Abstract:
BACKGROUND:Ischemic stroke is one of the most common causes of death worldwide. Early and accurate prediction of outcome in acute ischemic stroke (AIS) is important and influences risk-optimized therapeutic strategies. We investigated the changes in high-sensitivity C-reactive protein (Hs-CRP) and homocysteine (HCY) levels, two of the risk factors, during the acute period of AIS and evaluated the relationship between these levels and short-term prognosis. METHODS:We prospectively studied 189 patients with AIS who were admitted within 24 hours after the onset of symptoms. Serum Hs-CRP, HCY levels, and National Institutes of Health Stroke Scale (NIHSS) were measured at the time of admission. Short-term functional outcome was measured by the modified Rankin scale (mRS), 90 days after admission. RESULTS:The median serum Hs-CRP and HCY levels were significantly higher in AIS patients as compared to normal controls (P < 0.0001, respectively). High-sensitivity C-reactive protein and HCY were independent prognostic markers of functional outcome and death (adjusted for age and the NIHSS) in patients with AIS. In receiver operating characteristic curve analysis, the prognostic accuracy of the combined model (HCY and Hs-CRP) was higher compared to all measured biomarkers individually and the NIHSS score. CONCLUSION:High-sensitivity C-reactive protein and HCY are independent predictors of short-term outcome and mortality after AIS. The combined model may provide additional general prognostic information.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Tu WJ,Zhao SJ,Liu TG,Yang DG,Chen Hdoi
10.1179/1743132813Y.0000000228subject
Has Abstractpub_date
2013-11-01 00:00:00pages
912-21issue
9eissn
0161-6412issn
1743-1328pii
ner3222journal_volume
35pub_type
杂志文章abstract::Background The distribution of risk factors for stroke is related to gender and age. The main objective of study was to determine the type and frequency of stroke risk factors in patients with first-in-life stroke before the age of 50. Methods Our study included patients under the age of 50 with first-in-life stroke. ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1455367
更新日期:2018-07-01 00:00:00
abstract::In this study the pulsation-pressure relationship in an experimental model of aneurysms was analyzed. In addition, we have examined pulsatility of the aneurysmal wall reinforced by Guglielmi Detachable Coils (GDC). Bifurcation (BAn), aneurysms (LAn) and bilobar (BiA) aneurysms were produced in 15 mongrel dogs. The ane...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740440
更新日期:1996-08-01 00:00:00
abstract::The frequency of skull metastasis from hepatocellular carcinoma (HCC) is increasing together with the recent progress in the management of the primary lesion. Cases are often complicated with poor general conditions or metastasis to the other organs, and not readily indicated for surgery. A direct injection of ethanol...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740593
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:After a spinal cord injury (SCI), most men experience fertility related problems including poor semen quality in which decreased sperm viability and motility, have been proposed to be related to the accessory sex glands dysfunction. In this study, we investigated the probable effects of SCI on the seminal ves...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164108X268287
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To explore the primary regularity of cerebral electrical impedance (CEI) change in healthy people, patients with intracerebral hemorrhage (ICH) and patients with cerebral infarction (CI). METHODS:CEI of 200 healthy volunteers, 78 patients with ICH and 51 patients with CI were measured by noninvasive brain-ed...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164106X91843
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:It is not fully understood how the stimulus/response curves obtained by transcranial magnetic stimulation (TMS) reflect the function of the cortico-motoneuronal (CM) and spinal motoneuronal (SM) systems in healthy subjects. To understand these response functions, we studied patients with amyotrophic lateral s...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164108X323717
更新日期:2008-12-01 00:00:00
abstract::Decreased metabolic rate may precede cognitive impairment in Alzheimer's disease (AD) and is thus an early occurring hallmark. Several observations in post-mortem brain indicate that activated neurons are better able to withstand aging and AD, a phenomenon paraphrased by us as 'use it or lose it'. Moreover, a number o...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164103101201959
更新日期:2003-09-01 00:00:00
abstract::A 51-year-old man presented with loss of consciousness when he underwent urological examination at another hospital. CT scans showed subarachnoid hemorrhage, and cerebral angiography showed bilateral dissecting aneurysms of the vertebral arteries. Following ventricular drainage, the lesion was managed conservatively w...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200825
更新日期:2002-12-01 00:00:00
abstract::Our goal was to clarify the optimum management of the inaccessible unruptured giant and large aneurysms of the internal carotid artery (ICA). Since 1981, we have treated 18 patients with unclippable unruptured giant or large aneurysms of the ICA. Aneurysms were classified as either intracavernous or intradural. We per...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101198604
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Traumatic brain injuries (TBIs) cause a substantial burden to the patient, relatives, and the society as a whole. Much experience and knowledge during the last two decades have improved the neurosurgical treatment as well as the outcome. However, there is still much debate on what actually happens when exter...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000227
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:Glutamate antagonists are very attractive drugs in laboratory works to protect neural tissue against ischemia. In this work, the effects of magnesium, MK-801 and combination of magnesium and MK-801 on blood-brain barrier (BBB) and brain edema after experimentally induced traumatic brain injury are evaluated. ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X385617
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:The actual relationship between neural stem cells and SDF-1alpha/CXCR4 after brain injury has not yet been elucidated, although recent studies have speculated that stromal cell-derived factor-1alpha (SDF-1alpha) and its receptor, CXCR4, could contribute to neural stem cells migration after brain injury. In th...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X332995
更新日期:2009-02-01 00:00:00
abstract::Following cerebral ischemia, the extracellular concentration of excitatory amino acids increases, and the excitatory cell death may play an important role contributing to ischemic neuronal damage. Although sequential metabolic changes in permanent local cerebral ischemia have been reported, the effect of reperfusion i...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740462
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:To determine the functional abnormalities of the Leu89Pro mutation in connexin32 (CX32), which we have previously reported is present within an X-linked dominant Charcot-Marie-Tooth disease family. In this family, male patients were moderately to severely affected. METHODS:We performed immunofluorescence to ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1204494
更新日期:2016-10-01 00:00:00
abstract::The therapeutic effect of insulin alone or insulin combined with 30 min delayed thrombolytic therapy was investigated in rats embolized in the right hemisphere with a fibrin clot made from autologous blood. Animals were killed seven days after embolization and the infarct volumes were measured in % of the affected hem...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200096
更新日期:2002-06-01 00:00:00
abstract::Recent evidence indicates that different vascular risk factors are present in Alzheimer's disease (AD) and other prevalent dementia types probably contributing to deterioration of cerebrovascular function, thus enhancing neurodegeneration and premature neuronal death due to a reduction in brain perfusion. Brain blood ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164103101202002
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:To explore whether intracranial pulse pressure amplitudes relate to arterial pulse pressure amplitudes and whether correlations between time-related changes in intracranial and arterial pulse pressure amplitudes associate with indices of cerebral autoregulation. METHODS:A total of 257 continuous and simultan...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X172167
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:Patients presenting to the emergency room with an acute or subacute onset of focal neurological deficits are evaluated initially by non-contrast computed tomogram (CT) of the brain. This is primarily carried out to differentiate an ischemic from hemorrhagic stroke. However, other neurological conditions may ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164109X12445505689607
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:One of the important causes of failed back surgery is the extensive peridural fibrosis collecting in the surgical field after spinal surgeries. Today we know that inflammatory mechanisms mediated by the immune system of the body plays an important role in generation of fibrosis. Azithromycin, a macrolide anti...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164110X12767786356471
更新日期:2011-05-01 00:00:00
abstract:INTRODUCTION:Cerebrospinal fluid (CSF) oligoclonal bands (OB) imply intrathecal immunoglobulin synthesis and B-cell immune process. There is scarce evidence of OB having a role in disease prognosis. The objective of the present study was to determine OB's prognostic value regarding disease progression. METHODS:Betwee...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000088
更新日期:2012-11-01 00:00:00
abstract::Aspirin therapy for stroke prophylaxis in low risk patients has paradoxically demonstrated an increased risk of ischemic stroke in several studies. Moreover, the MAST-Italy trial reported a near doubling of mortality with the addition of aspirin to thrombolytics while experimentally, we have noted that aspirin antagon...
journal_title:Neurological research
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
abstract::The aim of this study was to examine the pre-operative clinical and neuromonitoring courses in patients with a decompressive craniectomy to assess and to compare clinical and neuromonitoring signs indicating extensive cerebral edema. We conducted a retrospective analysis of the clinical signs and courses of simultaneo...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101201742
更新日期:2003-07-01 00:00:00
abstract::The possibility of the evaluation of ischemia solely by the momentary values of regional cerebral blood flow (rCBF) was investigated. Ischaemic damage was evaluated histopathologically and by observing albumin extravasation. Unilateral carotid clippings were performed for 1 h and the gerbils evaluated with regard to t...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1988.11739846
更新日期:1988-12-01 00:00:00
abstract::Corticotrophin releasing factor has been shown in several models of tissue injury to be an effective treatment for edema. In a previous study we demonstrated this ability in two models of traumatic brain injury (TBI). The aim of this study was to assess whether human corticotrophin releasing factor (hCRF) could additi...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2000.11740737
更新日期:2000-10-01 00:00:00
abstract::Various surgical approaches have been described for treating lesions which arise in the sellar region. The popular transnasal-transsphenoidal and transethmoidal-transsphenoidal approaches avoid the morbidity associated with transcranial operations while allowing enough exposure to successfully remove most lesions that...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101198280
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:The feasibility of high resolution CT imaging for evaluating experimentally-induced brain tumors in rats was assessed. METHODS:The gliosarcoma cell line (9 L/lacZ) was inoculated in 34 male Fischer 344 rats and CT studies were performed prior to and at 4, 7, 9, 12 and 14 days post-tumor cell implantation. Br...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X18250
更新日期:2005-01-01 00:00:00
abstract::It has been established that following injury to the central nervous system two types of damage take place, the initial insult and the secondary response to injury. This review will focus on the secondary molecular aspects of neurotrauma. These responses may be either deleterious or have protective effects upon the in...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164101101198343
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVES:To review the use of immunoassays in the diagnosis and research of disorders affecting the nervous system. METHODS:Systematic review of the English literature. RESULTS:Immunoassays have demonstrated utility for: (1) the detection of antigen (molecules, genes, gene products, peptides, hormones and drug meta...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164105X49535
更新日期:2005-10-01 00:00:00
abstract:INTRODUCTION:Numerous studies have demonstrated a protective effect of hyperbaric oxygen therapy in experimental ischemic brain injury, and many physiological and molecular mechanisms of hyperbaric oxygen therapy-related neuroprotection have been identified. METHODS:Review of articles pertaining to hyperbaric oxygen t...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/174313209X389857
更新日期:2009-03-01 00:00:00
abstract::To investigate the migration of neural stem cells as well as neural plastic changes in epileptic brain, spaciotemporal expression of immunoreactive highly polysialylated neural cell adhesion molecule (PSA-NCAM) was examined in amygdala kindling development of rat. The neural migration and synaptic remodeling detected ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101200969
更新日期:2003-01-01 00:00:00