Identification of novel retinal target genes of thyroid hormone in the human WERI cells by expression microarray analysis.

Abstract:

:Using the human WERI-Rb1 cell line as a model system, we performed a genome-wide search for retinal target genes of thyroid hormone (TH) via expression microarray analysis followed by quantitative real-time RT-PCR verification. We identified 12 novel retinal targets of TH, including 10 up-regulated genes (OPN1MW, OPN1LW, TIMP3, RP1L1, GNGT2, CRX, ARR3, GCAP1, IMPDH1, and PDE6C) and 2 down-regulated genes (GNGT1 and GNB3). In addition, we found a number of novel TH-targets that are not currently known to be retinal genes. This is the first report of human retinal targets regulated by thyroid hormone.

journal_name

Vision Res

journal_title

Vision research

authors

Liu Y,Fu L,Chen DG,Deeb SS

doi

10.1016/j.visres.2007.04.023

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

2314-26

issue

17

eissn

0042-6989

issn

1878-5646

pii

S0042-6989(07)00189-7

journal_volume

47

pub_type

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