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Oxidative injury is present in Purkinje cells in patients with olivopontocerebellar atrophy.

Abstract：

:To verify the presence of lipid peroxidation products in spinocerebellar degeneration (SCD), the cerebella from eight patients with olivopontocerebellar atrophy (OPCA) and six non-OPCA patients were immunohistochemically investigated with 4-hydroxy-2-nonenal (HNE) antibody. On average, 84.6% of Purkinje cells were positively or strongly positively immunostained in OPCA patients while only 15.5% were positive in non-OPCA patients. Other cells in the molecular and granular layers showed no obvious immunoreactivity. These data suggest that a lipid peroxidation product is present in Purkinje cells of OPCA patients and that oxidative stress may play an important role in the degeneration process of SCD.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Yamashita T,Ando Y,Obayashi K,Terazaki H,Sakashita N,Uchida K,Ohama E,Ando M,Uchino M

doi

10.1016/s0022-510x(00)00296-3

subject

Has Abstract

pub_date

2000-04-15 00:00:00

pages

107-10

issue

2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(00)00296-3

journal_volume

175

pub_type

杂志文章

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