The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses.

Abstract:

:Complementary DNA clones encoding the murine homolog (mCAR) of the human coxsackievirus and adenovirus receptor (CAR) were isolated. Nonpermissive CHO cells transfected with mCAR cDNA became susceptible to infection by coxsackieviruses B3 and B4 and showed increased susceptibility to adenovirus-mediated gene transfer. These results indicate that the same receptor is responsible for virus interactions with both murine and human cells. Analysis of receptor expression in human and murine tissues should be useful in defining factors governing virus tropism in vivo.

journal_name

J Virol

journal_title

Journal of virology

authors

Bergelson JM,Krithivas A,Celi L,Droguett G,Horwitz MS,Wickham T,Crowell RL,Finberg RW

doi

10.1128/JVI.72.1.415-419.1998

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

415-9

issue

1

eissn

0022-538X

issn

1098-5514

journal_volume

72

pub_type

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