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SIRT2 polymorphism rs10410544 is associated with Alzheimer's disease in a Han Chinese population.

Abstract：

:Sirtuin 2 (SIRT2) is a strong protein deacetylase, which is highly expressed in central nervous system. Recently, an association between SIRT2 rs10410544 polymorphism and late-onset Alzheimer's disease (LOAD) was found in the APOEε4-negative Caucasian population. To investigate the potential association between the rs10410544 C/T polymorphism of SIRT2 and the risk of LOAD, we conducted an independent replication case-control study in a Northern Han Chinese population comprising 1133 cases and 1159 healthy controls being matched for age and gender. The results revealed that there were significant differences in genotype and allele frequencies between LOAD cases and controls (genotype P=0.008, allele P=0.009). When compared with the C allele, the T allele of rs10410544 demonstrated a 1.709-fold risk for developing LOAD. After stratification by apolipoprotein E (APOE) ε4-carrying status, only APOEε4 noncarriers (P=0.035, adjusted OR=1.656, 95% CI: 1.036-2.647) showed the relation between LOAD and SIRT2 rs10410544 T allele. This study provides the evidence that the rs10410544 C/T polymorphism of SIRT2 was associated with genetic susceptibility to LOAD in a Northern Han Chinese population.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Xia M,Yu JT,Miao D,Lu RC,Zheng XP,Tan L

doi

10.1016/j.jns.2013.10.001

subject

Has Abstract

pub_date

2014-01-15 00:00:00

pages

48-51

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(13)02947-X

journal_volume

336

pub_type

杂志文章

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