当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Experimental autoimmune myositis in SJL/J mice produced by immunization with syngeneic myosin B fraction. Transfer by both immunoglobulin G and T cells.

Experimental autoimmune myositis in SJL/J mice produced by immunization with syngeneic myosin B fraction. Transfer by both immunoglobulin G and T cells.

Abstract：

:An experimental autoimmune myositis (EAM) was produced by immunizing SJL/J mice with the myosin B (MB) fraction of the syngeneic muscle. Immunoblot analysis of the IgG of the EAM mice demonstrated antibodies against a variety of muscle proteins. The condition was then transferred to normal mice by both injecting immunoglobulin G or T cells from the EAM mice. This is the first model of transferrable EAM caused by syngeneic muscle fraction, and it has an unique resemblance to human inflammatory myopathies involving both humoral and cellular immune mechanisms.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Matsubara S,Okumura S

doi

10.1016/s0022-510x(96)00223-7

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

171-5

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(96)00223-7

journal_volume

144

pub_type

杂志文章

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