Abstract:
PURPOSE OF REVIEW:Several gastrointestinal diseases including the inflammatory bowel diseases (IBDs) and malignancy are associated with elevated expression of indoleamine 2,3 dioxygenase-1 (IDO1). IDO1 initiates tryptophan catabolism along a pathway that generates several bioactive kynurenine-based metabolites. Promotion of T-cell-mediated tolerance and antimicrobial effects are among the variety of functions attributed to IDO1 activity. Recent advances addressing the diverse implications of gut-associated IDO1 expression are herein reviewed. RECENT FINDINGS:In active IBD, IDO1 is highly expressed both in the cells of the lamina propria and epithelium. Experimental models demonstrate that IDO1 promotes gut immune homeostasis by limiting inflammatory responses and protecting the epithelium. In human colon cancer, high expression of IDO1 by the neoplastic epithelium correlates with poor prognosis. The serum kynurenine : tryptophan ratio is elevated in both active Crohn's disease and in colon cancer, suggesting this measurement may prove useful as a disease biomarker. IDO1 inhibitors have moved to clinical trials providing new hope as immunotherapy for advanced malignancy. SUMMARY:IDO1 activity significantly shapes gastrointestinal disease pathophysiology and severity. Measures of IDO1 activity may be useful as a disease biomarker. Manipulation of IDO1 activity has great potential as a treatment for both inflammatory and malignancy associated gastrointestinal disease.
journal_name
Curr Opin Gastroenteroljournal_title
Current opinion in gastroenterologyauthors
Ciorba MAdoi
10.1097/MOG.0b013e32835c9cb3subject
Has Abstractpub_date
2013-03-01 00:00:00pages
146-52issue
2eissn
0267-1379issn
1531-7056journal_volume
29pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:This article highlights recent advances in viral hepatitis published from December 2003 to November 2004. Studies reporting novel and clinically relevant findings were selected after a PubMed search. The aim is to provide an up-to-date summary of important developments in viral hepatitis. RECENT FIND...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/01.mog.0000158109.13722.36
更新日期:2005-05-01 00:00:00
abstract:PURPOSE OF REVIEW:One of the significant limitations to the investigation of inflammatory bowel disease (IBD) in humans is the impossibility of studying this condition from the beginning of the disease process to understand the individual contribution of the various microbiological and immunological components to its p...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e32832b36eb
更新日期:2009-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize published research on pancreatic surgery over the past year. RECENT FINDINGS:Improvements in the treatment of patients with acute gallstone pancreatitis with regards to the timing of ERCP and cholecystectomy as well as management of pancreatic pseudocysts have been reported. It is often ...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e32833d1174
更新日期:2010-09-01 00:00:00
abstract::Over the last year, several interesting studies have been published on the treatment of esophageal carcinoma. Surprisingly, none of them was a randomized phase III trial. The debate on the necessary extent of a potentially curative surgical resection is ongoing. After initially disappointing results, the innovative te...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200107000-00017
更新日期:2001-07-01 00:00:00
abstract::The development of small bowel transplantation has long been hindered by the immunological and infectious barriers peculiar to the small bowel. Gradual progress has been achieved during the past decade with the use of tacrolimus and the availability of better anti-infection prophylaxis. The current status of small bow...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200003000-00006
更新日期:2000-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Eosinophilic colitis is a rare condition, with a prevalence rate in the USA of 2-3/100 000 persons (0.003%), but diagnosed in 0.1% of biopsies in those colonoscoped for diarrhoea. Secondary colonic eosinophilia is more common and associated with systemic, colonic and infectious diseases. In this revie...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000492
更新日期:2019-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Enteral nutrition is now the preferred route of nutritional support in malnourished and ICU patients. Studies providing evidence of its efficacy, techniques of administration, and outcome are appearing daily in the literature. This review presents the most important publications in this area and criti...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,收录出版
doi:10.1097/00001574-200403000-00010
更新日期:2004-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Our objective was to review advances in bile acids in health and disease published in the last 2 years. Bile acid diarrhea (BAD) is recognized as a common cause of chronic diarrhea, and its recognition has been facilitated by development of new screening tests. RECENT FINDINGS:Primary BAD can account...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000344
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The 'Final Rule,' issued by the Health Resources and Service Administration in 2000, mandated that liver allocation policy should be based on disease severity and probability of death, and - among other factors - should be independent of a candidate's residence or listing. As a result, the Organ Procu...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000434
更新日期:2018-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Complicated intra-abdominal infections (cIAIs) are associated with significant morbidity and mortality. Clinical trials should help guide and improve the management of cIAIs. However, inappropriate selection or measurement of outcomes in cIAIs clinical trials can lead to misleading results on the effe...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/MOG.0000000000000591
更新日期:2020-01-01 00:00:00
abstract:PURPOSE OF REVIEW:It is now over 8 years since small bowel capsule endoscopy (SBCE) was first introduced to the gastrointestinal community. The original capsule (Given Imaging, YoKneam, Israel) - a disposable 26 x 11 mm video capsule containing its own optical dome, light source, batteries, transmitter and antenna - is...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e328334df17
更新日期:2010-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review summarizes the last year's literature regarding the regulation and measurement of gastric exocrine and endocrine secretion. RECENT FINDINGS:Parietal cells, distributed along much of the length of the oxyntic glands, with highest density in the neck and base, secrete HCl as well as transfo...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e328331b62a
更新日期:2009-11-01 00:00:00
abstract::Complementary and alternative medicine (CAM) is becoming increasingly utilized as a form of health care, with recent studies suggesting that over 40% of Americans use some form of CAM. This has major financial implications for the health care industry. Traditional physicians frequently are unaware of CAM use by their ...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200003000-00016
更新日期:2000-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The 2009 review on small intestinal ion transport, in this series, focused on recent advances in duodenal bicarbonate secretion, the importance of scaffolding proteins and the pathophysiology of inflammation-associated diarrhea. The current review focuses on advances in ion-coupled solute transport, t...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e3283358a45
更新日期:2010-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The molecular biology revolution has led to a significant improvement in our understanding of biological and physiological processes. Such expansion of knowledge has also covered the field of intestinal absorption of water-soluble vitamins and is the subject of this review. RECENT FINDINGS:Impressive...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/01.mog.0000203870.22706.52
更新日期:2006-03-01 00:00:00
abstract::Diarrhea is a common sequela of deregulated immune pathways underlying the wide range of intestinal acute and chronic diseases. The ongoing investigation of novel immune components and susceptibility factors allows better understanding of these pathologic mechanisms and continues to advance therapeutic options. ...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200211000-00010
更新日期:2002-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To quantify antiplatelet-related gastrointestinal bleeding (GIB), characterize patients at greatest risk and summarize risk-management strategies emphasizing evolving knowledge in acute management of antiplatelet-related bleeding. RECENT FINDINGS:New paradigms for acute management of antiplatelet-rel...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000394
更新日期:2017-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Hereditary liver diseases resulting in copper and iron overload may cause significant morbidity and mortality if not diagnosed and treated early. The goal of this review is to highlight the key publications on genetics, diagnosis and management of hemochromatosis and Wilson disease over the past 18 mo...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e3283521d82
更新日期:2012-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Complex physiological mechanisms have evolved to control food intake in mammals, which in health ensure the relative stability of body weight in adults. Central brain centres, gut-derived peptides and adipose-derived signals result in an integrative response to defend against starvation. Enteroendocri...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/01.mog.0000245537.43142.63
更新日期:2006-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The intestinal microbiota plays a central role in inflammatory diseases of the gut. Although most investigations regarding how the mucosal immune system interacts with the microbiota have focused on bacteria, recent studies are elucidating the additional role of commensal fungi in health and disease i...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000483
更新日期:2018-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Rotavirus infection is the leading cause of severe dehydrating gastroenteritis, responsible for an estimated 440,000 deaths per year in children less than 5 years of age worldwide. There was great optimism when the first rotavirus vaccine was licensed in the United States in July 1998 (rhesus rotaviru...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Exciting new developments and applications of imaging techniques in pancreatic diseases have emerged. This review discusses these new advances and how they are improving our ability to diagnose malignancies and inflammatory lesions, to grade severity of pancreatitis, and to stage pancreatic cancer acc...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/01.mog.0000174223.74783.1b
更新日期:2005-09-01 00:00:00
abstract::The neurohormonal control of pancreatic exocrine secretion is a complex interaction of multiple pathways involving a large number of gut hormones, neurotransmitters, and neuropeptides. Recent studies have elucidated a role for cholecystokinin in the regulation of bicarbonate and fluid secretion from pancreatic duct ce...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200209000-00003
更新日期:2002-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Even though recent accumulated data can help to understand fundamental molecular mechanisms of progression of cholangiocarcinoma (CCA), its incidence and mortality still keep increasing worldwide with poor prognosis. As appropriate animal disease models are critical to fill the gap between the finding...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e32835d6a3e
更新日期:2013-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The past few years have seen an increase in the number of research and clinical groups around the world using high-resolution manometry (HRM) to record contractile activity in the anorectum and colon. Yet despite the uptake and growing number of publications, the clinical utility and potential advanta...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000229
更新日期:2016-01-01 00:00:00
abstract:PURPOSE OF REVIEW:We critically analyze existing endoscopy-based interventions for gastroesophageal reflux disease (GERD). The focus is on the effectiveness of available procedures and to delineate goals for future research. RECENT FINDINGS:Recent evaluations of the EndoCinch system reveal poor long-term results and n...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e32832ad8b4
更新日期:2009-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an update of the advantages of new-generation molecular diagnostics as regards acute diarrhea, and to evaluate how they can help clinicians and researchers diagnose this condition. RECENT FINDINGS:Thanks to real-time polymerase chain reaction techniques, many enteropathogens can now be ide...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e3283413750
更新日期:2011-01-01 00:00:00
abstract::Interesting advances occurred recently in nutrient absorption. Kinetics of triacylglycerol appearance in endoplasmic reticulum, Golgi apparatus, and lymph support the hypothesis that endoplasmic reticulum-to-Golgi transport is rate-limiting for lipid absorption. Apolipoprotein B does not appear necessary for initial f...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-199903000-00005
更新日期:1999-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Cytokines of the intestinal microenvironment largely dictate immunological responses after mucosal insults and the dominance of homeostatic or proinflammatory pathways. This review presents important recent studies on the role of specific cytokines in the pathogenesis of intestinal inflammation. RECE...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000315
更新日期:2016-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To examine recent advances in the techniques and technologies of endoscopic resection of early gastric cancer. RECENT FINDINGS:Endoscopic mucosal resection of early gastric cancer with no risk of lymph node metastasis has been a standard technique in Japan and is increasingly becoming accepted and re...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/01.mog.0000239873.06243.00
更新日期:2006-09-01 00:00:00