Erythrocyte membrane abnormalities in patients with amyotrophic chorea with acanthocytosis. Part 1. Spin labeling studies and lipid analyses.

Abstract:

:Low fluidity was observed in the erythrocyte membranes of familial chorea-acanthocytosis by spin labeling with 12NS. The high content of the saturated fatty acids support the finding of low fluidity. Other lipid contents (cholesterol and phospholipids) and the cholesterol/phospholipid ratio were within normal ranges. The sharp decrease in the parameter, (h0/h-1)1/2, suggests phase separation deep inside the patients' erythrocyte membrane matrix. This distortion of the membrane matrix may be caused by membrane components other than the lipid components.

journal_name

J Neurol Sci

authors

Oshima M,Osawa Y,Asano K,Saito T

doi

10.1016/0022-510x(85)90096-6

subject

Has Abstract

pub_date

1985-05-01 00:00:00

pages

147-60

issue

2-3

eissn

0022-510X

issn

1878-5883

pii

0022-510X(85)90096-6

journal_volume

68

pub_type

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