Abstract：
OBJECTIVES:The objective of this study is to characterize the common risk factors, clinical presentation, imaging findings, treatment and outcome of nocardial infection. DESIGN AND SETTINGS:A retrospective cohort study. We reviewed the charts of all patients with nocardiosis in the Chaim Sheba Medical Center, a tertiary medical center in Israel, between the years 1996 and 2011. RESULTS:A total of 39 patients who had positive culture of Nocardia were analyzed. The majority of our patients were immunocompromised (74.5%), mostly due to corticosteroid therapy. None had HIV/AIDS. The clinical presentation was either acute or a chronic smoldering illness. The three major clinical syndromes were pleuropulmonary, neurological and skin/soft tissue infection about 20.5% each. Pathology in the lungs was seen in most of the patients by CT scan; discrete nodules and wedge shaped pleural based consolidations were the most frequent findings. Brain lesions consistent with abscesses were detected in 10 patients by brain imaging. Some cases had relapsing disease in spite of antimicrobial treatment. 25% of examined isolates were resistant to trimethoprim/sulfamethoxazole. The duration of intravenous antimicrobial treatment ranged from one month to over a year in the severe cases. One year mortality rate was 32%. CONCLUSION:Nocardiosis requires a high clinical index of suspicion in order to diagnose and treat promptly. Disease extent and bacterial susceptibility have important implications for prognosis and treatment.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Rosman Y,Grossman E,Keller N,Thaler M,Eviatar T,Hoffman C,Apter Sdoi
10.1016/j.ejim.2013.05.004subject
Has Abstractpub_date
2013-09-01 00:00:00pages
552-7issue
6eissn
0953-6205issn
1879-0828pii
S0953-6205(13)00132-5journal_volume
24pub_type
杂志文章abstract：:Patients with systemic lupus erythematosus (SLE) are frequently immunodepressed making them more vulnerable to infections. Preventive vaccination is therefore warranted but has often been withheld owing to fears of a link between infection and autoimmunity, and the possibility of inducing or exacerbating lupus after v...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2008.07.017
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:Prealbumin is a maker of nutritional status and inflammation of potential prognostic value in acute heart failure (HF). The aim of this study is to evaluate if low prealbumin levels on admission predict mortality and readmissions in patients with acute HF. METHOD:We conducted a prospective observational coh...
journal_title：European journal of internal medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ejim.2017.05.009
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVE:18F-FDG PET/CT can detect large-vessel involvement in giant-cell arteritis (GCA) with a good sensitivity. In patients with clinically and biologically controlled disease, we aimed to assess how vascular uptakes evolve on repetitive FDG-PET/CT. PATIENTS AND METHODS:All included patients had to satisfy the 4 f...
journal_title：European journal of internal medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ejim.2017.08.013
更新日期：2017-12-01 00:00:00
abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) is a well-recognized major cause of nosocomial infection worldwide. During the past decade, however, the epidemiology of staphylococcal infections has partially changed, with an increase in the number of patients who acquire infections in the community. The changing e...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2008.08.016
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abstract：:The International Society of Hypertension (ISH) has recently developed practice guidelines for the management of hypertension in adults aged ≥18 years. Conceptually, the 2020 ISH Guidelines are closer to the 2018 ESC/ESH Guidelines rather than to the 2017 ACC/AHA Guidelines. The ISH Guidelines have two distinctive fea...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2020.09.001
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abstract：:Thrombangiitis obliterans (TAO), or Buerger's disease, is most likely an endarteritis that is introduced by T-cell-mediated cellular immunity and B-cell-mediated humoral immunity associated with the activation of macrophages or dendritic cells in the intima. There is no specific marker of the disease, and the diagnosi...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2005.11.020
更新日期：2006-07-01 00:00:00
abstract：:All major antihypertensive drug classes i.e. diuretics, beta-blockers, calcium antagonists and blockers of the renin-angiotensin system have been shown to effectively lower blood pressure and hence to reduce cardiovascular outcomes in hypertensive patients. These drugs decrease cardiovascular complications in hyperten...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2010.08.008
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abstract：OBJECTIVES:This study investigated the correlation between Helicobacter pylori (HP) and cancer risk. We compared the age, sex, and comorbidity of cancer patients both infected and not infected by HP. METHODS:In this study, we compared a comparison cohort (N=24,088) and an HP cohort (N=6022), both taken from the NHI da...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2014.01.009
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Few data on patterns of care and outcomes are available for elderly patients with diffuse large B-cell lymphoma (DLBCL) outside of clinical trials. METHODS:We identified patients with DLBCL older than 60 years from a regional cancer registry between 2000 and 2010. Based on registry data and chart review, 12...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2014.05.001
更新日期：2014-07-01 00:00:00
abstract：:We describe an 80-year-old patient who developed Staphylococcus aureus septicemia several days after the implantation of a double stent in the proximal and mid-left anterior descending artery. The infection was complicated by multiple abscesses in the lungs and liver, as well as by bilateral bacterial endophthalmitis ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2004.10.010
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND/AIM:The spontaneous preterm birth (SPB) rates in a group of HBeAg-negative chronic HBV infected pregnant women without several known risk factors for preterm delivery as well as the mother to infant HBV transmission rates was evaluated. Moreover the role of maternal data during perinatal period as well as th...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2010.12.005
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:One of the major threats looming over the growing older population is frailty. It is a distinctive health state characterised by increased vulnerability to internal and external stressors. Although the presence of frailty is well acknowledged, its concept and operationalisation are hampered by the extraordin...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2018.04.023
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND & AIMS:There is limited data comparing influence of age on the presentation, clinical course, and therapeutic response of patients with ulcerative colitis. We aimed to compare the demographic and clinical characteristics of patients diagnosed with UC in older age vs. adulthood vs. early age. METHODS:Five-hu...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2012.12.014
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Hyperuricemia prognostic impact on clinical outcomes in chronic heart failure (HF) patients has been investigated with inconclusive results. OBJECTIVES:Aim of the study was to evaluate the prognostic impact of serum uric acid (SUA) on long-term clinical outcomes in HF. METHODS:An analysis of MECKI (Metabol...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2019.11.003
更新日期：2020-02-01 00:00:00
abstract：:Cough, a defense mechanism for clearing the airways of secretions, exudate, or foreign bodies, may become a troublesome symptom. Chronic cough, one of the most frequent symptoms requiring medical attention, is often not due to identifiable causes in adults. Chronic productive cough defines chronic bronchitis, and thus...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2020.03.018
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Many activities contribute to reduce drug-related problems. Among them, the medication reconciliation (MR) is used to compare the best possible medication history (BPMH) and the current admission medication order (AMO) to identify and solve unintended medication discrepancies (UMD). This study aims to assess...
journal_title：European journal of internal medicine
pub_type： 临床试验,杂志文章
doi：10.1016/j.ejim.2014.09.012
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Multimorbidity is a huge burden to individuals and societies and more attention should be paid on its risk factors and prevention possibilities. The aim of this study was to investigate which clinical and lifestyle characteristics predict the development of multimorbidity both among initially disease-free pe...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2015.02.012
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Mallory-Weiss syndrome is defined by upper gastrointestinal bleeding from vomiting-induced mucosal lacerations at the esophago-gastric junction. This study was purposed to investigate the incidence, location, clinical manifestation, diagnosis and effectiveness of treatment (including endoscopic treatment and...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2012.02.005
更新日期：2012-06-01 00:00:00
abstract：:Biologics embrace a wide range of substances synthesized by cells or living organisms by means of different biological processes, including recombinant DNA technology, controlled gene expression, or antibody technologies. A biosimilar establishes similarity to the reference medicinal product in terms of quality charac...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2016.06.005
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Porphyrias are a group of metabolic diseases, individually rare but with an important combined prevalence. Because of their pathological complexity and clinical heterogeneity, they present a challenging diagnosis. The present review aims to provide a clinically based approach to the recognition and treatment...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
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更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:To assess security of "blind" percutaneous liver biopsy as an ambulatory procedure. MATERIAL AND METHODS:Defining inclusion criteria, surveillance protocol, data from ultrasonography done 6 h after procedure and complications. RESULTS:We analysed 192 percutaneous liver biopsies done between 2000-2007. There...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2009.02.002
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:This study investigates risk factors and the incidence of type 2 diabetes mellitus (type 2 DM) in both sexes of a northern European population. METHODS:A total of 14,223 randomly selected men and women were studied from 1976 to 1978. Patients with diabetes (self-reported type 2 DM or non-fasting plasma gluc...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2007.05.011
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The aims of the present study were to determine both clinical manifestations and outcome of anti-PL7 patients with antisynthetase syndrome (ASS). METHODS:The medical records of 15 consecutive anti-PL7 patients with biopsy proven ASS were retrospectively analyzed without prior selection. RESULTS:Anti-PL7 pa...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2013.01.002
更新日期：2013-07-01 00:00:00
abstract：INTRODUCTION:Acute admissions to hospital are rising. As a part of a service evaluation we examined pathways of patients following hospital discharge depending on data available on admission to hospital. METHODS:We merged data available on admission to the Wrexham Maelor hospital from an existing data-base in the Acut...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2017.09.029
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:The activation of complement system is associated with the development of hepatitis B virus-associated membranous nephropathy (HBV-MN) and heparin could inhibit the activation of complement system. METHODS:This was a three-center trial. Seventy-nine patients with HBV-MN participated in the study. The follow...
journal_title：European journal of internal medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ejim.2016.04.017
更新日期：2016-07-01 00:00:00
abstract：:We report the case of a 59-year-old man with a pheochromocytoma in which erectile dysfunction was the main symptom. Erectile function was related to the amount of noradrenaline secreted by the tumor, as was determined when recurrence of the malignancy was diagnosed twice. Erectile function could be restored by lowerin...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2007.02.027
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:Antiphospholipid antibodies, the hallmark of the antiphospholipid syndrome, are associated with both venous and arterial thrombosis. Despite some reports stating that this association may be present in patients with low titres of anticardiolipin antibodies, a clear association has only been established in th...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2009.12.010
更新日期：2010-04-01 00:00:00
abstract：:The introduction of substrate reduction therapy (SRT) using miglustat (Zavesca(R)) gives physicians and patients a choice of treatment options for type 1 Gaucher's disease. Enzyme replacement therapy (ERT) has proven a successful approach to treating the haematologic abnormalities and organomegaly. However, long-term ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2006.07.003
更新日期：2006-11-01 00:00:00
abstract：:In recent years, new concepts of educational theory and practice have stimulated new approaches to medical education in many countries. For various reasons, medical education in Ireland has been slow to change such that there are now increasing concerns about educational standards. In addition, Ireland currently produ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2006.09.001
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVE OF THE STUDY:To report on the results of two projects on chronic hepatitis B in Western Balkans lead by Ioannina, Northwest Greece and Tirana, Albania. METHODS:In two prospective projects, HEPAGA I and HEPAGA II which lasted 4 years. In HEPAGA I, serum samples from 410 Albanians were tested for HBV. In HEPAG...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2009.07.016
更新日期：2009-11-01 00:00:00
