当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Enriched environment induces angiogenesis and improves neural function outcomes in rat stroke model.

Enriched environment induces angiogenesis and improves neural function outcomes in rat stroke model.

Abstract：

:Increasing evidence shows that exposure to an enriched environment (EE) after cerebral ischemia/reperfusion injury has neuroprotective benefits in animal models, including enhancing functional recovery after ischemic stroke. However, the mechanism underlying this effect remains unclear. To clarify this critical issue, the current study investigated the effects of EE on the improvement of damaged neural function and the induction of angiogenesis. Adult rats were subjected to ischemia induced by middle cerebral artery occlusion followed by reperfusion. Neurological status scores were used to evaluate neural function on postoperative days 2, 7, and 14. A beam-walking task was used to test the recovery of motor behavior on postoperative days 2, 5, 10, and 15. We also used a Morris water maze task to examine whether EE protected learning and memory performance. The specific marker of angiogenesis of CD31 was examined by western blot. Angiogenesis around the peri-infarction region was assayed by laser scanning confocal microscopy (LSCM) after 14 days of EE exposure starting 24h after ischemia. Neurological status scores of animals in the EE group were significantly higher than those in the standard housing condition (SC) control group from the seventh day after ischemic. EE accelerated the recovery of motor coordination and integration and also improved learning and memory performance after cerebral ischemia. Furthermore, EE increased CD31 levels and promoted angiogenesis of cortex in the peri-infarction region compared to the SC group. Neural function outcomes are positively correlated with post-ischemia angiogenesis. These findings suggest that EE plays an important role in the recovery of damaged neural function via regulation of angiogenesis after ischemia.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Yu K,Wu Y,Zhang Q,Xie H,Liu G,Guo Z,Li F,Jia J,Kuang S,Hu R

doi

10.1016/j.jns.2014.10.022

subject

Has Abstract

pub_date

2014-12-15 00:00:00

pages

275-80

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(14)00675-3

journal_volume

347

pub_type

杂志文章

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Does ethanol damage the blood--brain barrier?

    abstract：:The permeability of the blood--brain barrier has been measured using a technique which is independent of blood flow and is sufficiently accurate to monitor the penetration of weakly permeant substances. The permeability of the blood--brain barrier to [14C]sucrose has been measured in rats anaesthetised with either ure...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(81)90043-5

    authors： Phillips SC

    更新日期：1981-04-01 00:00:00

  • Updates on Somatoform Disorders (SFMD) in Parkinson's Disease and Dementia with Lewy Bodies and discussion of phenomenology.

    abstract：:Somatoform Disorders (SFMD) were recently described in Parkinson Disease (PD) and Dementia with Lewy Bodies (DLB). The present paper updates the observations in our cohort of patients and further details clinical phenomenology. Of 3178 patients consecutively referred to our Institutions from 1999, 1572 subjects had ne...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.07.010

    authors： Onofrj M,Thomas A,Tiraboschi P,Wenning G,Gambi F,Sepede G,Di Giannantonio M,Di Carmine C,Monaco D,Maruotti V,Ciccocioppo F,D'Amico MC,Bonanni L

    更新日期：2011-11-15 00:00:00

  • Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease.

    abstract：:Preclinical evidence strongly indicate that adenosine A(2A) receptor antagonists represent a promising class of drugs for the treatment of motor deficits associated to Parkinson's disease. The effects of adenosine A(2A) receptor antagonists were here assessed in a rat model of parkinsonian tremor induced by cholinomim...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2006.05.038

    authors： Simola N,Fenu S,Baraldi PG,Tabrizi MA,Morelli M

    更新日期：2006-10-25 00:00:00

  • Diffusion-weighted imaging in Wallerian degeneration.

    abstract：:We report two patients displaying hyperintensities on diffusion-weighted imaging (DWI) in the area of Wallerian degeneration (WD) at 12 days after stroke. High signal intensities were more conspicuous on DWI than on T2-weighted images. Both patients showed decreased diffusion anisotropy resulting in elevated apparent ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(00)00373-7

    authors： Kang DW,Chu K,Yoon BW,Song IC,Chang KH,Roh JK

    更新日期：2000-09-15 00:00:00

  • Preservation of the C-terminus of dystrophin molecule in the skeletal muscle from Becker muscular dystrophy.

    abstract：:Duchenne muscular dystrophy (DMD) is a fatal X-linked recessive disorder of muscle in children. The DMD gene product, "dystrophin", is absent from DMD, while the allelic disease, Becker muscular dystrophy (BMD), exhibits dystrophin of abnormal size and/or quantity. But we are still uncertain about the scenario that in...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(91)90039-a

    authors： Arahata K,Beggs AH,Honda H,Ito S,Ishiura S,Tsukahara T,Ishiguro T,Eguchi C,Orimo S,Arikawa E

    更新日期：1991-02-01 00:00:00

  • Post-streptococcal 'complex' movement disorders: unusual concurrence of psychogenic and organic symptoms.

    abstract：:Post-streptococcal neuropsychiatric disorders encompass a broad spectrum of movement disorders, including tics, stereotypies, dystonia and tremor. We report the case of a 15-year-old boy who presented with a relapsing-remitting combination of psychogenic and organic movement disorders. Both relapses occurred after an ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2009.10.004

    authors： Squintani G,Tinazzi M,Gambarin M,Bravi E,Moretto G,Buttiglione M,Defazio G,Martino D

    更新日期：2010-01-15 00:00:00

  • Late appearance of acanthocytes during the course of chorea-acanthocytosis.

    abstract：:A case of chorea-acanthocytosis (CA) syndrome is described. The presence of acanthocytes has usually been considered an important diagnostic marker of CA. However, it is not specific and other neurological diseases have to be considered. In the present report we rule out other diagnostic possibilities and show that th...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(99)00005-2

    authors： Sorrentino G,De Renzo A,Miniello S,Nori O,Bonavita V

    更新日期：1999-03-01 00:00:00

  • Personality in Parkinson's disease: Clinical, behavioural and cognitive correlates.

    abstract：:Affective disorders and personality changes have long been considered pre-motor aspects of Parkinson's disease (PD). Many authors have used the term "premorbid personality" to define distinctive features of PD patients' personality characterized by reduced exploration of new environmental stimuli or potential reward s...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2017.01.013

    authors： Santangelo G,Piscopo F,Barone P,Vitale C

    更新日期：2017-03-15 00:00:00

  • Myoadenylate deaminase deficiency or not? Observations on two brothers with exercise-induced muscle pain.

    abstract：:This paper describes 2 brothers with increasingly severe exercise-induced muscle pain and stiffness, beginning in adolescence. Histochemical studies showed that myoadenylate deaminase activity was absent in the propositus, but present in his younger brother. Biochemical examination of muscle homogenates confirmed thes...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(82)90086-7

    authors： Hayes DJ,Summers BA,Morgan-Hughes JA

    更新日期：1982-01-01 00:00:00

  • Profound cerebrospinal fluid pleocytosis and Froin's Syndrome secondary to widespread necrotizing vasculitis in an HIV-positive patient with varicella zoster virus encephalomyelitis.

    abstract：:Demonstration of the direct involvement of cranial blood vessels by varicella zoster virus (VZV) is facilitated by immunohistochemistry (IHC), in situ hybridization (ISH) and polymerase chain reaction (PCR) techniques. The extent to which an inflammatory vasculitis serves as the pathogenic mechanism for VZV encephalom...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(98)00171-3

    authors： Kleinschmidt-DeMasters BK,Mahalingam R,Shimek C,Marcoux HL,Wellish M,Tyler KL,Gilden DH

    更新日期：1998-08-14 00:00:00

  • Characterization of membrane markers of isolated oligodendrocytes and clonal lines of the nervous system.

    abstract：:We show here that the major glycolipid in myelin, galactocerebroside, is not only a useful marker for isolated bovine oligodendrocytes but that its quantitation can serve as a probe for cell differentiation. We have produced in the rabbit antisera to bovine oligodendroglia, bovine myelin and galactocerebroside. The bi...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(80)90032-5

    authors： Steck AJ,Perruisseau G

    更新日期：1980-07-01 00:00:00

  • Accumulation of HAX-1 and PARL in brainstem- and cortical-type Lewy bodies in Parkinson's disease and dementia with Lewy bodies.

    abstract：:HS1-associated protein X-1 (HAX-1) and presenilin-associated rhomboid-like protein (PALR) were reported to play an important role in the activation of HtrA2/Omi, which is also designated PARK13, in the mitochondria. To elucidate the role of HAX-1 and PARL in patients with Parkinson's disease (PD) and dementia with Lew...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2020.116928

    authors： Kawamoto Y,Ayaki T,Urushitani M,Ito H,Takahashi R

    更新日期：2020-08-15 00:00:00

  • Defective electron transfer in complexes I and IV in patients with aceruloplasminemia.

    abstract：:Aceruloplasminemia is a disorder of iron metabolism caused by mutations in the ceruloplasmin gene. It is characterized by progressive neurodegeneration of the retina, basal ganglia, dentate nucleus and cerebral cortex in association with iron accumulation in these tissues. Enzyme activities in the mitochondrial respir...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(00)00452-4

    authors： Kohno S,Miyajima H,Takahashi Y,Suzuki H,Hishida A

    更新日期：2000-12-15 00:00:00

  • Effect of thyroxine on the development of somatosensory and visual evoked potentials in the rat.

    abstract：:The thyroid hormone thyroxine (T4), administered post-natally to neonatal rats, has been shown to accelerate development of auditory function, as expressed by auditory nerve-brainstem evoked responses. This study investigated whether this earlier development was also reflected in other sensory modalities. Rat pups wer...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(94)00229-h

    authors： Freeman S,Sohmer H

    更新日期：1995-02-01 00:00:00

  • MRI confirms mild cognitive impairments prodromal for Alzheimer's, vascular and Parkinson-Lewy body dementias.

    abstract：OBJECTIVES:MRI assessments were correlated with serial Combined Mini-Mental Cognitive Capacity Screening Examinations (CMC). Vascular-MCI (VMCI), Neurodegenerative MCI (NMCI) and Parkinson-Lewy body MCI (PLB-MCI) were compared during conversions to dementia. Mild cognitive impairments (MCI) are identifiable prodromes f...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2007.01.016

    authors： Meyer JS,Huang J,Chowdhury MH

    更新日期：2007-06-15 00:00:00

  • Familial intermittent ataxia with possible X-linked recessive inheritance. Two patients with abnormal pyruvate metabolism and a response to acetazolamide.

    abstract：:Five males in one kindred suffered from intermittent ataxia and one female may have been more mildly affected. The pattern of inheritance strongly suggests X-linkage. Cerebral pathology in one case had some features of Leigh's disease. A defect in pyruvate metabolism was found in two cases. Acetazolamide gave a tempor...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(84)90059-5

    authors： Livingstone IR,Gardner-Medwin D,Pennington RJ

    更新日期：1984-04-01 00:00:00

  • Frontal-lobe syndrome and psychosis after damage to the brainstem dopaminergic nuclei.

    abstract：:A patient developed frontal-lobe syndrome and psychotic symptoms after infarction in the pontomesencephalic junction. Stereotaxic lesion localization on magnetic resonance imaging and statistical analyses of regional cerebral blood flow (rCBF) disclosed an involvement of the rostral brainstem dopaminergic nuclei and h...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2007.04.021

    authors： Nishio Y,Ishii K,Kazui H,Hosokai Y,Mori E

    更新日期：2007-09-15 00:00:00

  • Can amyotrophic lateral sclerosis patients with respiratory insufficiency exercise?

    abstract：:The authors have shown in a recent paper that survival with amyotrophic lateral sclerosis (ALS) can be increased by the use of non-invasive methods of assisted ventilation (Bipap). However, the progression of muscle weakness was not affected and the quality of life was not positively enhanced. In ALS, reduced physical...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0022-510x(99)00218-x

    authors： Pinto AC,Alves M,Nogueira A,Evangelista T,Carvalho J,Coelho A,de Carvalho M,Sales-Luís ML

    更新日期：1999-10-31 00:00:00

  • Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death.

    abstract：:Neurodegenerative disorders are marked by extensive neuronal apoptosis and gliosis. Although several apoptosis-inducing agents have been described, understanding of the regulatory mechanisms underlying modes of cell death is incomplete. A major breakthrough in delineation of the mechanism of cell death came from eluci...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2008.12.010

    authors： Jana A,Hogan EL,Pahan K

    更新日期：2009-03-15 00:00:00

  • Adult-onset leukodystrophy with axonal spheroids.

    abstract：:We report two cases of adult-onset leukodystrophy with axonal spheroids in a brother and sister, one with an autopsy, the other with a cerebral biopsy. Symptoms developed at 24 and 33years. The sister died within four years, her brother in 2 and a half. Her brain showed a large lesion in the frontal centrum semiovale ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.06.027

    authors： Mendes A,Pinto M,Vieira S,Castro L,Carpenter S

    更新日期：2010-10-15 00:00:00

  • CaMKII antisense oligodeoxynucleotides protect against ischemia-induced neuronal death in the rat hippocampus.

    abstract：:The present study was performed to investigate the effects of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) antisense oligodeoxynucleotides (ODNs) on the assembly of the CaMKII·GluR6·PSD-95 signaling module, GluR6 serine phosphorylation and c-Jun N-terminal kinase 3 (JNK3) activation. A further aim was to det...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.10.012

    authors： Liu Z,Xu J,Shen X,Lv C,Xu T,Pei D

    更新日期：2012-03-15 00:00:00

  • Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases.

    abstract：:We assayed IL-6 in 105 cerebrospinal fluid (CSF) samples from patients with ALS, MS, HTLV-1 associated myelopathy (HAM), and controls. There was considerable overlap in IL-6 levels in all patient groups. The mean IL-6 in 27 patients with ALS was significantly higher than in 21 patients in the other neurological diseas...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0022-510x(97)00228-1

    authors： Sekizawa T,Openshaw H,Ohbo K,Sugamura K,Itoyama Y,Niland JC

    更新日期：1998-02-05 00:00:00

  • Anoxia in vitro does not induce neuronal swelling or death.

    abstract：:To improve the understanding of neuronal cell swelling in cerebral ischemia, cell volume regulation, viability, intracellular electrolytes, and lactate production of Neuro-2A neuroblastoma cells were studied using an in vitro model. The volume regulatory capacity of Neuro-2A cells was assessed after incubation in hypo...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：

    authors： Mackert BM,Staub F,Peters J,Baethmann A,Kempski O

    更新日期：1996-07-01 00:00:00

  • Untapped targets in multiple sclerosis.

    abstract：:Multiple sclerosis is a chronic inflammatory disease of the white and grey matter which results in irrevocable axonal and neuronal damage. Grey matter injury is widespread and reflects disability to a greater extent than do white matter lesions. Growing understanding of the immunopathology of multiple sclerosis is lea...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/S0022-510X(11)70003-X

    authors： Meinl E

    更新日期：2011-12-01 00:00:00

  • A unique episode of REM sleep behavior disorder triggered during surgery for Parkinson's disease.

    abstract：:REM sleep behavior disorder (RBD) is characterized by vigorous movements during REM sleep. Here, the authors report the case of a patient who presented such a disorder immediately after the implantation of the definitive electrode for left subthalamic stimulation. Interestingly, this was and has remained a unique epis...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2006.11.005

    authors： Piette T,Mescola P,Uytdenhoef P,Henriet M,Vanderkelen B,Jacquy J,Seeldrayers P,Godaux E

    更新日期：2007-02-15 00:00:00

  • The effect of repetitive transcranial magnetic stimulation on motor performance, fatigue and quality of life in amyotrophic lateral sclerosis.

    abstract：BACKGROUND:The treatment of amyotrophic lateral sclerosis (ALS) is still disappointing. Repetitive transcranial magnetic stimulation (rTMS) has been suggested to modify the rate of disease progression in ALS. OBJECTIVE:In a pilot controlled study, we tested the effect of 5-Hz rTMS on motor performance, fatigue and qua...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2008.01.011

    authors： Zanette G,Forgione A,Manganotti P,Fiaschi A,Tamburin S

    更新日期：2008-07-15 00:00:00

  • Painful legs and moving toes syndrome associated with herpes zoster myelitis.

    abstract：:A 75-year-old woman developed painful legs and moving toes syndrome (PLMT) 16 months after the onset of herpes zoster (HZ) myelitis. Although the scattered extensive lesions due to HZ myelitis were observed to be eccentric near the posterior horn on MRI, these changes had disappeared upon the development of PLMT. Comb...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2004.01.011

    authors： Ikeda K,Deguchi K,Touge T,Sasaki I,Tsukaguchi M,Shimamura M,Komatsu E,Takeuchi H,Kuriyama S

    更新日期：2004-04-15 00:00:00

  • Cognitive impairment and hypothymia in post stroke patients.

    abstract：:129 patients aged 18-84 in early rehabilitation period of the first hemispheric ischemic stroke and 48 patients with cerebrovascular disorders without stroke in anamnesis were observed. Cognitive functions (MMSE, FAB, Clock Drawing Test, the 5-Word test, attention assessment, Semantic Verbal Fluency test) and emotiona...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2012.11.013

    authors： Pustokhanova L,Morozova E

    更新日期：2013-02-15 00:00:00

  • First report of two Taiwanese siblings with sialidosis type I: a 10-year follow-up study.

    abstract：:We report the clinical features, electrophysiological findings and genetic characteristics of the first two Taiwanese siblings ever reported with sialidosis type I. We also provide a 10-year follow-up result. Enzymological analysis revealed a primary sialidase deficit. The back-averaged electroencephalography demonstr...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2006.03.013

    authors： Chen CM,Lai SC,Chen IC,Hsu KC,Lyu RK,Ro LS,Chang HS

    更新日期：2006-08-15 00:00:00

  • Vascular dementia among elderly Arabs in Wadi Ara.

    abstract：:Dementia of the Alzheimer type (DAT) and vascular dementia (VaD) are the two major subtypes of dementia. In our epidemiological study of DAT in an Arab community in Wadi Ara, Israel, we found a high prevalence of late onset DAT. Illiteracy, smoking, diabetes mellitus (DM) and hypertension are very frequent in Wadi Ara...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(02)00269-1

    authors： Bowirrat A,Friedland RP,Korczyn AD

    更新日期：2002-11-15 00:00:00