Abstract:
PURPOSE OF REVIEW:Even though recent accumulated data can help to understand fundamental molecular mechanisms of progression of cholangiocarcinoma (CCA), its incidence and mortality still keep increasing worldwide with poor prognosis. As appropriate animal disease models are critical to fill the gap between the findings from in vitro and the applications to human diseases, lack of effective and patient-like CCA animal models may contribute to limits of controlling progression of CCA. This review is focusing to provide the information about recently developed CCA animal models. RECENT FINDINGS:Recent advancements in cell and molecular biology make it possible to mimic the pathogenicity of human CCA using various animal models. In this review, several up-to-date techniques and the examples to induce CCA in animal models (xenograft and orthotopic models, carcinogen-induced CCA model, genetically engineered mouse model for CCA) with resemblance of human CCA are discussed. SUMMARY:Not only establishing animal models relevant to CCA is beneficial for its early diagnosis and therapy but also well suited experimental CCA models will guide the development of applicable treatment strategy for the hard-to-cure CCA.
journal_name
Curr Opin Gastroenteroljournal_title
Current opinion in gastroenterologyauthors
Ko KS,Peng J,Yang Hdoi
10.1097/MOG.0b013e32835d6a3esubject
Has Abstractpub_date
2013-05-01 00:00:00pages
312-8issue
3eissn
0267-1379issn
1531-7056journal_volume
29pub_type
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/01.mog.0000194791.59337.28
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abstract:PURPOSE OF REVIEW:Human colitis-associated cancers (CAC) represent a heterogeneous group of conditions in which multiple oncogenic pathways are involved. In this article, we review the latest studies using genetic, chemical, bacterial and innate immune-mediated experimental models of CAC. RECENT FINDINGS:Using the azo...
journal_title:Current opinion in gastroenterology
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doi:10.1097/MOG.0b013e328354cc36
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abstract:PURPOSE OF REVIEW:Jaundice, the physical finding associated with hyperbilirubinemia, results when the liver is unable to properly metabolize or excrete bilirubin. The purpose of this review is to examine some of the most common causes of jaundice in adults, provide insight into the diagnostic evaluation of jaundice, an...
journal_title:Current opinion in gastroenterology
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journal_title:Current opinion in gastroenterology
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/MOG.0000000000000657
更新日期:2020-09-01 00:00:00
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journal_title:Current opinion in gastroenterology
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journal_title:Current opinion in gastroenterology
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doi:10.1097/MOG.0b013e3283422482
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e32835bdc03
更新日期:2013-03-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e328034f234
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200101000-00010
更新日期:2001-01-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200203000-00011
更新日期:2002-03-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000483
更新日期:2018-11-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,收录出版
doi:10.1097/00001574-200403000-00010
更新日期:2004-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This article describes the evolution of combination therapy in inflammatory bowel disease and how to determine when combination may not be necessary. RECENT FINDINGS:The combination of an immunosuppressive agent with an antibody to tumor necrosis factor has proven to be more effective than monotherap...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000281
更新日期:2016-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Catheter-related bloodstream infections (CRBSIs) account for a major source of morbidity in children with intestinal failure. Many of these patients require long-term central venous access, placing them at significant risk for these infections. The purpose of this review is to highlight the most curre...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e328358e268
更新日期:2013-01-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-199903000-00015
更新日期:1999-03-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200407000-00005
更新日期:2004-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Irritable bowel syndrome is a common and likely a multifactorial gastrointestinal disorder in which a disturbed brain-gut axis has been thought to have a mandatory role. Recent clinical and experimental studies imply that dietary factors may be more important in the pathogenesis of irritable bowel syn...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/01.mog.0000181712.81657.0a
更新日期:2005-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To review new advances in gastric interventional endoscopy. RECENT FINDINGS:Implementation of gastric endoscopy as a therapeutic option in obesity, gastric cancer, and gastroparesis. SUMMARY:Less invasive new gastric endoscopic procedures can potentially replace currently offered laparoscopic approa...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000397
更新日期:2017-11-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200307000-00009
更新日期:2003-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-05-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
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更新日期:2006-07-01 00:00:00
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更新日期:2009-01-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
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更新日期:2019-05-01 00:00:00
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journal_title:Current opinion in gastroenterology
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更新日期:2020-03-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
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更新日期:2014-07-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
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更新日期:2015-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-11-01 00:00:00