Horizontal cell dynamics: what are the main factors?

Abstract:

:The factors potentially determining the dynamics of horizontal cell (HC) responses are: (1) the rate of transmitter release (including its transient component) and removal; (2) the voltage non-linearity of HC non-synaptic membrane combined with its capacitance; and (3) the dynamics of feedback from HCs to photoreceptors. Using, in consecutive order, the models of an isolated HC, a HC with one or two synaptic inputs and a HC of chromatic type, we have analysed the relative importance of three factors in shaping HC responses to the light and electrical current. The most prominent effect on the shape of HC ON responses derives from the voltage-dependency of the non-synaptic membrane. The dynamics of synaptic transmission plays a leading role in shaping the OFF light responses. For depolarizing responses of C-type HCs, the key factor is the electrical feedback from L-type HCs, which provides not only the response of opposite polarity (to red light), but also the typical feedback delay.

journal_name

Vision Res

journal_title

Vision research

authors

Maximov VV,Byzov AL

doi

10.1016/s0042-6989(96)00130-7

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

4077-87

issue

24

eissn

0042-6989

issn

1878-5646

pii

S0042-6989(96)00130-7

journal_volume

36

pub_type

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