The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses.


:Complementary DNA clones encoding the murine homolog (mCAR) of the human coxsackievirus and adenovirus receptor (CAR) were isolated. Nonpermissive CHO cells transfected with mCAR cDNA became susceptible to infection by coxsackieviruses B3 and B4 and showed increased susceptibility to adenovirus-mediated gene transfer. These results indicate that the same receptor is responsible for virus interactions with both murine and human cells. Analysis of receptor expression in human and murine tissues should be useful in defining factors governing virus tropism in vivo.


J Virol


Journal of virology


Bergelson JM,Krithivas A,Celi L,Droguett G,Horwitz MS,Wickham T,Crowell RL,Finberg RW




Has Abstract


1998-01-01 00:00:00












  • Mitochondrial calcium uptake during infection of chicken embryo cells with Semliki Forest virus.

    abstract::The key role of the mitochondria in the regulation of cellular Ca2+ led to a study of mitochondrial Ca2+ uptake during the infection of chicken embryo cells with Semliki Forest virus. Mitochondrial Ca2+ uptake was stimulated during the first 5 h of infection but declined later in infection. The early stimulation sugge...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Peterhans E,Haenggeli E,Wild P,Wyler R

    更新日期:1979-01-01 00:00:00

  • Replication process of the parvovirus H-1. II. Isolation and characterization of H-1 replicative form DNA.

    abstract::The Parvovirus H-1 replicates autonomously in hamster embryo cells. A DNA synthetic event, called HA-DNA synthesis, upon which subsequent viral RNA and viral hemagglutinin synthesis is dependent, is initiated in late S phase of the infected cell (18). It was postulated that HA-DNA represents parental viral replicative...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Rhode SL 3rd

    更新日期:1974-02-01 00:00:00

  • Immunogenicity and protective efficacy of DNA vaccines expressing rhesus cytomegalovirus glycoprotein B, phosphoprotein 65-2, and viral interleukin-10 in rhesus macaques.

    abstract::Rhesus cytomegalovirus (RhCMV) infection of macaques exhibits strong similarities to human CMV (HCMV) persistence and pathogenesis. The immunogenicity of DNA vaccines encoding three RhCMV proteins (a truncated version of glycoprotein B lacking the transmembrane region and endodomain [gBDeltaTM], phosphoprotein 65-2 [p...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Yue Y,Kaur A,Eberhardt MK,Kassis N,Zhou SS,Tarantal AF,Barry PA

    更新日期:2007-02-01 00:00:00

  • Control of heterologous hepatitis C virus infection in chimpanzees is associated with the quality of vaccine-induced peripheral T-helper immune response.

    abstract::Prophylactic hepatitis C virus (HCV) vaccine trials with human volunteers are pending. There is an important need for immunological end points which correlate with vaccine efficacy and which do not involve invasive procedures, such as liver biopsies. By using a multicomponent DNA priming-protein boosting vaccine strat...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Rollier C,Depla E,Drexhage JA,Verschoor EJ,Verstrepen BE,Fatmi A,Brinster C,Fournillier A,Whelan JA,Whelan M,Jacobs D,Maertens G,Inchauspé G,Heeney JL

    更新日期:2004-01-01 00:00:00

  • Characterization of the pleiotropic effects of the genotype G-specific 36-nucleotide insertion in the context of other hepatitis B virus genotypes.

    abstract::The pregenomic RNA (pgRNA) of hepatitis B virus (HBV) serves as the messenger for both core and P proteins, with the downstream P gene translated by ribosomal leaky scanning. HBV replication begins with packaging of the pgRNA and P protein into core protein particles, followed by conversion of RNA into DNA. Genotype G...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Gutelius D,Li J,Wands J,Tong S

    更新日期:2011-12-01 00:00:00

  • Restriction of HIV-1 by rhesus TRIM5α is governed by alpha helices in the Linker2 region.

    abstract:UNLABELLED:TRIM5α proteins are a potent barrier to the cross-species transmission of retroviruses. TRIM5α proteins exhibit an ability to self-associate at many levels, ultimately leading to the formation of protein assemblies with hexagonal symmetry in vitro and cytoplasmic assemblies when expressed in cells. However, ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Sastri J,Johnsen L,Smolin N,Imam S,Mukherjee S,Lukic Z,Brandariz-Nuñez A,Robia SL,Diaz-Griffero F,Wiethoff C,Campbell EM

    更新日期:2014-08-01 00:00:00

  • Induction of nephroblastoma by myeloblastosis-associated virus type 1: state of proviral DNAs in tumor cells.

    abstract::Myeloblastosis-associated virus type 1 (MAV1) derived from a molecular clone of infectious proviral DNA (B. Perbal, J. S. Lipsick, J. Svoboda, R. F. Silva, and M. A. Baluda, J. Virol. 56:240-244, 1985) was shown to specifically induce nephroblastoma in chickens and therefore belongs to the MAV-N class. We show that ne...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Soret J,Dambrine G,Perbal B

    更新日期:1989-04-01 00:00:00

  • Dual Function of the pUL7-pUL51 Tegument Protein Complex in Herpes Simplex Virus 1 Infection.

    abstract::The tegument of herpesviruses is a highly complex structural layer between the nucleocapsid and the envelope of virions. Tegument proteins play both structural and regulatory functions during replication and spread, but the interactions and functions of many of these proteins are poorly understood. Here we focus on tw...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Albecka A,Owen DJ,Ivanova L,Brun J,Liman R,Davies L,Ahmed MF,Colaco S,Hollinshead M,Graham SC,Crump CM

    更新日期:2017-01-03 00:00:00

  • Intracellular route of canine parvovirus entry.

    abstract::The present study was designed to investigate the endocytic pathway involved in canine parvovirus (CPV) infection. Reduced temperature (18 degrees C) or the microtubule-depolymerizing drug nocodazole was found to inhibit productive infection of canine A72 cells by CPV and caused CPV to be retained in cytoplasmic vesic...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Vihinen-Ranta M,Kalela A,Mäkinen P,Kakkola L,Marjomäki V,Vuento M

    更新日期:1998-01-01 00:00:00

  • High pathogenicity of wild-type measles virus infection in CD150 (SLAM) transgenic mice.

    abstract::Measles virus (MV) infection causes an acute childhood disease, associated in certain cases with infection of the central nervous system and development of a severe neurological disease. We have generated transgenic mice ubiquitously expressing the human protein SLAM (signaling lymphocytic activation molecule), or CD1...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Sellin CI,Davoust N,Guillaume V,Baas D,Belin MF,Buckland R,Wild TF,Horvat B

    更新日期:2006-07-01 00:00:00

  • Analysis of poliovirus protein 3A interactions with viral and cellular proteins in infected cells.

    abstract::Poliovirus proteins 3A and 3AB are small, membrane-binding proteins that play multiple roles in viral RNA replication complex formation and function. In the infected cell, these proteins associate with other viral and cellular proteins as part of a supramolecular complex whose structure and composition are unknown. We...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Teterina NL,Pinto Y,Weaver JD,Jensen KS,Ehrenfeld E

    更新日期:2011-05-01 00:00:00

  • Epstein-Barr Virus-Induced Nodules on Viral Replication Compartments Contain RNA Processing Proteins and a Viral Long Noncoding RNA.

    abstract::Profound alterations in host cell nuclear architecture accompany the lytic phase of Epstein-Barr virus (EBV) infection. Viral replication compartments assemble, host chromatin marginalizes to the nuclear periphery, cytoplasmic poly(A)-binding protein translocates to the nucleus, and polyadenylated mRNAs are sequestere...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Park R,Miller G

    更新日期:2018-09-26 00:00:00

  • Carboxy-terminally truncated dengue virus envelope glycoproteins expressed on the cell surface and secreted extracellularly exhibit increased immunogenicity in mice.

    abstract::Recombinant vaccinia viruses expressing C-terminally truncated E's that ranged in length from 9 to 99% of the N-terminal sequence were constructed. The overall antigenicity of the E products was analyzed by radioimmunoprecipitation, using dengue virus hyperimmune mouse ascitic fluid (HMAF) or an anti-E peptide serum. ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Men RH,Bray M,Lai CJ

    更新日期:1991-03-01 00:00:00

  • Using chimeric hypoviruses to fine-tune the interaction between a pathogenic fungus and its plant host.

    abstract::Infectious cDNA clones of mild (CHV1-Euro7) and severe (CHV1-EP713) hypovirus strains responsible for virulence attenuation (hypovirulence) of the chestnut blight fungus Cryphonectria parasitica were used to construct viable chimeric viruses. Differences in virus-mediated alterations of fungal colony morphology, growt...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Chen B,Geletka LM,Nuss DL

    更新日期:2000-08-01 00:00:00

  • Mobility of endogenous ecotropic murine leukemia viral genomes within mouse chromosomal DNA and integration of a mink cell focus-forming virus-type recombinant provirus in the germ line.

    abstract::Characterization of endogenous ecotropic Akv proviruses in DNA of low and high leukemic mouse strains revealed the presence of one to six copies of the Akv genome per haploid genome equivalent integrated in the germ line. Low leukemic strains analyzed so far contained only one complete copy of the Akv proviral DNA. Th...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Quint W,van der Putten H,Janssen F,Berns A

    更新日期:1982-03-01 00:00:00

  • Insertional polymorphisms of endogenous feline leukemia viruses.

    abstract::The number, chromosomal distribution, and insertional polymorphisms of endogenous feline leukemia viruses (enFeLVs) were determined in four domestic cats (Burmese, Egyptian Mau, Persian, and nonbreed) using fluorescent in situ hybridization and radiation hybrid mapping. Twenty-nine distinct enFeLV loci were detected a...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Roca AL,Nash WG,Menninger JC,Murphy WJ,O'Brien SJ

    更新日期:2005-04-01 00:00:00

  • Expression of the Autographa californica nuclear polyhedrosis virus apoptotic suppressor gene p35 in nonpermissive Spodoptera littoralis cells.

    abstract::Apoptosis was postulated as the main barrier to replication of the Autographa californica nuclear polyhedrosis virus (AcMNPV) in a Spodoptera littoralis SL2 cell line (N. Chejanovsky and E. Gershburg, Virology 209:519-525, 1995). Thus, we hypothesized that the viral apoptotic suppressor gene p35 is either poorly expre...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Gershburg E,Rivkin H,Chejanovsky N

    更新日期:1997-10-01 00:00:00

  • Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection.

    abstract:UNLABELLED:The extreme stability of the latent HIV-1 reservoir in the CD4(+) memory T cell population prevents viral eradication with current antiretroviral therapy. It has been demonstrated that homeostatic T cell proliferation and clonal expansion of latently infected T cells due to viral integration into specific ge...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Seu L,Sabbaj S,Duverger A,Wagner F,Anderson JC,Davies E,Wolschendorf F,Willey CD,Saag MS,Goepfert P,Kutsch O

    更新日期:2015-07-01 00:00:00

  • Simian varicella virus expresses a latency-associated transcript that is antisense to open reading frame 61 (ICP0) mRNA in neural ganglia of latently infected monkeys.

    abstract::Simian varicella virus (SVV) and varicella-zoster virus (VZV) are closely related alphaherpesviruses that cause varicella (chickenpox) in nonhuman primates and humans, respectively. After resolution of the primary disease, SVV and VZV establish latent infection of neural ganglia and may later reactivate to cause a sec...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Ou Y,Davis KA,Traina-Dorge V,Gray WL

    更新日期:2007-08-01 00:00:00

  • Mutations in E2-PePHD, NS5A-PKRBD, NS5A-ISDR, and NS5A-V3 of hepatitis C virus genotype 1 and their relationships to pegylated interferon-ribavirin treatment responses.

    abstract::Mutations in several subgenomic regions of hepatitis C virus (HCV) have been implicated in influencing the response to interferon (IFN) therapy. Sequences within HCV NS5A (PKR binding domain [PKRBD], IFN sensitivity-determining region [ISDR], and variable region 3 [V3]) were analyzed for the pretreatment serum samples...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Muñoz de Rueda P,Casado J,Patón R,Quintero D,Palacios A,Gila A,Quiles R,León J,Ruiz-Extremera A,Salmerón J

    更新日期:2008-07-01 00:00:00

  • Human immunodeficiency virus type 1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity.

    abstract::Chimeric human immunodeficiency virus type 1 (HIV-1) molecular clones differing only in the envelope V3 region were constructed. The V3 regions were derived from two HIV-1 isolates with a non-syncytium-inducing, non-T-cell-tropic phenotype and from four HIV-1 isolates with a syncytium-inducing, T-cell-tropic phenotype...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: de Jong JJ,Goudsmit J,Keulen W,Klaver B,Krone W,Tersmette M,de Ronde A

    更新日期:1992-02-01 00:00:00

  • Isolation and characterization of a heat-inducible simian virus 40 mutant.

    abstract::We have isolated a new type of temperature-sensitive mutant of simian virus 40 (SV40) that is capable of productive infection in permissive cells but not of maintenance of viral DNA integration in transformed cells at the conditional temperature. Virus development is induced when cells transformed by this mutant are s...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Rothschild H,Lockwood MP

    更新日期:1976-08-01 00:00:00

  • Genomic cloning and complete sequence analysis of a highly divergent African human immunodeficiency virus isolate.

    abstract::Analysis of the complete sequence of a human immunodeficiency virus (HIV) isolate (Ant70) obtained from a Cameroonian patient indicates that this virus is the most divergent strain within the HIV-1 family hitherto described. Comparison of the Pol protein, usually highly conserved within the HIV-1 family, shows only ab...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Vanden Haesevelde M,Decourt JL,De Leys RJ,Vanderborght B,van der Groen G,van Heuverswijn H,Saman E

    更新日期:1994-03-01 00:00:00

  • Th-cytotoxic T-lymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector CD8+ Tc1 responses and protect against ocular infection.

    abstract::Molecularly defined vaccine formulations capable of inducing antiviral CD8+ T-cell-specific immunity in a manner compatible with human delivery are limited. Few molecules achieve this target without the support of an appropriate immunological adjuvant. In this study, we investigate the potential of totally synthetic p...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Zhang X,Issagholian A,Berg EA,Fishman JB,Nesburn AB,BenMohamed L

    更新日期:2005-12-01 00:00:00

  • Identification of a New Benzimidazole Derivative as an Antiviral against Hepatitis C Virus.

    abstract:UNLABELLED:Aminoquinolines and piperazines, linked or not, have been used successfully to treat malaria, and some molecules of this family also exhibit antiviral properties. Here we tested several derivatives of 4-aminoquinolines and piperazines for their activity against hepatitis C virus (HCV). We screened 11 molecul...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Vausselin T,Séron K,Lavie M,Mesalam AA,Lemasson M,Belouzard S,Fénéant L,Danneels A,Rouillé Y,Cocquerel L,Foquet L,Rosenberg AR,Wychowski C,Meuleman P,Melnyk P,Dubuisson J

    更新日期:2016-09-12 00:00:00

  • A novel sequence-specific DNA-binding protein, LCP-1, interacts with single-stranded DNA and differentially regulates early gene expression of the human neurotropic JC virus.

    abstract::We have identified a novel brain-derived single-stranded-DNA-binding protein that interacts with a region of the human neurotropic JC virus enhancer designated the lytic control element (LCE). This nuclear factor, LCP-1 (for lytic control element-binding protein 1), specifically recognizes the LCE, as determined by ge...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Tada H,Khalili K

    更新日期:1992-12-01 00:00:00

  • A Ty1 reverse transcriptase active-site aspartate mutation blocks transposition but not polymerization.

    abstract::Reverse transcriptases (RTs) are found in a wide variety of mobile genetic elements including viruses, retrotransposons, and infectious organellar introns. An invariant triad of aspartates is thought to be required for the catalytic function of RTs. We generated RT mutants in the yeast retrotransposon Ty1, changing ea...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Uzun O,Gabriel A

    更新日期:2001-07-01 00:00:00

  • Development of an Alternative Modified Live Influenza B Virus Vaccine.

    abstract::Influenza B virus (IBV) is considered a major human pathogen, responsible for seasonal epidemics of acute respiratory illness. Two antigenically distinct IBV hemagglutinin (HA) lineages cocirculate worldwide with little cross-reactivity. Live attenuated influenza virus (LAIV) vaccines have been shown to provide better...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Santos JJS,Finch C,Sutton T,Obadan A,Aguirre I,Wan Z,Lopez D,Geiger G,Gonzalez-Reiche AS,Ferreri L,Perez DR

    更新日期:2017-05-26 00:00:00

  • Evaluation of genetically engineered derivatives of a Chinese strain of foot-and-mouth disease virus reveals a novel cell-binding site which functions in cell culture and in animals.

    abstract::Adaptation of field isolates of foot-and-mouth disease virus (FMDV) to grow in cells in culture can result in changes in viral properties that include acquisition of the ability to bind to cell surface heparan sulfate (HS). After 13 passages on BHK cells to produce a vaccine, a Cathay topotype isolate of FMDV serotype...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Zhao Q,Pacheco JM,Mason PW

    更新日期:2003-03-01 00:00:00

  • Endoribonuclease activity associated with animal RNA viruses.

    abstract::A specific endoribonucleolytic activity was detected when detergent-lysed vesicular stomatitis of Sendai virus was incubated with the precursor to Escherichia coli tRNA Tyr. The cleavage products produced and the characteristics of the reaction were similar to those previously reported for human KB cell RNase NU. Like...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Kolakofsky D,Altman S

    更新日期:1978-01-01 00:00:00