[Small intestine bacterial overgrowth in patients with chronic pancreatitis].

Abstract:

BACKGROUND:Previous reports describe 30-40% of small intestine bacterial overgrowth (SIBO) in patients with chronic pancreatitis (CP), SIBO is a cause of persistent symptoms in this group of patients even when they are treated with pancreatic enzymes. AIM:To asses the frequency of SIBO in patients with CP. PATIENTS AND METHODS:We studied 14 patients with CP using an hydrogen breath test with lactulose to detect SIBO, a nonabsorbable carbohydrate, whose results are not influenced by the presence of exocrine insufficiency. Main symptoms and signs were bloating in 9 (64%), recurrent abdominal pain in 8 (57%), intermittent diarrhea in 5 (36%) and steatorrhea in 5 (36%). At the same time we studied a healthy control group paired by age and sex. RESULTS:SIBO was present in 13 of 14 patients with CP (92%) and in 1 of 14 controls (p<0.001). The only patient with CP and without SIBO was recently diagnosed and had minimal morphologic alterations in computed tomography and endoscopic pancreatography. CONCLUSIONS:SIBO is common in CP and may be responsible for persistent symptoms. Proper diagnosis and treatment could alleviate symptoms and improve quality of Ufe.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Mancilla A C,Madrid S AM,Hurtado H C,Orellana B C,Peña Z M,Tobar A E,Berger F Z

doi

/S0034-98872008000800003

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

976-80

issue

8

eissn

0034-9887

issn

0717-6163

pii

S0034-98872008000800003

journal_volume

136

pub_type

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