute combined degeneration is a clinical manifestation of vitamin B12 deficiency, that we observe with unusual frequency. AIM:To report a series of eleven patients with subacute combined degeneration. PATIENTS AND METHODS:Retrospective analysis of 11 patients hospitalized in a public hospital in Santia...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Nogales-Gaete J,Jiménez P,García P,Sáez D,Aracena R,González J,Lay-Son L,Tenhamm E,Figueroa T,Chávez A,Oelker C,Vega L

    更新日期:2004-11-01 00:00:00

  • [Clinical features of Guillain-Barré syndrome in 41 patients admitted to a public hospital].

    abstract:BACKGROUND:Guillain-Barré syndrome (GBS) is the commonest cause of acute flaccid paralysis worldwide, with an incidence of 0.6-4 per 100.000 inhabitants per year. It affects all age groups and carries an incapacity burden of up to 20%. AIM:To describe the features of GBS in adult Chilean patients admitted to a tertiar...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Cea G,Jara P,Quevedo F

    更新日期:2015-02-01 00:00:00

  • [Current status of cardiac rehabilitation in Chile].

    abstract:BACKGROUND:Cardiac rehabilitation (CR) programs play an important role in the control and prevention of new cardiac events. AIM:A survey was performed to evaluate the current situation of CR programs in Chile. MATERIAL AND METHODS:A questionnaire evaluating the structure of rehabilitation centers, characteristics of ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Santibáñez C,Pérez-Terzic C,López-Jiménez F,Cortés-Bergoderi M,Araya MV,Burdiat G

    更新日期:2012-05-01 00:00:00

  • [Undergraduate medical students' expectative of their desired profile as medical doctors].

    abstract:BACKGROUND:During the last few years, multiple new medical schools have emerged in Chile, associated to the constant preoccupation to provide a good quality medical care. This created the need to evaluate medical training programs and to open a discussion about the attributes that a good physician should have. AIM:To ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: García-Huidobro D,Núñez F,Vargas P,Astudillo S,Hitschfeld M,Gennero R,Salvatierra L,Benavente A

    更新日期:2006-08-01 00:00:00

  • [Microbiology in Chile: development through a century of existence].

    abstract::Microbiology starts in Chile at the end of the XIXth century as part of the effort to develop basic sciences at the University of Chile Medical School. Publications by Vicente Izquierdo on gonorrheae and Alejandro del Río on the organisms of dysenteriae were pioneer works in this area. The field was progressively deve...

    journal_title:Revista medica de Chile

    pub_type: 历史文章,杂志文章


    authors: Rodríguez M

    更新日期:1992-04-01 00:00:00

  • [Scientific ethics and frozen embryos].

    abstract:BACKGROUND:Scientific Ethics is the theory and praxis of decisions. Philosophical Ethics is presented as the theory and praxis of the good. As the good differs among cultures, Philosophical Ethics is dependent on the endo-cultural good conception. The decision (included that one of adhesion or not to a world vision) de...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Valenzuela CY

    更新日期:2001-05-01 00:00:00

  • [Integrons and resistance gene cassettes: structure and role against antimicrobials].

    abstract::Bacteria have developed sophisticated and successful genetic mechanisms to evade the action of antimicrobials. Bacterial multiresistance has caused serious problems in the treatment of nosocomial infections. Integrons and gene cassettes are considered the main genetic elements in the evolution of plasmids and transpos...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审


    authors: González G,Mella S,Zemelman R,Bello H,Domínguez M

    更新日期:2004-05-01 00:00:00

  • [Clinical usefulness of toxicology testing].

    abstract::A toxicology testing is the search by the laboratory of the possible etiologic agents that can cause poisoning. Given the wide variety of substances that can poison a person, the laboratories should work coordinated with the emergency wards in order to determine the appropriate tests menu and the required turn around ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Solari G S,Ríos B JC

    更新日期:2009-10-01 00:00:00

  • [Sexually transmitted diseases: epidemiological characteristics of cases notified in the health service of Viña del Mar-Quillota].

    abstract::During 1987 and 1988 sexually transmitted diseases affected 87.2 per 100,000 inhabitants of the Viña del Mar-Quillota area. At all ages rates were 3.8 times higher in males compared to females. Gonorrhoea, syphilis and non gonorrheal urethritis accounted for most cases. In males, 82% of cases corresponded to gonorrhoe...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Fernández MS,López IM

    更新日期:1991-10-01 00:00:00

  • [Medical coverage of the disease that causes death and place of death in the sixth region of Chile from 1990 to 2003].

    abstract:BACKGROUND:The place of death has changed and coverage of medical attention at death varies according to the development level of countries. AIM:To assess the evolution of coverage of medical attention of the last disease and place of death as indicators of health care quality and development level, in the sixth regio...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Leiva H H,León K F

    更新日期:2007-08-01 00:00:00

  • [Aortic valve replacement with bioprosthesis in patients 70 years old or older with aortic stenosis].

    abstract:BACKGROUND:Aortic valve stenosis is the most prevalent valvulopathy in the elderly, but it is frequently undertreated. AIM:To assess early and long term results of valve replacement with bioprostheses in patients 70 years old or older with aortic stenosis. PATIENTS AND METHODS:A review of the database of the Cardiova...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Zalaquett R,Olivares G,Mejía R,Quezada F,Padilla O,Becker P,Irarrázaval M,Morán S,Muñoz C,González R

    更新日期:2011-02-01 00:00:00

  • [Legalization of medically assisted death: its potential impact on the development of palliative care].

    abstract::In Chile, there are four bills to legalize euthanasia, an act which public surveys report as supported by most of the population. At the legislative, healthcare and social level, there is an active debate about euthanasia, the rights of terminally ill patients and the context of Palliative Care (PC) in the country. Ch...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Dittborn B M,Micolich V C

    更新日期:2020-05-01 00:00:00

  • [Small intestine bacterial overgrowth in patients with chronic pancreatitis].

    abstract:BACKGROUND:Previous reports describe 30-40% of small intestine bacterial overgrowth (SIBO) in patients with chronic pancreatitis (CP), SIBO is a cause of persistent symptoms in this group of patients even when they are treated with pancreatic enzymes. AIM:To asses the frequency of SIBO in patients with CP. PATIENTS A...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Mancilla A C,Madrid S AM,Hurtado H C,Orellana B C,Peña Z M,Tobar A E,Berger F Z

    更新日期:2008-08-01 00:00:00

  • [Small-for-size syndrome. Report of one case].

    abstract::Although the use of cadaveric split or living donor liver transplantation is a valid option for liver transplants, they have several complications, being the "small-for-size syndrome" one of the most frequent. This entity is mainly due to the incapacity that the graft has to meet the blood drainage demands. We report ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Yarur A,Castro L,Segovia R,Roblero JP,Uribe M,Ferrario M,Buckel E

    更新日期:2009-07-01 00:00:00

  • [In vitro comparative activity of moxifloxacin and other antimicrobials against respiratory pathogens].

    abstract:BACKGROUND:Respiratory pathogens are becoming increasingly resistant to antimicrobials. A new group of drugs, called respiratory quinolones have been synthesized to overcome this problem. AIM:To study the in vitro susceptibility of respiratory pathogens to old and new antimicrobials. MATERIALS AND METHODS:Forty five ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Prado V,Giangrieco M,Durán C,Ojeda A,van Flaskamp R

    更新日期:2000-12-01 00:00:00

  • [Concentration of cefotaxime in the exudate from ischemic ulcer after systemic and regional administration].

    abstract::We evaluated the concentration of cefotaxime in the exudate from ischemic leg ulcers in 9 subjects with severe obstructive arterial disease. The administration of the drug was either systemic (1 g in 250 ml of saline given in 30 min) or regional at a vein of the foot while a tourniquet was applied at the level of the ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Acevedo A,Schoop W

    更新日期:1990-03-01 00:00:00

  • [A peek to the origin, functioning and challenges of the new Chilean transplantation system].

    abstract::Chile made several legal, practical and educational changes to the organ donation and transplant system in recent years, to improve its results. However, studies evaluating these reforms and suggesting further corrections are still pending. Our aim is to assess the new regulations and their reception by both the popul...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Zúñiga-Fajuri A,Merino MDP,Urtubia M

    更新日期:2018-06-01 00:00:00

  • [Predictive value of history and physical examination for the diagnosis of community-acquired pneumonia in adults].

    abstract:BACKGROUND:Community-acquired pneumonia in adults is a serious health problem in the ambulatory care setting. AIM:To define clinical variables associated with the presence of pneumonia in adult patients presenting with fever or respiratory symptoms to the emergency department. MATERIAL AND METHODS:Prospective study c...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Saldías P F,Cabrera T D,de Solminihac L I,Hernández A P,Gederlini G A,Díaz F A

    更新日期:2007-02-01 00:00:00

  • [Oral cavity changes in alcoholic patients].

    abstract::The aim of this study was to look for pathological changes in the oral cavity in a group of 40 non cirrhotic male alcoholics, ranging in age from 30 to 40 years old. These subjects were compared with a group of 40 non alcoholic male subjects of similar age. The presence of lip, dental, periodontal, salivary gland and ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章


    authors: Esguep A,Ceballos M,Smith P

    更新日期:1994-02-01 00:00:00