Abstract：
:A dominant mechanism of cellular patterning in the growing fish retina is control of cell fate acquisition by negative feedback signals arising from differentiated cells. We tested the ability of a computational model of this pattern formation mechanism to simulate cellular patterns in regenerated goldfish retina. The model successfully simulated quantitative features of in vivo regenerated patterns, indicating that regenerating retina has access to and utilizes patterning mechanisms that are operational during normal growth. The atypical patterns of regenerated retina could arise in part from regenerative progenitors that, compared to normal growth progenitors, are less responsive to the feedback patterning signals.
journal_name
Vision Resjournal_title
Vision researchauthors
Tyler MJ,Cameron DAdoi
10.1016/j.visres.2006.08.025subject
Has Abstractpub_date
2007-02-01 00:00:00pages
501-11issue
4eissn
0042-6989issn
1878-5646pii
S0042-6989(06)00392-0journal_volume
47pub_type
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