Abstract:
:Using the human WERI-Rb1 cell line as a model system, we performed a genome-wide search for retinal target genes of thyroid hormone (TH) via expression microarray analysis followed by quantitative real-time RT-PCR verification. We identified 12 novel retinal targets of TH, including 10 up-regulated genes (OPN1MW, OPN1LW, TIMP3, RP1L1, GNGT2, CRX, ARR3, GCAP1, IMPDH1, and PDE6C) and 2 down-regulated genes (GNGT1 and GNB3). In addition, we found a number of novel TH-targets that are not currently known to be retinal genes. This is the first report of human retinal targets regulated by thyroid hormone.
journal_name
Vision Resjournal_title
Vision researchauthors
Liu Y,Fu L,Chen DG,Deeb SSdoi
10.1016/j.visres.2007.04.023subject
Has Abstractpub_date
2007-08-01 00:00:00pages
2314-26issue
17eissn
0042-6989issn
1878-5646pii
S0042-6989(07)00189-7journal_volume
47pub_type
杂志文章相关文献
VISION RESEARCH文献大全abstract::Previous studies have shown that spatial context influences the perceptual interpretation of ambiguous figures such as the Necker cube; however, the properties that mediate the influences of an unambiguous spatial context have yet to be investigated. Here we consider the effect of the motion and position of an unambig...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2016.02.005
更新日期:2016-09-01 00:00:00
abstract::We examined the ability of human observers to detect three kinds of statistical structure in binary arrays: first-order statistics (luminance), local fourth-order statistics (isodipole textures), and long-range statistics (bilateral symmetry). Performance was closest to ideal on the luminance task and furthest from id...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2004.10.012
更新日期:2005-04-01 00:00:00
abstract::Detailed measurements of saccadic latency--the time taken to make an eye movement to a suddenly-presented visual target--have proved a valuable source of detailed and quantitative information in a wide range of neurological conditions, as well as shedding light on the mechanisms of decision, currently of intense inter...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2013.02.007
更新日期:2013-05-24 00:00:00
abstract::A major factor underlying the prolonged postnatal improvement of visual acuity in primates is an increase in the sampling limit imposed by the photoreceptor mosaic, which may be as much as 5-fold. Further factors operating peripheral to neurons of the lateral geniculate nucleus, which might include changes in neural c...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(88)90104-6
更新日期:1988-01-01 00:00:00
abstract::The Bezold-Brücke phenomenon was measured during the cone-plateau period of the long-term dark-adaptation curve at 25 degrees, 40 degrees and 60 degrees in the nasal field of view, and at 40 degrees and 70 degrees in the temporal field. In striking contrast to previous measurements of the B-B phenomenon the present re...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(82)90018-9
更新日期:1982-01-01 00:00:00
abstract::Growth and decay characteristics of the tilt aftereffect were studied for aftereffects induced by normal or continuous adaptation routines, and for aftereffects induced by successive or spaced adaptation to the same or different orientations on an adapt-partial decay-readapt schedule. In the continuous adaptation cond...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(86)90014-3
更新日期:1986-01-01 00:00:00
abstract::Loss of photoreceptors during retinal degeneration leads to blindness, but information can be reintroduced into the visual system using electrical stimulation of the remaining retinal neurons. Subretinal photovoltaic arrays convert pulsed illumination into pulsed electric current to stimulate the inner retinal neurons...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2014.09.007
更新日期:2015-06-01 00:00:00
abstract::We report a series of nine experiments which show that a single roll-tilted line in darkness induces changes of the orientation perceived as vertical (VPV) that are similar in magnitude and direction to those measured by Witkin and Asch (1948a) [Studies in space orientation. I. Perception of the upright with displaced...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2005.01.014
更新日期:2005-07-01 00:00:00
abstract::It is known that SPARC gates VEGF-A signal transduction towards KDR, the primary angiogenic VEGF receptor. We sought to determine whether inhibition of SPARC activity using anti-SPARC peptide could inhibit laser-induced CNV by promoting binding of VEGF-A to FLT-1. We created anti-SPARC l-peptide and retro-inverso anti...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2009.12.003
更新日期:2010-03-31 00:00:00
abstract::Three experiments of visual search for a cube (for a square pillar in Experiment 3) with an odd conjunction of orientation of faces and color (a cube with a red top face and a green right face among cubes with a green top face and a red right face, for example) showed that the search is made more efficient by arrangin...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(03)00300-6
更新日期:2003-08-01 00:00:00
abstract::A considerable body of evidence suggests the existence of a two-stage mechanism for the detection of global motion. In the first stage the motion of elongated contours is extracted and then at the second stage these one-dimensional (1D) motion signals are combined. What is the nature of the computation carried out in ...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(93)90045-x
更新日期:1993-07-01 00:00:00
abstract::The spectral sensitivity of the extracellularly-recorded photoresponse of isolated rods of the tiger salamander, Ambystoma tigrinum, was compared to the absorptance spectrum. Both measurements were made with the same optical system on the same portion of each cell to avoid errors that could occur when the two kinds of...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(84)90323-7
更新日期:1984-01-01 00:00:00
abstract::The effects of the involuntary ocular oscillations on visual resolution was examined in 22 albinos and 11 idiopaths with congenital nystagmus. The idiopaths showed a linear relationship between the proportion of the slow phase spent at low velocities (less than or equal to deg/sec) and the log of the minimum angle of ...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(91)90063-b
更新日期:1991-01-01 00:00:00
abstract::Increment-threshold spectral sensitivity functions were taken foveally and at four other retinal locations with different sized test stimuli. For the fovea and parafovea at 4 degrees, a 1 degree, 250 msec stimulus of variable wavelength, flashed on a 1000 td white background yielded spectral sensitivity curves with th...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(82)90142-0
更新日期:1982-01-01 00:00:00
abstract::Psychophysical studies of interactions between contours defined by different image attributes report that luminance-defined and illusory contours show little if any interaction. Because the contours defined by these attributes may vary in perceptual saliency, we employed the tilt aftereffect (TAE) and a cross-adaptati...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(94)90333-6
更新日期:1994-01-01 00:00:00
abstract::Some blind humans use sound to navigate by emitting mouth-clicks and listening to the echoes that reflect from silent objects and surfaces in their surroundings. These echoes contain information about the size, shape, location, and material properties of objects. Here we present results from an fMRI experiment that in...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2014.07.004
更新日期:2015-04-01 00:00:00
abstract::Two experiments investigated modulatory effects of a surround upon the perceived speed of a moving central region. Both the surround's depth and velocity (relative to the center) were manipulated. The abilities of younger observers (mean age was 23.1 years) were evaluated in Experiment 1, while Experiment 2 was devote...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2009.10.009
更新日期:2010-01-01 00:00:00
abstract::Existing models for the generation of saccades predict fixed trajectories between start and landing positions of saccades. Experimental data show that saccades have rather variable trajectories. The objective of the present research is to quantify the variability in trajectories of binocular saccades and to test in ho...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(95)00077-r
更新日期:1995-12-01 00:00:00
abstract::Smooth pursuit eye movements superimpose additional motion on the retinal image of untracked visual targets, potentially leading to the perception of motion smear and a distortion of the perceived direction of motion. Previously, we demonstrated an attenuation of perceived motion smear when the untracked target moves ...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2006.12.002
更新日期:2007-03-01 00:00:00
abstract::The study examines age-dependent changes of kynurenic acid (KYNA) content and kynurenine aminotransferases (KAT I and KAT II) celluar expression in the retinas of DBA/2J mice. Retinas were obtained from DBA/2J mice of different ages (3, 6 and 11 months). C57BL6 mice were used as controls. As measured with HPLC, KYNA c...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2003.11.003
更新日期:2004-03-01 00:00:00
abstract::Jumping spiders (Salticidae) are renowned for their high performing visual system. In addition to their prominent forward-facing telescope-like principal eyes, salticids possess two or three pairs of secondary eyes used for wide-angle motion detection. Salticids orient towards relevant sources of motion detected by th...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2012.06.011
更新日期:2012-08-01 00:00:00
abstract::Adaptation is a fundamental property of perceptual processing. In low-level vision, it can calibrate perception to current inputs, increasing coding efficiency and enhancing discrimination around the adapted level. Adaptation also occurs in high-level vision, as illustrated by face aftereffects. However, the functiona...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2010.03.003
更新日期:2010-05-12 00:00:00
abstract::From the earliest stages of sensory processing, neurons show inherent non-linearities: the response to a complex stimulus is not a sum of the responses to a set of constituent basis stimuli. These non-linearities come in a number of forms and have been explained in terms of a number of functional goals. The family of ...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2015.10.015
更新日期:2016-03-01 00:00:00
abstract::Electroretinographic responses (ERGs) have been recorded from the cornea of the little owl (Athene noctua) in response to single light flashes and to alternating sinusoidal gratings (pattern) at different levels of light adaptation. Both flash- and pattern-evoked ERGs show scotopic as well as photopic components. The ...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(89)90151-x
更新日期:1989-01-01 00:00:00
abstract::The purpose of this study was to investigate the roles of the putative "spatial filter" and "local sign" mechanisms in determining line vernier thresholds for a range of target separations, using stimulus contrast or visibility as a tool. In Expt 1, the effects of varying target contrast and exposure duration on verni...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(93)90257-w
更新日期:1993-03-01 00:00:00
abstract::The visual pigments in the rods do not have a special absorption that gives them maximal sensitivity. The visual pigments of "deep sea" fish are an exception for these do match the environmental light to give maximum sensitivity. At the low light intensities at which the rods operate, it is the number of photons that ...
journal_title:Vision research
pub_type: 杂志文章,评审
doi:10.1016/s0042-6989(84)80003-6
更新日期:1984-01-01 00:00:00
abstract::Face exposure during development determines adults' abilities to recognize faces and the information they use to process them. Individual differences in the face categories represented in the visual environment can lead to category-specific deficits for recognizing faces that are atypical of observer's experience (e.g...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2016.12.005
更新日期:2017-12-01 00:00:00
abstract::Thresholds for detecting the angle of rotation of vertical symmetrical patterns containing few or no explicit vertical or horizontal contours were found to be almost as low as those for an actual vertical line extending approximately the same range. This hyperacuity performance, which we refer to as implicit orientati...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(96)00166-6
更新日期:1997-03-01 00:00:00
abstract::Flickering lights can be uncomfortable to look at and can induce seizures in observers with photosensitive epilepsy. However, the temporal characteristics contributing to these effects are not fully known. In the spatial domain, one identified source of visual discomfort is when images have Fourier amplitude spectra t...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2017.05.015
更新日期:2017-09-01 00:00:00
abstract::A panel of anti-bovine rhodopsin monoclonal antibodies (MAbs) of defined site-specificity has been prepared and used for functional and topographic studies of rhodopsins. In order to select these antibodies, hybridoma supernatants that contained anti-rhodopsin antibodies have been screened by enzyme-linked immunosorbe...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(91)90069-h
更新日期:1991-01-01 00:00:00