Recurrent vulvovaginal candidiasis associated with long-term tamoxifen treatment in postmenopausal women.

Abstract:

BACKGROUND:Symptomatic vulvovaginal candidiasis is rare in postmenopausal subjects because of the estrogen-dependence of this infection. Tamoxifen, a breast-cancer cell estrogen-antagonist, has not previously been reported to predispose to vulvovaginal candidiasis. CASES:Three postmenopausal women, age range 60-81 years (mean 71), were identified with recurrent vulvovaginal candidiasis. In all three cases, new onset of recurrent vulvovaginal candidiasis followed daily tamoxifen therapy. The duration of prior tamoxifen therapy was 1-7 years (mean 3.5). One patient had diabetes mellitus, an additional risk factor for vulvovaginal candidiasis. In all three patients, Candida glabrata was identified as the causal pathogen, although in two patients symptomatic episodes caused by Candida albicans also occurred. In all cases, diagnosis was easily established using conventional investigations, and eradication of vulvovaginal candidiasis was possible without cessation of tamoxifen. CONCLUSION:Long-term tamoxifen treatment may be complicated by recurrent vulvovaginal candidiasis in postmenopausal women.

journal_name

Obstet Gynecol

authors

Sobel JD,Chaim W,Leaman D

doi

10.1016/0029-7844(96)00123-8

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

704-6

issue

4 Pt 2

eissn

0029-7844

issn

1873-233X

journal_volume

88

pub_type

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