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Upstream regulators and downstream effectors of NF-κB in Alzheimer's disease.

Abstract：

:Since Alzheimer's disease (AD) is becoming the prevalent dementia in the whole world, more underlying mechanisms are emerging. Long time has the transcription factor NF-κB been identified to participate in AD pathogenesis, various studies have focused on the causes and effects of AD that are linked to NF-κB. In this review we discuss diverse environmental stimuli including oxidative stress, neuroinflammation and metabolism, involved signaling pathways such as PI3K/AKT, MAPK and AGE/RAGE/GSK-3 and newly found ncRNAs that mediate neuron toxicity or neuron protection through NF-κB activation and the following response associated with the same factors in AD. These may provide future orientation of investigation at transcription level and support efficient treatment to AD by a better understanding of the upstream regulators and downstream effectors of NF-κB.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Shi ZM,Han YW,Han XH,Zhang K,Chang YN,Hu ZM,Qi HX,Ting C,Zhen Z,Hong W

doi

10.1016/j.jns.2016.05.022

subject

Has Abstract

pub_date

2016-07-15 00:00:00

pages

127-134

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(16)30281-7

journal_volume

366

pub_type

杂志文章,评审

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