[New trend in treatment in patients with chronic hepatitis C].

Abstract:

:The combination of pegilált interferon plus ribavirin is significantly more effective than conventional interferon plus ribavirin, and is thus the current therapy of choice for patients with chronic hepatitis C. Forty-eight weeks of treatment with combination of pegilált interferon plus ribavirin has produced overall sustained virologic response 54-56% in patients with chronic hepatitis C. This article summarize the new therapy of chronic hepatitis C, the antiviral therapy of hepatitis C virus patients with normal aminotransferase levels, the therapy in patients with compensated cirrhosis and who were nonresponders to previous combination therapy, the effect of antiviral therapy on necroinflammation and fibrosis, and the favourable effect of haemopoetic growth factors on results of antiviral therapy. A substantial proportion of patients with chronic hepatitis C have persistently normal alanin-aminotransferase levels. Many studies have indeed provided evidence that although the majority of hepatitis C virus patients with normal alanin-aminotransferase may have active and progressive liver disease. Initiation of antiviral therapy might be decided mainly on the basis of histological findings. Extending the treatment duration from 48 to 72 weeks in patients with hepatitis C virus genotype 1 significantly reduces relapse rates and increases sustained virological rates. Induction phase with a higher dose of pegilált interferon may be of value in improving outcomes in patients with genotype 1 who were nonresponders to previous combination therapy. The combination of pegilált interferon and ribavirin was effective and well tolerated in patients with compensated cirrhosis. Interferon-based therapy may reduce hepatic inflammation in the absence of a sustained virologic response. This results suggest that interferon maintenance therapy may slow disease progression. The virologic response rates could be improved by utilizing haemopoetic growth factors, as opposed to reducing the ribavirin and interferon dose.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Werling K,Tulassay Z

subject

Has Abstract

pub_date

2006-04-09 00:00:00

pages

637-41

issue

14

eissn

0030-6002

issn

1788-6120

journal_volume

147

pub_type

杂志文章,评审
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    doi:

    authors: Hidasi V

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  • [Successful operation of bleeding perforated Curling's ulcer].

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    pub_type: 杂志文章

    doi:

    authors: Baksa J

    更新日期:1991-02-24 00:00:00

  • [Comparative study of combined local treatment (sulfadimidine, metronidazole and nystatin) and the standard monotherapy in uncomplicated bacterial vaginosis].

    abstract::Comparative, in vivo, human, prospective, single blind, clinical and microbiological diagnoses based and randomised study of the treatment of uncomplicated bacterial vaginosis with two forms of combined (metronidazole + nystatin + sulfadimidin) vaginal suppositories (laminated and mixed containing the same ingredients...

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    authors: Milánkovits M,Baksay L,Plachy J

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  • [The first vaccine against cancer: the human papillomavirus vaccine].

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    journal_title:Orvosi hetilap

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    doi:10.1556/OH.2013.29593

    authors: Bősze P

    更新日期:2013-04-21 00:00:00

  • [First detection of human metapneumovirus in a child with respiratory syndrome in Hungary].

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    doi:

    authors: Reuter G,Szabó H,Székely G,Gyurkovits K,György S

    更新日期:2006-12-03 00:00:00

  • [Neurology of cognition and language in the publications of Kálmán Sántha and today].

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    journal_title:Orvosi hetilap

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    authors: Szirmai I

    更新日期:2008-05-04 00:00:00

  • [Methods for in vivo investigation of human microcirculation].

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    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Boros M

    更新日期:2001-05-27 00:00:00

  • [Value of the Medicor CT 0100 equipment in a county hospital in the diagnosis of cerebrovascular diseases].

    abstract::Data of patients with CVD in the ward of the authors in the last quarters of 1986 and 1987 has been compared, in the second period they used a MEDICOR CT 0100 computer tomograph. The subsequent results are stressed: The rate of the patients with CVD in the Department of Neurology was approximately 40% in the studied p...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Horváth G,Szirmai I,Guseo A,Than Z

    更新日期:1990-01-14 00:00:00

  • [Control of tachycardia with intravenous amiodarone in acute left heart failure].

    abstract::The treatment of atrial tachycardia in critically ill patients can be difficult. Nine cases were presented with atrial tachyarrhythmias (mean heart rate > 130 beats/min) and left heart failure. Congestive heart failure was diagnosed in 6 patients (ejection fraction < 25%) and hypertensive heart failure in 3 patients (...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Tomcsányi J,Arabadzisz H,Zsoldos A,Marosi A,Beck K

    更新日期:2001-12-30 00:00:00

  • [De Quervain thyroiditis. Corner points of the diagnosis].

    abstract::Inflammatory disorders of the thyroid gland are divided into three groups according to their duration (acute, subacute and chronic). De Quervain's thyroiditis (also termed giant cell or granulomatous thyroiditis) is a subacute inflammation of the thyroid, which accounts for 5% of thyroid disorders. The etiology is unk...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2014.29865

    authors: Oláh R,Hajós P,Soós Z,Winkler G

    更新日期:2014-04-27 00:00:00

  • [High lactose content of the Lundh test meal adversely affects the reliability of the ALTAB test].

    abstract:UNLABELLED:The exocrine pancreatic function was examined in 20 patient without any detectable gastrointestinal disorder. We used 1 g 4(N-acetyl-L-thyrosil) aminobenzoic acid (ALTAB) an Lundh's test meal containing 25 g lactose, and the test was repeated with 3 g lactase (Galantase). The urine was collected for 6 hours ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Mikó P,Schreiner M,Fehér J

    更新日期:1990-03-25 00:00:00

  • [Preliminary experience with controlled lumbar drainage in medically refractory intracranial hypertension].

    abstract:INTRODUCTION:The contribution of brain edema to brain swelling in cases of traumatic brain injury remains a critical problem. In head injury, the swelling and eventual rise in intracranial pressure is a frequent cause of death, and in survivors the poor prognosis with sustained elevation of ICP has been well documented...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Tömösvári A,Mencser Z,Futó J,Hortobágyi A,Bodosi M,Barzó P

    更新日期:2005-01-23 00:00:00

  • [Treatment of pituitary adenomas].

    abstract::According to epidemiological studies, the prevalence of pituitary adenomas is 16.5% and the majority of them are "incidentalomas". The symptoms of pituitary disorders are often non-specific; disturbances of pituitary function, compression symptoms, hypophysis apoplexy or accidental findings may help the diagnosis. The...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2009.28584

    authors: Mezosi E,Nemes O

    更新日期:2009-09-27 00:00:00

  • [Dermatologic aspects of SAPHO-syndrome].

    abstract::SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis) as a new disease entity was first described in 1987. The syndrome is characterized by the presence of pustular dermatoses together with aseptic osteoarticular lesions. The bone involvement includes hyperostosis, aseptic osteomyelitis or arthritis of ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Károlyi Z,Harhai I,Erós N

    更新日期:2001-08-19 00:00:00

  • [Malignant cystosarcoma phyllodes: clinico-pathological conference in connection with two cases].

    abstract::Clinical and morphological characteristics of two malignant cystosarcoma phyllodes mammae were reported with the review of recent literature. One of the patients went to see her doctor 2 years after she had noticed the tumour because of "problems in her family". In the removed giant fibroadenoma osteo-chondrosarcomato...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Baláz M,Svastics E

    更新日期:1994-10-09 00:00:00

  • [Implantable pacemaker-cardioconverter-defibrillator].

    abstract::The aim of this article is to introduce the automatic, implantable cardioverter-defibrillator (AICD) device in connection with the first two cases in Hungary. At present time, the indications of the AICD implantation in the European Community are as follows: recurrent sustained episodes of ventricular tachycardia vent...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Richter T,Borbola J,Arvay A

    更新日期:1995-02-05 00:00:00

  • [Ayurveda for the treatment of obesity].

    abstract::Obesity is an increasing problem all over the world as the lifestyle changes and fast food chains gain popularity. In India, 31% of men and 29% of women are overweight, which is a growing trend over the last 11 years. Obesity increases the risk of many diseases such as cardiovascular diseases, reflux disease, gastroin...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2016.30534

    authors: Korossy A,Blázovics A

    更新日期:2016-08-01 00:00:00

  • Importance of the imaging techniques in the management of COVID-19-infected patients

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    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/650.2020.31814

    authors: Lovas A,Hankovszky P,Korsós A,Kupcsulik S,Molnár T,Szabó Z,Babik B

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  • [Isolation of free DNA from archived serum samples suitable for molecular genetic studies].

    abstract:INTRODUCTION:Collected and archived serum samples could be important sources for genetic studies, once DNA suitable for molecular genetic studies could be obtained from them. METHODS:DNA was isolated from 54 archived sera samples, collected previously from the participants of a Hungarian allergy study, with commercial...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Nagy B,Tarja L,Bán Z,Andrásofszky Z,Papp G,Lázár L,Nékám K,Papp Z,Réthy LA

    更新日期:2004-11-21 00:00:00

  • [Serum sex hormone-binding globulin levels in thyroid diseases].

    abstract::Synthesis of "sex-hormone binding globulin" is influenced by the thyroid hormones and its concentration in the serum may be a marker of the thyroid hormone effect at the peripheral tissue (liver) level. Compared to euthyroid controls serum "sex-hormone binding globulin" concentration is elevated in overt hyperthyroidi...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Földes J,Bános C,Lakatos P,Tarján G

    更新日期:1990-07-22 00:00:00

  • [Papillary renal cell carcinoma].

    abstract::The authors present a case of a papillary type renal cell carcinoma. The tumor is mostly discovered accidentally; a histopathological evaluation is indispensable for an exact diagnosis. Because of a better prognosis, differentiation of this tumor type from the classic variant of renal cell carcinoma is necessary, howe...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Glasz T,Rusz A,Doros A,Schaff Z

    更新日期:2001-08-12 00:00:00

  • [Postischemic inverted T waves: does gradual regression indicate improved prognosis?].

    abstract::This study has followed up the natural history of postischemic inverted T waves and assessed the prognosis. 40 consecutive patients with unstable angina with postischemic precordial inverted T waves in the noninfarcted, previously ischemic area were followed during the persistence (negative T wave period) and after re...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Simon K,Turi T,Szabó P,Szelier A,Szépvölgyi A,Sereg M,Szatmáry L

    更新日期:1993-12-05 00:00:00

  • [Morphological aspects of the effect of magnesium orotate therapy on changes in the vascular walls induced by cholesterol-rich diet].

    abstract::Heart and blood vessel disease are one of the leading causes of death, so their prevention and therapy are very important. In the present study the effects of magnesium chloride, magnesium orotate and orotic acid were tested. New Zealand rabbits were fed with enriched (2%) cholesterol diet during 112 days: starting wi...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Jellinek H,Takács E

    更新日期:1997-09-07 00:00:00

  • [The principles of the treatment of pancreatic diabetes].

    abstract::In pancreatic diabetes the whole of the Langerhans islets are damaged, which means that both the beta-cells and the alpha-cells are damaged. Unpredictable oscillations of blood glucose level are common due to malabsorption and maldigestion and one may count with explicit proneness to hypoglycaemia. The defence against...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2009.28486

    authors: Iván G

    更新日期:2009-02-08 00:00:00

  • [Comparative peroral cholecystography and ultrasonic study of the gallbladder].

    abstract::Authors--beside the admission of ultrasound examination's obvious priority--do not think that the complete cease of the gall-bladder's X-ray examination is reasonable. They have been found this on the basis of the literature and their own observations. Authors suggest the gall-bladder's examination after a negative ul...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Demeter J,Balogh I

    更新日期:1991-10-13 00:00:00

  • [Acute renal failure caused by plant extract].

    abstract::The authors review the case of a 30 years old female patient presenting with a 48 hours-standing anuria, who permanently used products of grist of a virtuous plant, Guarana and occasionally used a parenteral non-steroid painkiller. The clinical history and laboratory results showed acute renal and hepatic failure. The...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2007.27954

    authors: Vágási K,Degrell P,Késoi I,Kovács T,Pintér I,Molnár B,Cseh J,Nagy J,Wittmann I

    更新日期:2007-03-04 00:00:00

  • [Nurse style of central vein! Our experience in the peripherally inserted central venous catheter].

    abstract::What is PICC line insertion? The PICC is a soft, flexible catheter which is made of polyurethane or silicone, and is inserted via an upper or lower extremity peripheral vein into superior or inferior vena cava. The origin of PICC line dates back to the early 1950s. Since the introduction of the PICC catheter, this met...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/650.2017.30765

    authors: Kollár G,Alizadeh H,Gulyás E

    更新日期:2017-06-01 00:00:00

  • [Pancreatogenic panniculitis based on 2 cases].

    abstract::The rarest and hardly known complication of pancreas diseases is the subcutaneous nodular fat necrosis, a special type of panniculitides. It is mostly associated with pancreatitis and adenocarcinoma of pancreas. Its diagnostic criteria are (1) red painless or occasionally painful nodules showing a tendency of coalesce...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Kovács A,Krisztián E,Grósz M,Horváth T,Bálint L

    更新日期:1997-08-03 00:00:00

  • [Immunomodulation therapy in chronic bronchitis (multicenter study)].

    abstract::(A multicentre clinical trial) The authors treated 120 patients showing the symptoms of chronic bronchitis with BV or placebo for 6 months during the winter period of 1992-93 in a multicentre double-blind clinical trial. The status of the patients was evaluated monthly and the data were analyzed at an independent comp...

    journal_title:Orvosi hetilap

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Hutás I,Kraszkó P,Böszörményi Nagy G

    更新日期:1994-06-05 00:00:00

  • [Favourable effects of kidney transplantation on vascular condition of patients: Potential prognostic significance of non-invasive measurement of arterial stiffness].

    abstract:INTRODUCTION:Development of atherosclerosis is accelerated in kidney transplant patients. Impaired metabolic pathways have complex effect on the arterial wall which can be measured by non-invasive techniques. Only few data are available on the change of stiffness parameters in the postoperative course. Therefore, in th...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Kovács DÁ,Asztalos L,Laczik R,Fedor R,Szabó L,Lőcsey L,Soltész P

    更新日期:2016-06-12 00:00:00