Continued neurogenesis is not a pre-requisite for regeneration of a topographic retino-tectal projection.

Abstract:

:Electrophysiological recording demonstrated that visuo-tectal projections are topographically organised after optic nerve regeneration in aged Xenopus laevis. 3H-thymidine autoradiography confirmed previous reports [Taylor, Lack, & Easter, Eur. Journal of Neuroscience 1 (1989) 626-638] that cell division had already ceased at the retinal ciliary margin. The results demonstrate that, contrary to a previous suggestion [Holder & Clarke, Trends in Neuroscience 11 (1988) 94-99], continued neurogenesis is not a pre-requisite for the re-establishment of appropriate connections with target cells.

journal_name

Vision Res

journal_title

Vision research

authors

Beaver RS,Dunlop SA,Harman AM,Stirling RV,Easter SS,Roberts JD,Beazley LD

doi

10.1016/s0042-6989(01)00053-0

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

1765-70

issue

14

eissn

0042-6989

issn

1878-5646

pii

S0042-6989(01)00053-0

journal_volume

41

pub_type

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