[Chronic granulomatous disease (CGD): dysfunction of the neutrophil granulocyte NADPH-oxidase enzyme system].

Abstract:

:Dysfunction of NADPH oxidase results in chronic granulomatous disease (CGD), a syndrome characterized by severe bacterial and fungal infections. Phagocytes of the patients are unable to kill ingested microorganisms which leads to the formation of granulomas and abscesses. Predominant pathogens are the catalase-positive bacteriae (Staphylococcus aureus) and some fungi (Aspergillus species). Infections of these patients should be treated by antimicrobial agents, which penetrate cells and kill pathogens inside. The aim of this study was to give a short description of the structure and function of the NADPH oxidase enzyme and to summarize the results obtained during the diagnostic of 10 patients with chronic granulomatous disease. Characterization of the disease was confirmed by mutation analyses.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Német K,Fekete G,Schuler D,Kiss E,Mészner Z,Kriván G,Kardos G,Galántai I,Póder G,Kalmár A,de Boer M,Roos D

subject

Has Abstract

pub_date

1997-02-16 00:00:00

pages

397-401

issue

7

eissn

0030-6002

issn

1788-6120

journal_volume

138

pub_type

杂志文章,评审
  • [Colorectal cancer heterogeneity: the clinical impact of sporadic lesions arising via the serrated pathway].

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  • [Selection of statin considering the HDL cholesterol level].

    abstract::Low HDL cholesterol level is an independent risk factor in the cardivascular diseases and the therapeutic aim is to increase this. In high risk patients (cardiovascular disease-, diabetic- or metabolic syndrome patients), the target value of HDL cholesterol is more than 1,0 mmol/l in males and 1,3 mmol/l in females. T...

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    doi:

    authors: Kalina A

    更新日期:2006-11-26 00:00:00

  • [Eosinophilic gastroenteritis].

    abstract::A case of a young man with eosinophilic gastroenteritis with mucosal involvement in the antrum and duodenum is presented. The diagnosis was based on endoscopic biopsy with histological examination, peripheral blood eosinophilia and gastrointestinal symptoms, like abdominal cramping, nausea, vomiting and diarrhoea. Par...

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    doi:

    authors: Nagy P,Taller A,Iliás L

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  • [The role of environmental factors in managing labour stress].

    abstract:INTRODUCTION:Emotional, cognitive and behavioural aspects of birth and labour stress are strongly associated with the underlying physiological processes. AIM:To study the factors of physical security and social support, the administration of synthetic oxytocin, and how they relate to perceived stress during childbirth...

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    doi:10.1556/650.2017.30797

    authors: Rados M,Mészáros J

    更新日期:2017-07-01 00:00:00

  • Up-to-date management of acute traumatic bleeding and coagulopathy

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    authors: Szentkereszty Z

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  • [Effect of paracetamol on the acid hemolysis of erythrocytes, with special reference to the intracellular glutathione level].

    abstract::The authors give account of their study concerning the effect of paracetamol on the acid haemolysis, and glutathione content of human erythrocytes. In vitro, paracetamol decreased intracellular glutathione content in a dose dependent manner. This may lead to an increased sensitivity of erythrocytes to the haemolytic e...

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    pub_type: 杂志文章

    doi:

    authors: Altorjay I,Sári B,Imre S,Balla G,Dalmi L

    更新日期:1993-10-10 00:00:00

  • [Image-guided radiotherapy for muscle invasive bladder cancer with intravesical lipiodol injection. A new option for bladder sparing treatment].

    abstract:INTRODUCTION AND AIM:To implement lipiodol as a fiducial marker of the tumor bed for image-guided radiotherapy with simultaneous integrated boost technique as part of radiochemotherapy for muscle invasive bladder tumors. METHOD:Since April 2016, radiochemotherapy was performed in 3 male patients with muscle invasive, ...

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    pub_type: 杂志文章

    doi:10.1556/650.2017.30904

    authors: Kliton J,Polgár C,Tenke P,Kovács G,Major T,Stelczer G,Ágoston P

    更新日期:2017-12-01 00:00:00

  • [Vulvar melanosis and vitiligo].

    abstract::Clinically it is impossible to make difference between the vulvar melanosis the harmless brown spotty change of the vulva and melanoma malignum, that is one of the most dangerous malignancies. Even the dermatoscopical examination was not efficient to exclude the melanoma surely. A small, representative biopsy was enou...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Haraszti G,Kemény L,Bónis B,Dobozi A

    更新日期:1998-04-05 00:00:00

  • [Hashimoto encephalopathy].

    abstract::The authors present a case report and review the literature on Hashimoto encephalopathy. The onset of the disease may be marked by focal and then progressively generalized seizures or other neurological symptoms, but a cognitive decline or various psychiatric symptoms may also emerge. High levels of anti-thyroid perox...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2013.29684

    authors: Pocsay G,Gazdag A,Engelhardt J,Szaniszló I,Szolnoki Z,Forczek G,Mikló L

    更新日期:2013-08-18 00:00:00

  • [The measureable clinical signs of malnutrition: the clinical significance of body composition - bioimpedance - analysis].

    abstract::Undernutrition, or more precisely: malnutrition results in worse outcome in clinical practice. Recognition and treatment of different forms of malnutrition are not unconditionally easy in the daily routine, however, it could lead to significant improvement in the outcome. This review summarizes the most frequent forms...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2014.30050

    authors: Török É,Harsányi L

    更新日期:2014-12-21 00:00:00

  • [Regulation of blood circulation].

    abstract::This study gives an outline of the regulation of the circulation. After describing the possible regulatory effects on the main functional units of the cardiovascular system, namely on the heart as a hemodynamic pump, on the tubing of the vascular system, and on the microcirculation, it makes a general survey of the ne...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Angyán L

    更新日期:1991-04-30 00:00:00

  • [Initial experience with ultrasonic examination of the rectum].

    abstract::The authors report their initial results obtained by the use of transrectal sonography in examination of known or suspected rectal and perirectal masses. 42 patients were examined with commercially available endosonographic probes. 22 patients had known rectal cancer. 13 patients underwent surgical exploration. Malign...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Jakab Z,Görög D,Papp J,Lestár B

    更新日期:1991-12-30 00:00:00

  • [Multiorgan manifestations in myotonic dystrophy type 1].

    abstract::Myotonic dystrophy is one of the most common, autosomal dominantly inherited adult-onset muscle disorders. Two types of the disease are known: type 1 is characterized by distal weakness and myotonia, but type 2 is associated with proximal weakness and milder clinical course. It is also called as Steinert Disease, whic...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2019.31505

    authors: Varga D,Pál E

    更新日期:2019-09-01 00:00:00

  • [Novel treatment modalities in cutaneous T cell lymphoma. Biologic response modifiers].

    abstract::Biologic response modifiers. Biologic response modifiers such as IFN-alpha, retinoids and extracorporeal photopheresis have been widely used in the treatment of cutaneous lymphoma. The novel treatment modalities like cytokine therapies, monoclonal antibodies and fusion proteins have been used only in limited number of...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Marschalkó M

    更新日期:2005-06-05 00:00:00

  • [New diagnostic possibilities in dermatologic diseases].

    abstract::The author reviews the latest developments regarding the most important immunological methods for the diagnosis of dermatological diseases. The salt-split-skin, fluorescence overlay antigen mapping and immunoblot techniques are useful methods for the differentiation of autoimmune bullous skin diseases. The use of reco...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Husz S

    更新日期:1999-09-26 00:00:00

  • [Clinical experiences with the analgesic effects of citalopram].

    abstract::Antidepressive drugs influencing the serotonin metabolism have shown some efficacy in treatment of generalised pain syndrome. The aim of the present study was to observe the analgesic effect of citalopram < 1-[3-(dimetilamino)propil]-1-(p-florofenil)-5-ftal+ ++ánkarbonitin > in 20 non depressive patients with chronic...

    journal_title:Orvosi hetilap

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Baraczka K,Jankó Z,Vargha K,Márkus H

    更新日期:1997-10-12 00:00:00

  • [Interobserver reproducibility of Gleason grading in prostate biopsy samples].

    abstract:INTRODUCTION:Gleason grading is the most common method of prostate cancer classification. AIM:The aim of the authors was to assess the reproducibility of Gleason grading among pathologists using the same needle biopsy samples. METHOD:23 pathologists examined 37 prostate cancer biopsies stained with hematoxylin and eo...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2013.29659

    authors: Bori R,Salamon F,Móczár C,Cserni G

    更新日期:2013-08-04 00:00:00

  • [Lymphangiomyoma of the thoracic duct].

    abstract::From the right superior mediastinum of a 31-year old woman the authors extirpated a lymphangiomyoma originating from the thoracic duct. The clinical feature and pathology of this rare lesions are discussed. This case is the first successfully removed thoracic duct lymphangiomyoma in Hungary. ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Pommersheim F,Szerján E,Besznyák I,Csiszér E

    更新日期:1993-09-12 00:00:00

  • [Current pharmacotherapy of Parkinson's disease].

    abstract::Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The morbidity is about 1-2 of 1000 under 65 years, but it increases to 1-2 of 100 in the population over 65 years. PD became the model of degenerative disorders either concerning the etiopathogenesis or the therapeutic possibilities. Recen...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Takáts A

    更新日期:2000-03-05 00:00:00

  • Extracorporeal irradiation: biological reconstruction following tumor resection with a large bone defect

    abstract::Összefoglaló. A malignus csonttumorok sebészi ellátása során kialakuló szegmentális csontdefektusok pótlása fontos szempont a végtagmegtartó sebészetben. Felnőttkorban a megoldás rendszerint tumorprotézis beültetése, 10 évesnél fiatalabb gyermekeknél azonban ez nehezen alkalmazható módszer a kis csontméret és az igen ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2020.31767

    authors: Perlaky T,Kiss J,Szalay K,Maysam MA,Ágoston P,Szendrői M

    更新日期:2020-11-08 00:00:00

  • [Changes in the innervation of the taste buds in diabetic rats].

    abstract:INTRODUCTION:Abnormal sensations such as pain and impairment of taste are symptoms of approximately 10% of patients having diabetes mellitus. AIM:The aim of the study was to investigate and quantify the different neuropeptide containing nerve fibres in the vallate papilla of the diabetic rat. METHODS:Immunohistochemi...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2013.29570

    authors: Hevér H,Altdorfer K,Zelles T,Batbayar B,Fehér E

    更新日期:2013-03-24 00:00:00

  • [Evaluation of survival in mixed connective tissue disease (MCTD)].

    abstract:INTRODUCTION:179 patients with mixed connective tissue disease (MCTD) were follow-up, and the cause of death was analyzed in 12 died patients. PATIENTS AND METHODS:The survival of 179 patients with MCTD was evaluated by using Kaplan-Meier's method. Clinically and immunological data of the patients were analyzed betwee...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Bodolay E,Gaál J,Végh J,Soltész P,Szodoray P,Lakos G,Nemes Z,Dezsö B,Szegedi G

    更新日期:2002-11-10 00:00:00

  • [The level of use of statistical data in articles in the Orvosi Hetilap].

    abstract::The objective was to assess the level of use of statistics in the articles of the Orvosi Hetilap (OH). Eight clinical and 25 randomly selected general medical papers (published in 1992) were evaluated with the help of checklists used in the British Medical Journal (BMJ). The result was compared with the survey conduct...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Vitrai J,Czobor P

    更新日期:1996-03-03 00:00:00

  • [The role of computed tomography perfusion in the diagnosis of brain ischaemic stroke].

    abstract:UNLABELLED:In recent years, the broad introduction of fast multidetector computed tomography (CT) systems and the availability of commercial software for perfusion analysis have made cerebral perfusion imaging with CT a practical technique for the clinical environment. AIM AND METHODS:This article reviews the use of C...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2008.28323

    authors: Halász S,Puskás T

    更新日期:2008-06-08 00:00:00

  • [The role of vinpocetine in the treatment of cerebrovascular diseases based in human studies].

    abstract:INTRODUCTION:It shows the importance of cerebrovascular diseases that they are the third main cause of death exceeded only by coronary artery diseases and cancer. Cerebral ischemia leads to irreversible brain damage, thereby it is important to rescue the hypoperfused areas. Patients without stroke but with chronic cere...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,meta分析

    doi:10.1556/OH.2007.28115

    authors: Bagoly E,Fehér G,Szapáry L

    更新日期:2007-07-22 00:00:00

  • [New perspective in immunotherapy: local imiquimod treatment].

    abstract::Imiquimod belongs to the family of synthetic small nucleotid-like molecules of imidazoquinolinamines. It is an immune response modifier with potent antiviral and antitumor effects, which are mediated by Toll-like receptors (TLR7 and TLR8). Imiquimod targets predominantly TLR7 expressing plasmacytoid dendritic cells an...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2010.28866

    authors: Kemény L,Nagy N

    更新日期:2010-05-09 00:00:00

  • [The impact factor and those who dislike it].

    abstract::Since its introduction in 1976, the impact factor is permanently a subject of both criticism and glorification. This paper gives an overview on what actually the reservations and objections attack. A closer look often reveals that the criticisms are not against the specific substantial features of the impact factor. T...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2015.30212

    authors: Schubert A

    更新日期:2015-06-28 00:00:00

  • [Cost/benefit calculations of meticillin-resistant Staphylococcus aureus screening methods and their practical importance].

    abstract::Nosocomial infections are the main cause of extra charges in health care and they relate to patient safety, as well. About 30 percent of healthcare-associated infections can be prevented effectively with infection control and adequate screening methods. Currently, meticillin-resistant Staphylococcus aureus is the main...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2010.28869

    authors: Knausz M,Kaproncai G,Rozgonyi F

    更新日期:2010-05-30 00:00:00

  • [Identifying rare genomic disorders with array comparative genomic hybridization in Hungary].

    abstract:INTRODUCTION:In the past decade the study of genomic disorders has received more interest. Array comparative genome hybridization is a widely spread diagnostic method in the research of genomic disorders. This method was implemented in the laboratory of the authors in 2012. AIM:This molecular cytogenetic method was fi...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2014.29825

    authors: Duga B,Czakó M,Hadzsiev K,Komlósi K,Sümegi K,Kisfali P,Kosztolányi G,Melegh B

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  • [New trend in treatment in patients with chronic hepatitis C].

    abstract::The combination of pegilált interferon plus ribavirin is significantly more effective than conventional interferon plus ribavirin, and is thus the current therapy of choice for patients with chronic hepatitis C. Forty-eight weeks of treatment with combination of pegilált interferon plus ribavirin has produced overall ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Werling K,Tulassay Z

    更新日期:2006-04-09 00:00:00