[New perspective in immunotherapy: local imiquimod treatment].

Abstract:

:Imiquimod belongs to the family of synthetic small nucleotid-like molecules of imidazoquinolinamines. It is an immune response modifier with potent antiviral and antitumor effects, which are mediated by Toll-like receptors (TLR7 and TLR8). Imiquimod targets predominantly TLR7 expressing plasmacytoid dendritic cells and Langerhans cells, with secondary recruitment and activation of other inflammatory cells. Activation of TLR7 results in the stimulation of the innate and acquired immune responses, in particular cell mediated immune pathways. Topical imiquimod cream 5% (Aldara, MEDA Pharma) has been found to be effective for the treatment of actinic keratoses, superficial basal cell carcinoma and anogenital warts. Topical imiquimod is especially recommended for the treatment of large clinically asymptomatic fields containing tumor cells ("field cancerization"). Treatment with imiquimod applied at home by patient gives excellent cosmetic results. There are some data on its efficacy in nodular basal cell carcinoma and in some other skin cancers. The drug appears to be well tolerated with mild to moderate to local inflammation at the site of application. This paper provides a review about current experience and possible future development of imiquimod.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Kemény L,Nagy N

doi

10.1556/OH.2010.28866

subject

Has Abstract

pub_date

2010-05-09 00:00:00

pages

774-83

issue

19

eissn

0030-6002

issn

1788-6120

pii

0038401710277723

journal_volume

151

pub_type

杂志文章,评审
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    doi:

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  • [Reconstruction of the mandible using a vascularized graft from the iliac bone].

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    doi:

    authors: Kovács A,Horváth OP,Fehér A,Szendrényi V,Méray J,Mari A

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  • [Psychological factors of successful kidney transplantations. The effects of anxiety and intrapsychic integration of the organ on recovery].

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    doi:10.1556/OH.2012.29327

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    authors: Rudas L,Kardos A,Halmai L,Török T,Pap I

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  • [Vitamin D metabolism and osteoporosis in systemic sclerosis].

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    doi:

    authors: Wittmann I,Soltész G,Jermendy G,Nagy J

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  • [Quality assurance and quality improvement in medical practice - Part 2. Evidence-based medicine].

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    doi:10.1556/OH.2012.29292

    authors: Godény S

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  • [Vestibular control of the cardiovascular system].

    abstract::Due to modern living conditions the human cardiovascular system is frequently exposed to rapid or/and prolonged changes in gravitational forces. These transients are very short compared to the timescale of the evolution causing substantial difficulties in adaptation. As it has been many times proven experimentally sin...

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    doi:

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  • [The role of vaccination in the prevention of communicable diseases].

    abstract::The increasing role of vaccination in prevention of infectious diseases, the newly introduced vaccines and immunization systems are dealt with. Some recent and future alterations in the field of the basic vaccination system are discussed. Special emphasis is laid on the new vaccines and immunization methods which can ...

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    doi:

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  • [Unstable angina pectoris associated with surgically treated coronary artery atresia].

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  • [Right ventricular outflow tract reconstruction in adolescents and adults after previous repair of congenital heart defects].

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  • [Role of the activating mutation Val617Phe of Janus kinase 2 gene in myeloproliferative diseases and significance of its detection].

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  • [Applied methods instead of autologous nerve transplantation in the reconstruction of nerve injuries on the hand].

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    doi:

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  • [Tissue Doppler imaging in the assessment of right ventricular function in congenital heart disease. Correlation with echo-MRI].

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  • [Sjögren's syndrome and multiple myeloma].

    abstract::In our recent work we present two cases of coexisting Sjögren's syndrome and myeloma multiplex. Our results obtained studying a high number of patients suggest that the occurrence of myeloma in Sjögren's syndrome is much higher than in normal population. This can possibly be explained by the common pathogenetical fact...

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    doi:

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  • [Health behaviour of doctors].

    abstract:INTRODUCTION:Health behaviour involves maintaining, improving and restoration of health. AIM:The aim of the author was to assess correlations of health behaviour with age, gender, job type and overtime. METHOD:A quantitative cross-sectional study was conducted using an online questionnaire (N = 186). Data were analyz...

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  • [Movement-activated [15O]-butanol PET scan in patients with Parkinson disease].

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    doi:

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    doi:

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