Abstract：
:As impaired S-cone function has been reported psychophysically this study assessed S-cone function during high altitude exposure using electroretinography (ERG) and investigated a possible association with severity of acute mountain sickness (AMS). This work is related to the Tübingen High Altitude Ophthalmology (THAO) study. Standard ERG equipment was used (Diagnosys LLC, Cambridge, UK) with special protocol settings to extract S-cone function. Twelve subjects were analyzed in the current study and examinations were performed in Tübingen, Germany (341m) as baseline and thereafter at the Capanna Margherita, Italy (4559m) at high altitude. Results were compared using a paired t-test. Correlations between ERG measurements and oxygen saturation (SpO2), heart rate (HR) and scores of acute mountain sickness (AMS-C and LL) were calculated using Pearson's correlation coefficients. Amplitudes of S-cone b-waves decreased significantly at high altitude (p=0.02). No significant changes were observed for implicit times of b-waves (p=0.63), a-waves (p=0.75) or for a-wave amplitudes (p=0.78). The incidence of AMS was 50% at high altitude according to AMS-C and LL scores (AMS-C⩾0.7 and LL⩾5). Heart rate increased to 84±10min(-1) and SpO2 decreased to 71.9±5.7% at high altitude. No significant correlation was found between S-cone ERG parameters and SpO2, HR, AMS-C and LL. For the first time our study defines a significant impairment of S-cone function at high altitude time using objective state of the art examination methods. No correlation between the functional impairment of S-cones and levels of AMS was detected.
journal_name
Vision Resjournal_title
Vision researchauthors
Schatz A,Dominik Fischer M,Schommer K,Zrenner E,Bartz-Schmidt KU,Gekeler F,Willmann Gdoi
10.1016/j.visres.2014.02.003subject
Has Abstractpub_date
2014-04-01 00:00:00pages
59-64eissn
0042-6989issn
1878-5646pii
S0042-6989(14)00030-3journal_volume
97pub_type
杂志文章相关文献
VISION RESEARCH文献大全abstract：:Microspectrophotometry (MSP) shows rhodopsin highly concentrated (about 3.0 mmol/l) in rod outer segments (ROS). Calculation of the in vivo absorption spectrum of human rhodopsin from such data reveals a striking failure to agree with the action spectrum of human rod vision. Agreement is good between the spectral dist...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(87)90155-6
更新日期：1987-01-01 00:00:00
abstract：:The present study provides new clues about visual processes underlying the human pupillary responses evoked by achromatic spatial patterns. The pupillary responses can be modeled as a combination of two processes, a temporally transient process which saturates with increasing contrast and a temporally sustained proces...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(93)90103-4
更新日期：1993-11-01 00:00:00
abstract：:Over the past years, knowledge has expanded with regards to the multiple roles played by erythropoietin (EPO) in the body. Once believed to be a hormone synthesised in the kidney and involved only in the modulation of erythrocyte production, it is recognised now that EPO can be produced in many tissues, including the ...
journal_title：Vision research
pub_type： 杂志文章,评审
doi：10.1016/j.visres.2017.05.010
更新日期：2017-10-01 00:00:00
abstract：:The spatial extent of interference from nearby object or contours (the critical spacing of "crowding") has been thoroughly characterized across the visual field, typically using high contrast achromatic stimuli. However, attempts to link this measure with known properties of physiological pathways have been inconclusi...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2016.03.007
更新日期：2016-05-01 00:00:00
abstract：:We measured increment thresholds up to 5 degrees eccentricity using a 10' dia flash viewed against 10(4) td of 572-nm background. We found two distinct sensitivity profiles, one with flash wavelengths 410-470 nm and another with 520-580 nm. Spectral sensitivity plots indicate blue-sensitive cones and green-sensitive c...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(82)90102-x
更新日期：1982-01-01 00:00:00
abstract：:Subjects made smooth pursuit eye movements with a target moving horizontally at 15 deg/sec. At a specified location the target either: (1) suddenly vanished; or (2) jumped to the fovea with target retinal velocity and feedback becoming 0 (target stabilized at the fovea). In each type of trial, the subjects either: "lo...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(97)00058-8
更新日期：1997-09-01 00:00:00
abstract：:Induced motion, the apparent motion of an object when a nearby object moves, has been shown to occur in a variety of different conditions, including motion in depth. Here we explore whether similar patterns of induced motion result from induction in a lateral direction (frontoparallel motion) or induction in depth. We...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2007.11.018
更新日期：2008-02-01 00:00:00
abstract：:In previous work, subjects looked at a target stabilized at the fovea, superimposed on a sinusiodally moving OKN stimulus. The stabilized target (no retinal-slip) suppressed OKN leaving residual eye movements that were often in counterphase with the OKN stimulus motion. In the present study we explored how this type o...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(95)00062-5
更新日期：1995-10-01 00:00:00
abstract：:A considerable body of evidence suggests the existence of a two-stage mechanism for the detection of global motion. In the first stage the motion of elongated contours is extracted and then at the second stage these one-dimensional (1D) motion signals are combined. What is the nature of the computation carried out in ...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(93)90045-x
更新日期：1993-07-01 00:00:00
abstract：:Several studies have shown that the perceived position of a briefly presented stimulus can be displaced by nearby motion or by eye movements. We examined whether attentive tracking can also modulate the perceived position of flashed static objects when eye movements and low-level motion are controlled. Observers atten...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2005.05.029
更新日期：2005-11-01 00:00:00
abstract：:Gratings that differ in orientation by as much as 62.5 deg from that of a signal grating raise the signal's threshold by nearly a log unit. The spatial-frequency tuning of the masking effect reaches a maximum slightly below the spatial frequency of the maskers but far from that of any quadratic distortion product. Fur...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(89)90127-2
更新日期：1989-01-01 00:00:00
abstract：:Visual information is an essential guide when interacting with moving objects, yet it can also be deceiving. For instance, motion can induce illusory position shifts, such that a moving ball can seem to have bounced past its true point of contact with the ground. Some evidence suggests illusory motion-induced position...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2012.03.010
更新日期：2012-05-01 00:00:00
abstract：:The contrast matching function (CMF) is the reciprocal of test contrast that perceptually matches the contrast of standard pattern, measured as a function of test spatial frequency (SF). Achromatic CMFs usually flatten as the contrast of the standard is raised, and are broader than the achromatic, bandpass, contrast s...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(00)00171-1
更新日期：2000-01-01 00:00:00
abstract：:Though the human eye generally creates a single image on the retina, the literature contains many examples showing perceptual monocular diplopia. Previously, monocular diplopia resulting from astigmatic defocus has been demonstrated to cause a notch (local minimum) in the contrast sensitivity function (CSF). We examin...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(96)00091-0
更新日期：1996-11-01 00:00:00
abstract：:Visual search for a colour target in distractors of two other colours is dramatically affected by the configuration of the colours in CIE (x, y) space. To a first approximation, search is difficult when a target's chromaticity falls directly between (i.e. is not linearly separable from) two distractor chromaticities, ...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(98)00302-2
更新日期：1999-08-01 00:00:00
abstract：:We examined the ability of observers to determine the vertical alignment of three Gabor patches (cosine gratings tapered in X and Y by Gaussians) when the grating within the middle patch was moving right or left. The comparison patches were flickered in counterphase, as was the test patch in a control condition. In al...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(91)90138-u
更新日期：1991-01-01 00:00:00
abstract：:We designed two extensions of Saslow's well-known gap and overlap conditions that require increased voluntary effort because of the progressive elimination of target onsets and fixation point offsets, and obtained repeatable data obeying simple numerical relations. For each of the five stimulus lighting conditions, sa...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(01)00295-4
更新日期：2002-03-01 00:00:00
abstract：:Using displacing prisms to dissociate the influence of optic flow and egocentric direction, previous research (Current Biology 8 (1998) 1191) showed that people primarily use egocentric direction to control their locomotion on foot, rather than optic flow. When wearing displacing prisms, participants followed the curv...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(02)00066-4
更新日期：2002-06-01 00:00:00
abstract：:The factors potentially determining the dynamics of horizontal cell (HC) responses are: (1) the rate of transmitter release (including its transient component) and removal; (2) the voltage non-linearity of HC non-synaptic membrane combined with its capacitance; and (3) the dynamics of feedback from HCs to photorecepto...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(96)00130-7
更新日期：1996-12-01 00:00:00
abstract：:It is possible to discriminate between grating contrasts over a 300-fold contrast range, whereas V1 neurons have very limited dynamic ranges. Using populations of model neurons with contrast-response parameters taken from electrophysiological studies (cat and macaque), we investigated ways of combining responses to co...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(03)00277-3
更新日期：2003-08-01 00:00:00
abstract：:We have tested whether defocus imposed on local retinal areas can produce local changes in eye growth, even if accommodation is available to clear part of the imposed defocus. Hemi-field lenses were attached to little leather hoods that were worn by young chickens from day 11-15 post-hatching. The lens segments defocu...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(96)00224-6
更新日期：1997-03-01 00:00:00
abstract：:Color samples selected from the OSA Uniform Color Scales set were seen isolated in a dark field, illuminated by hidden projectors. These appeared as self-luminous aperture colors when thus isolated. We employed a categorical color-naming procedure to assess color appearance. Achromatic surrounds of 33 min width, if ad...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(89)90099-0
更新日期：1989-01-01 00:00:00
abstract：:Patients with central vision loss are often advised by low vision rehabilitation professionals to read bolder print to ameliorate their reading difficulties. Is boldface print really effective in improving reading performance for people with central vision loss? In this study, we evaluated how reading speed depends on...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2018.10.012
更新日期：2018-12-01 00:00:00
abstract：:To examine how local velocities from different regions of the visual field combine to form a coherent motion percept, we subjected a sinusoidal line stimulus to translational motion. Horizontal movement of a sinewave line along its axial direction is perceived as nonrigid if the angle at the zero crossing is smaller t...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(88)90052-1
更新日期：1988-01-01 00:00:00
abstract：:We made a comprehensive study, involving observations on 45 marmosets, of the effects on ocular growth and refraction of wearing spectacles from the ages of 4-8 weeks. This period was within the period early in life when the eye grows rapidly and refraction changes from hyperopia to its adult value of modest myopia. I...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(98)00189-8
更新日期：1999-01-01 00:00:00
abstract：:When a visual stimulus is displaced during a saccade the displacement is often not noticed unless it is large compared to the amplitude of the eye movement. Displacement detection is improved, however, if a blank intervenes between saccade target offset and the presentation of the displaced post-saccadic stimulus. Thi...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2017.09.004
更新日期：2018-01-01 00:00:00
abstract：:Reaction times for detecting sinusoidal gratings depend jointly on grating contrast and spatial frequency. We examine whether the effect of spatial frequency results from low-pass filtering in a single channel or reflects processing of different frequencies by two or more different processing streams. Observers perfor...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(98)00193-x
更新日期：1999-05-01 00:00:00
abstract：:Increment thresholds were measured over a range of adapting illuminances using a modified automated static perimeter. The data were fitted to a threshold versus intensity model (logT - logT(0) + log((A + A(0))/A(0))n) and the values logT(0) and logA(0) estimated. The effect of eccentricity and age on logT(0) and logA(...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2004.09.008
更新日期：2005-02-01 00:00:00
abstract：:Perceptual constancy refers to the ability to stabilize the representation of an object even though the retinal image of the object undergoes variations. In previous studies, we proposed a General Object Constancy (GOC) hypothesis to demonstrate a common stabilization mechanism for perception of an object's features, ...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2016.09.015
更新日期：2016-12-01 00:00:00
abstract：:Perceived contrast, contrast detection thresholds and contrast discrimination thresholds were measured in the presence and absence of surrounding patterns of a similar spatio-temporal makeup. In the foveal retina we found that the perceived contrast of the central pattern was reduced by the presence of the contrast su...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(97)00379-9
更新日期：1998-06-01 00:00:00
