Nutrient absorption.

Abstract:

:Interesting advances occurred recently in nutrient absorption. Kinetics of triacylglycerol appearance in endoplasmic reticulum, Golgi apparatus, and lymph support the hypothesis that endoplasmic reticulum-to-Golgi transport is rate-limiting for lipid absorption. Apolipoprotein B does not appear necessary for initial formation of chylomicron-sized lipid particles in the endoplasmic reticulum, but rather for their movement out of the endoplasmic reticulum and to the Golgi. If peptides are protected from luminal proteolysis by fatty acylation, or if a nonpeptide drug, acyclovir, is esterified with valine to enhance bioavailability, the peptides nevertheless are absorbed by peptide transporters. Experimental conditions needed to use human ileal mucosa for in vitro absorption studies are described. Intestinal mucosa contains leptin receptors, and leptin inhibits galactose absorption, suggesting a new site for leptin's modulation of body mass. The enhancer element for the apoB gene is located much farther from its structural gene in the intestine than in the liver.

authors

Nutting DF,Kumar NS,St Hilaire RJ,Mansbach CM 2nd

doi

10.1097/00001574-199903000-00005

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

113-9

issue

2

eissn

0267-1379

issn

1531-7056

pii

00001574-199903000-00005

journal_volume

15

pub_type

杂志文章
  • Intestinal absorption of water-soluble vitamins: an update.

    abstract:PURPOSE OF REVIEW:The molecular biology revolution has led to a significant improvement in our understanding of biological and physiological processes. Such expansion of knowledge has also covered the field of intestinal absorption of water-soluble vitamins and is the subject of this review. RECENT FINDINGS:Impressive...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000203870.22706.52

    authors: Said HM,Mohammed ZM

    更新日期:2006-03-01 00:00:00

  • Diagnosis: gastric intestinal metaplasia - what to do next?

    abstract:PURPOSE OF REVIEW:One of the most vexing problems for gastroenterologists is what actions to take after receiving a histological diagnosis of gastric intestinal metaplasia. We approach the problem by starting with suggesting a biopsy protocol that ensures obtaining the biopsies required for diagnosis, assessing the sta...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000576

    authors: Graham DY,Rugge M,Genta RM

    更新日期:2019-11-01 00:00:00

  • Inflammation in acute and chronic pancreatitis.

    abstract:PURPOSE OF REVIEW:This report reviews recent animal model and human studies associated with inflammatory responses in acute and chronic pancreatitis. RECENT FINDINGS:Animal model and limited human acute and chronic pancreatitis studies unravel the dynamic nature of the inflammatory processes and the ability of the imm...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000195

    authors: Habtezion A

    更新日期:2015-09-01 00:00:00

  • Small bowel ulcers: when is it not inflammatory bowel disease ?

    abstract:PURPOSE OF REVIEW:Increasing use of small bowel endoscopy unravels ulcers in a relevant number of patients. Although often attributed to inflammatory bowel disease (IBD), these ulcers may be unspecific or caused by a variety of other diseases. This review summarizes the recent literature related to differential diagnos...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000522

    authors: Keuchel M,Kurniawan N,Baltes P

    更新日期:2019-05-01 00:00:00

  • Endoscopic management of biliary disease.

    abstract::Endoscopic management of biliary disease remains at the forefront of minimally invasive means of providing therapy, as well as contributing important diagnostic information in complex clinical scenarios. The authors review recent advances and reported trials of therapy and revisit important controversial issues. The m...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200009000-00012

    authors: Lew RJ,Kochman ML

    更新日期:2000-09-01 00:00:00

  • Clinical applications of submucosal endoscopy.

    abstract:PURPOSE OF REVIEW:Submucosal endoscopy with mucosal flap (SEMF), a new diagnostic and therapeutic intervention of flexible endoscopy, has been examined from the perspective of developmental laboratory work, procedural details, and results of early clinical experiences. RECENT FINDINGS:Diagnostic natural orifice transl...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e328349cf8e

    authors: Sumiyama K,Gostout CJ

    更新日期:2011-09-01 00:00:00

  • Hepatic fibrosis.

    abstract:PURPOSE OF REVIEW:This review will summarize the most significant work that contributed to the understanding of liver fibrosis progression and resolution, which in turn has yielded new areas of therapeutic targeting. RECENT FINDINGS:Liver fibrosis is the result of an imbalance between production and dissolution of ext...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/mog.0b013e3283279668

    authors: Jiao J,Friedman SL,Aloman C

    更新日期:2009-05-01 00:00:00

  • Complications and surgery in the inflammatory bowel diseases biological era.

    abstract:PURPOSE OF REVIEW:Therapy for inflammatory bowel diseases (IBD) has changed dramatically in recent years with a wider use of immunomodulators and the introduction of antitumor necrosis factor (anti-TNF) agents. This article reviews the existing data on the long-term efficacy of biologics, that is, anti-TNF agents, for ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000078

    authors: Sokol H,Seksik P,Cosnes J

    更新日期:2014-07-01 00:00:00

  • Gastroduodenal mucosal defense.

    abstract:PURPOSE OF REVIEW:The gastroduodenum has multiple means by which it resists injury from intrinsic and extrinsic factors, including gastric acid, nonsteroidal anti-inflammatory drugs, and Helicobacter pylori. We review recent insights into the mechanisms by which the gastroduodenum resists injury and discuss factors con...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e328330da7b

    authors: Nayeb-Hashemi H,Kaunitz JD

    更新日期:2009-11-01 00:00:00

  • Helicobacter pylori virulence factors: facts and fantasies.

    abstract:PURPOSE OF REVIEW:Virulence factors are related to the ability of a microbe to induce disease. True virulence factors must therefore have a disease association, an in-vivo correlate with disease such as increased mucosal inflammation, or both. RECENT FINDINGS:The cytotoxin-associated gene pathogenicity island; the out...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000181711.04529.d5

    authors: Lu H,Yamaoka Y,Graham DY

    更新日期:2005-11-01 00:00:00

  • Psychological factors and weight loss in bariatric surgery.

    abstract:PURPOSE OF REVIEW:Morbid obesity is associated with a high prevalence of psychopathological conditions that might have an impact on postsurgery outcomes. This review summarizes recent data about psychological disorders in obese patients before and after bariatric surgery as well as the assessment and impact of these fa...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e3283422482

    authors: Pataky Z,Carrard I,Golay A

    更新日期:2011-03-01 00:00:00

  • Indoleamine 2,3 dioxygenase in intestinal disease.

    abstract:PURPOSE OF REVIEW:Several gastrointestinal diseases including the inflammatory bowel diseases (IBDs) and malignancy are associated with elevated expression of indoleamine 2,3 dioxygenase-1 (IDO1). IDO1 initiates tryptophan catabolism along a pathway that generates several bioactive kynurenine-based metabolites. Promoti...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32835c9cb3

    authors: Ciorba MA

    更新日期:2013-03-01 00:00:00

  • Intestinal absorption of vitamins.

    abstract::This article provides an overview of advances in understanding the cellular and molecular mechanisms and regulation of intestinal absorption processes of vitamins. The vitamins covered are the water-soluble vitamins folic acid, cobalamin (vitamin B12), biotin, pantothenic acid, and thiamine (vitamin B1) and the lipid-...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-199903000-00015

    authors: Said HM,Kumar C

    更新日期:1999-03-01 00:00:00

  • New clinical paradigms for treating and preventing antiplatelet gastrointestinal bleeding.

    abstract:PURPOSE OF REVIEW:To quantify antiplatelet-related gastrointestinal bleeding (GIB), characterize patients at greatest risk and summarize risk-management strategies emphasizing evolving knowledge in acute management of antiplatelet-related bleeding. RECENT FINDINGS:New paradigms for acute management of antiplatelet-rel...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000394

    authors: Abraham NS

    更新日期:2017-11-01 00:00:00

  • Medical management of inflammatory bowel disease: old and new perspectives.

    abstract::The treatment of inflammatory bowel disease is a continually evolving area and a major focus of the current literature in gastroenterology. As further information is gained in the areas of etiology, pathophysiology, and natural history of the disease, new agents are developed, and management strategies are revised. Th...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200107000-00007

    authors: Nash CL,Sutherland LR

    更新日期:2001-07-01 00:00:00

  • Probiotics as prevention and treatment for diarrhea.

    abstract:PURPOSE OF REVIEW:To critically appraise evidence on probiotic use for prevention and treatment of diarrhea in children and adults. RECENT FINDINGS:Several randomized controlled trials and meta-analyses suggested that probiotics are effective in primary and secondary prevention of gastroenteritis and its treatment. Se...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32831b4455

    authors: Guarino A,Lo Vecchio A,Canani RB

    更新日期:2009-01-01 00:00:00

  • Cytokines and intestinal inflammation.

    abstract:PURPOSE OF REVIEW:Cytokines of the intestinal microenvironment largely dictate immunological responses after mucosal insults and the dominance of homeostatic or proinflammatory pathways. This review presents important recent studies on the role of specific cytokines in the pathogenesis of intestinal inflammation. RECE...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000315

    authors: Bamias G,Cominelli F

    更新日期:2016-11-01 00:00:00

  • Surgery, radiotherapy, and chemotherapy for esophageal carcinoma.

    abstract::Over the last year, several interesting studies have been published on the treatment of esophageal carcinoma. Surprisingly, none of them was a randomized phase III trial. The debate on the necessary extent of a potentially curative surgical resection is ongoing. After initially disappointing results, the innovative te...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200107000-00017

    authors: van Lanschot JJ,González González D,Richel DJ

    更新日期:2001-07-01 00:00:00

  • Recent developments in antimicrobial therapy for gastrointestinal infections.

    abstract:PURPOSE OF REVIEW:This focused, narrative review summarizes human clinical trial data for direct-acting antimicrobials in development for the treatment of gastrointestinal infections that were published in the past 18 months (1 January 2019 to 30 June 2020). RECENT FINDINGS:Antimicrobial agents for Clostridioides diff...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MOG.0000000000000696

    authors: Carlson TJ,Gonzales-Luna AJ,Garey KW

    更新日期:2021-01-01 00:00:00

  • Ion transport in the small intestine.

    abstract:PURPOSE OF REVIEW:The 2009 review on small intestinal ion transport, in this series, focused on recent advances in duodenal bicarbonate secretion, the importance of scaffolding proteins and the pathophysiology of inflammation-associated diarrhea. The current review focuses on advances in ion-coupled solute transport, t...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e3283358a45

    authors: Venkatasubramanian J,Ao M,Rao MC

    更新日期:2010-03-01 00:00:00

  • Viral infections of the gastrointestinal tract.

    abstract::Viral gastroenteritis is a major public health problem worldwide, and the number of identified pathogens continuously increases. Investigators have made considerable progress toward understanding both the epidemiology and the mechanisms of virus-cell interactions, host responses, and pathogenesis. A vaccine for the mo...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200001000-00003

    authors: Shaw RD

    更新日期:2000-01-01 00:00:00

  • Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma.

    abstract:PURPOSE OF REVIEW:The aim of this brief review is to provide an up-to-date view of the role played by α-smooth muscle actin-positive cancer-associated fibroblastic cells in promoting intrahepatic cholangiocarcinoma progression. RECENT FINDINGS:An increase in α-smooth muscle actin-positive cancer-associated fibroblasti...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32834405c3

    authors: Sirica AE,Campbell DJ,Dumur CI

    更新日期:2011-05-01 00:00:00

  • Typhoid epidemiology, diagnostics and the human challenge model.

    abstract:PURPOSE OF REVIEW:Infection caused by ingestion of human-restricted Salmonella enterica serovars Typhi and Paratyphi predominantly affects the most impoverished sections of society. In this review, we describe recent advances made in estimating the burden of illness and the important role improved diagnostic tests may ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000021

    authors: Darton TC,Blohmke CJ,Pollard AJ

    更新日期:2014-01-01 00:00:00

  • New advances in pancreatic imaging.

    abstract:PURPOSE OF REVIEW:Exciting new developments and applications of imaging techniques in pancreatic diseases have emerged. This review discusses these new advances and how they are improving our ability to diagnose malignancies and inflammatory lesions, to grade severity of pancreatitis, and to stage pancreatic cancer acc...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000174223.74783.1b

    authors: Kwon RS,Brugge WR

    更新日期:2005-09-01 00:00:00

  • Primary endoscopic therapies for obesity and metabolic diseases.

    abstract:PURPOSE OF REVIEW:Endoscopic approaches to obesity may help fulfill the unmet need of over half the US adult population who would benefit from therapy for obesity but are not receiving it. Endoluminal approaches have the potential to be more efficacious than antiobesity medications and have a lower risk-cost profile co...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000203

    authors: Kumbhari V,Oberbach A,Nimgaonkar A

    更新日期:2015-09-01 00:00:00

  • Chest pain of esophageal origin.

    abstract::The treatment of patients with unexplained chest pain is difficult and challenging. After a cardiac etiology has been ruled out, a diligent search for an esophageal etiology-gastroesophageal reflux disease, motility abnormalities, or esophageal hypersensitivity-should be undertaken with judicious use of a diagnostic (...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-199907000-00013

    authors: Katz PO

    更新日期:1999-07-01 00:00:00

  • The impact of gut microbes in allergic diseases.

    abstract:PURPOSE OF REVIEW:The prevalence of allergic diseases continues to rise globally in developed countries. Since the initial proposal of the hygiene hypothesis, there has been increasing evidence to suggest that the intestinal microbiota, particularly during early infancy, plays a critical role in regulating immune respo...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e3283573017

    authors: Russell SL,Finlay BB

    更新日期:2012-11-01 00:00:00

  • Colonic and anorectal motility testing in the high-resolution era.

    abstract:PURPOSE OF REVIEW:The past few years have seen an increase in the number of research and clinical groups around the world using high-resolution manometry (HRM) to record contractile activity in the anorectum and colon. Yet despite the uptake and growing number of publications, the clinical utility and potential advanta...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000229

    authors: Dinning PG,Carrington EV,Scott SM

    更新日期:2016-01-01 00:00:00

  • Nonsteroidal anti-inflammatory drug gastrointestinal toxicity.

    abstract::Toxic effects in the upper gastrointestinal tract, primarily complicated gastric and intestinal ulcers, are the most common undesirable effects of the nonsteroidal anti-inflammatory drugs. During the last several years, there have been several advances, both in the laboratory and clinically, toward reducing nonsteroid...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200111000-00005

    authors: Cryer B

    更新日期:2001-11-01 00:00:00

  • Portal hypertension.

    abstract:PURPOSE OF REVIEW:This review discusses the advances in the pathophysiology, diagnosis, and management of the complications of portal hypertension that have occurred in the past year. RECENT FINDINGS:The specific topics reviewed are the pathophysiology of portal hypertension (including recent findings regarding intrah...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200405000-00010

    authors: Garcia-Tsao G

    更新日期:2004-05-01 00:00:00