当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Burden of non-motor symptoms in unclear parkinsonism and tremor: A study with [123I]FP-CIT SPECT.

Burden of non-motor symptoms in unclear parkinsonism and tremor: A study with [123I]FP-CIT SPECT.

Abstract：

BACKGROUND:Non-motor symptoms (NMSs) are clearly more prevalent in Parkinson's disease (PD) patients compared to healthy individuals. However, NMSs are also common in the elderly and other neurological conditions, and thus, it is not known whether NMSs could be used to differentiate PD from parkinsonism/tremor without dopamine deficiency. METHODS:We prospectively evaluated NMSs immediately before brain dopamine transporter (DAT) [123I]FP-CIT SPECT scanning in 193 patients with unclear parkinsonism/tremor. According to the clinical follow-up and imaging results, 84 patients had PD. NMSs and their correlations with striatal DAT binding were investigated in PD patients and in parkinsonism/tremor patients with normal dopamine function. RESULTS:Total NMS burden, anxiety or depression did not differ between PD patients and patients with normal DAT binding. DAT-normal patients reported more perception-related (p = 0.045) and attention/memory-related NMSs than PD patients (p < 0.001). Total NMS score did not correlate with striatal DAT binding in either group. CONCLUSIONS:In clinically uncertain cases, the total NMS burden cannot be used as a tool in distinguishing PD patients from patients with non-dopaminergic parkinsonism/tremor. Clinical screening of NMSs appears equally important in all patients with parkinsonism.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Jaakkola E,Joutsa J,Mäkinen E,Noponen T,Pitkonen M,Levo R,Mertsalmi T,Scheperjans F,Kaasinen V

doi

10.1016/j.jns.2019.07.025

subject

Has Abstract

pub_date

2019-09-15 00:00:00

pages

124-127

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(19)30328-4

journal_volume

404

pub_type

杂志文章

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