Abstract：
:Genetic analyses were performed on five male children (approximately 3 years), two suspect color-normals and three suspects for congenital color vision deficiencies. These classifications were based on visually-evoked potential (VEP) responses to M- and L-cone-isolating stimuli obtained in a previous study when each subject was either 4- or 8-weeks old. The present analyses were performed in a blind study to characterize the genotypes of these subjects. Four male adults with various color vision phenotypes were also tested as a control. DNA was isolated using a non-invasive technique followed by polymerase chain reaction (PCR) amplification and restriction enzyme analysis to examine the genomic DNA of each subject. The genetic analyses confirmed the VEP identification of two color defective infants, and were consistent with the diagnosis of two other infants as color normal. A third infant was predicted by VEP analysis to have a protan defect, but he did not have a gene array typically found in protan observers.
journal_name
Vision Resjournal_title
Vision researchauthors
Bieber ML,Werner JS,Knoblauch K,Neitz J,Neitz Mdoi
10.1016/s0042-6989(98)00067-4subject
Has Abstractpub_date
1998-11-01 00:00:00pages
3293-7issue
21eissn
0042-6989issn
1878-5646pii
S0042-6989(98)00067-4journal_volume
38pub_type
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