Abstract:
:The authors give account of their study concerning the effect of paracetamol on the acid haemolysis, and glutathione content of human erythrocytes. In vitro, paracetamol decreased intracellular glutathione content in a dose dependent manner. This may lead to an increased sensitivity of erythrocytes to the haemolytic effect of hydrochloric acid, what may explain the dose dependent decrease of time of haemolysis, presented in form of dynamic haemolysis curve. In vivo four hours following the oral intake of 500 mg paracetamol, although the intracellular glutathione content did not decrease significantly, shortening of the time of acid haemolysis could be demonstrated in more than half of the persons studied. No haemolysis was caused by the given dose of the drug.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Altorjay I,Sári B,Imre S,Balla G,Dalmi Lsubject
Has Abstractpub_date
1993-10-10 00:00:00pages
2259-62issue
41eissn
0030-6002issn
1788-6120journal_volume
134pub_type
杂志文章相关文献
ORVOSI HETILAP文献大全abstract::Myotonic dystrophy is one of the most common, autosomal dominantly inherited adult-onset muscle disorders. Two types of the disease are known: type 1 is characterized by distal weakness and myotonia, but type 2 is associated with proximal weakness and milder clinical course. It is also called as Steinert Disease, whic...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2019.31505
更新日期:2019-09-01 00:00:00
abstract::A newborn is described, who was born in term with 3250 g weight, after intrauterine hypoxia. She was born with vacuum extraction, and suffered from birth trauma and intrauterine infection. At age of one day manifested an eclampsia, which was hardly diminishable. The serum Na level was 118 mmol/l. Bilateral adrenal apo...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1992-05-10 00:00:00
abstract:INTRODUCTION:The reason for unsuccessful tumor chemotherapy is related to multidrug resistance. An important factor is the overexpression of efflux pumps, such as P-glycoprotein. AIM:Amino- and amide-substituted steroid compounds and phenothiazine derivatives were investigated in tumor models in vitro. METHOD:The inh...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2016.30536
更新日期:2016-09-01 00:00:00
abstract:INTRODUCTION:Nowadays doctor-patient consultation is not limited to personal appointments, there are new technical possibilities to keep contact. AIM:The aim of our study was to examine the way in which the doctor and patient interact with each other between two personal consultations and how the patients would like t...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2018.31209
更新日期:2018-12-01 00:00:00
abstract::.15, 0.25 and 0.5 g/kg alcohol in the form of 40% brandy in one week intervals was consumed by eight healthy, regularly trained young men volunteers. Blood alcohol level, blood pressure and ECG were registered before and 30, 60 and 90 min after, each alcohol consumption. The cardiac output was measured with a radiocir...
journal_title:Orvosi hetilap
pub_type: 临床试验,杂志文章,评审
doi:
更新日期:1989-12-24 00:00:00
abstract::Myocardial infarction is the leading cause of congestive heart failure in the industrialized world. Current treatments fail to address the underlying scarring and cell loss, which are the causes of ischaemic heart failure. Recent interest has focused on stem cells, which are undifferentiated and pluripotent cells that...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2005-11-20 00:00:00
abstract::One year follow up(1.5, 3, 6, 12 months) study was established to examine the role of several classes of drugs in the treatment of reflux disease in 40 patients on the basis of objective control parameters (pH-metry, endoscopy, histology). The therapy was initiated, respectively, the different stage of severity (Savar...
journal_title:Orvosi hetilap
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:
更新日期:1998-05-03 00:00:00
abstract::After bone marrow transplantation, a prolonged dysregulation of humoral immunity, including restricted electrophoretic heterogeneity of serum immunoglobulins and the appearance of homogeneous immunoglobulin components, can be observed. The current study was undertaken to characterize further and define the posttranspl...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2001-02-11 00:00:00
abstract::Similarly to an increase in life expectancy, the incidence of Parkinson's disease increases as well. In parallel with this, more patients with Parkinson's disease undergo elective or urgent surgical interventions. According to recent statistical data, more than half of the patients with Parkinson's disease are not pro...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/650.2015.30233
更新日期:2015-08-23 00:00:00
abstract::The author analyzes the applicability of the renin-angiotensin system blocking drugs in patients with chronic kidney disease emphasizing their renoprotective (blood pressure and albuminuria lowering) and cardiovascular risk decreasing effects. As opposed to a previously-published statement, the author believes that th...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2013.29609
更新日期:2013-05-12 00:00:00
abstract:INTRODUCTION:The internationalization of societies and the processes of globalization raise new challenges towards health provision systems, including professional, ethical, social, cultural and communicational references of nursing and nursing education. AIMS:In this study the authors wanted to answer the following q...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2012.29479
更新日期:2012-10-28 00:00:00
abstract:UNLABELLED:The need of outcome measures from the patients' aspect emerges reasonably in the field of rapidly developing pediatric cardiac surgery and pediatric cardiology. The professional standards and the possibilities of applicability of quality of life measures are often unknown for medical doctors. This is particu...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2008.28278
更新日期:2008-09-14 00:00:00
abstract:INTRODUCTION:Religious addiction is a new behavioral addiction, featured with pathologic religious activity. AIM:The authors examined whether this new phenomenon appears in adolescence, and whether it correlates with substance use and mental health variables. METHOD:The General Addiction Screening Tool was used to in...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2015.30137
更新日期:2015-05-03 00:00:00
abstract::Primary liver cancer is the fifth most common cancer worldwide. Hepatocellular carcinoma accounts for 85-90% of primary liver cancers. Distribution of hepatocellular carcinoma shows variations among geographic regions and ethnic groups. Males have higher liver cancer rates than females. Hepatocellular carcinoma occurs...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2008.28313
更新日期:2008-03-23 00:00:00
abstract::The Val617Phe point mutation of Janus kinase 2 gene is believed to participate in the pathogenesis of myeloproliferative syndrome characterised by the clonal alteration of hematopoietic stem cells. According to current results, the frequency of Val617Phe activating mutation is around 80% in polycythaemia vera, 35% in ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2007.27860
更新日期:2007-02-04 00:00:00
abstract::Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The morbidity is about 1-2 of 1000 under 65 years, but it increases to 1-2 of 100 in the population over 65 years. PD became the model of degenerative disorders either concerning the etiopathogenesis or the therapeutic possibilities. Recen...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2000-03-05 00:00:00
abstract:UNLABELLED:Rheumatoid arthritis (RA) is a chronic, progressive polyarthritis leading to substantial disability. Standardised data on consequences of disease progression are needed for clinical assessments and also for cost-effectiveness models. AIM:To analyse the impact of disease progression on health status, disease...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2008.28294
更新日期:2008-04-20 00:00:00
abstract::The aim of the retrospective study was to analyse the frequency of polyps, anamnestic data and the result of histological examination overviewing 163 polyps which was find during 1900 hysteroscopy. In the history of patients dilatation and curettage was find in 22% one time and in 6.6% two times, but the polyps were r...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1999-09-12 00:00:00
abstract::Clinical data of 34 patients with DM, who have been treated during the years 1971 and 1998 were evaluated. 79% of the patients (27 patients) were female, 21% of them (7 patients) were male. 59% of the patients (20 pts) were between the ages of 41 and 50 years. The characteristic heliotrop rash were observed in 26 pati...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2000-01-30 00:00:00
abstract:INTRODUCTION:Development of atherosclerosis is accelerated in kidney transplant patients. Impaired metabolic pathways have complex effect on the arterial wall which can be measured by non-invasive techniques. Only few data are available on the change of stiffness parameters in the postoperative course. Therefore, in th...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2016-06-12 00:00:00
abstract::The susceptibility of women to autoimmune diseases is well-documented, of which systemic lupus erythematosus (SLE) is especially important. The use of oral contraceptives often activate SLE from a quiescent condition. The inductive effect of estrogen has been shown in animal studies indicating that female hormones c...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1987-12-20 00:00:00
abstract::The combination of pegilált interferon plus ribavirin is significantly more effective than conventional interferon plus ribavirin, and is thus the current therapy of choice for patients with chronic hepatitis C. Forty-eight weeks of treatment with combination of pegilált interferon plus ribavirin has produced overall ...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2006-04-09 00:00:00
abstract::The Curling's ulcer is a special form of the stress ulcers which occurs in the stomach and duodenum in 2.0-25%. It's pathogenesis is unknown even though it is clearly related to larger burns poor early treatment and septic complications. Since the institution of routine prophylaxis of H2 receptor antagonists and antac...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1991-02-24 00:00:00
abstract::In our recent work we present two cases of coexisting Sjögren's syndrome and myeloma multiplex. Our results obtained studying a high number of patients suggest that the occurrence of myeloma in Sjögren's syndrome is much higher than in normal population. This can possibly be explained by the common pathogenetical fact...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2000-09-17 00:00:00
abstract:INTRODUCTION:Adult-onset acid maltase deficiency myopathy is a rare lysosomal storage disease with an autosomal recessive pattern of inheritance. The disease can be manifested with respiratory insufficiency and fatigue. METHODS:A case of a 45-year-old male patient is presented, and difficulty in diagnosis is discussed...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2006-07-30 00:00:00
abstract::Neuroendocrine neoplasms belong to the group of rare tumours. Their clinical importance may be highlighted by their high prevalence despite low incidence. Since survival rate is similar to other progressive neoplastic diseases in metastatic cases, early recognition and appropriate therapy of these neoplasms are equall...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2013.29716
更新日期:2013-09-29 00:00:00
abstract::The diagnosis of phaeocromocytoma could be excluded in a 57 year-old man suffering from "typical" hypertensive paroxysms by using modern standardized technics. The presented disorder which has been named pseudophaeochromocytoma may include different pathogenetical entities. In the observed case the background of the d...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1993-04-25 00:00:00
abstract::Acute porphyrias are caused by the inherited decreased activity of the enzymes of the heme biosynthesis pathway. Depending on the affected enzyme there are 4 types of them: acute intermittent porphyria, porphyria variegata, coproporphyria and delta-aminolevulinic acid dehydratase deficient porphyria, listed in order o...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2003-05-11 00:00:00
abstract::The authors report a comparative study on the effects of ketotifen and oxatomide on repeated provocation of the skin and the nasal mucosa in 16 children (4 girls and 12 boys, average age 12.0 +/- 3.25 yr) with diagnosed seasonal allergic rhinitis. Preceding and following a 4-week ketotifen or oxatomide treatment, a qu...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1990-02-18 00:00:00
abstract::Three-dimensional speckle-tracking echocardiography is a new cardiac imaging methodology, which allows three-dimensional non-invasive evaluation of the myocardial mechanics. The aim of this review is to present this new tool emphasizing its diagnostic potentials and demonstrating its limitations, as well. ...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2012.29466
更新日期:2012-10-07 00:00:00