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Is it safe to use TNF-α blockers for systemic inflammatory disease in patients with heart failure? Importance of dosage and receptor specificity.

Abstract：

:Tumor necrosis factor-alpha (TNF-α) blockers are widely used in the treatment of chronic inflammatory diseases, especially chronic arthritis. Current guidelines advise against the use of such agents in patients who have a concomitant heart failure. Consequently, a group of patients with a devastating inflammatory disease cannot benefit from an excellent treatment option. After a critical review of the current literature, we conclude that there is not sufficient evidence to warn against such a regimen if recommended standard doses are used. A negative effect on the heart function seems to occur if unconventional high doses of TNF-α blockers are given. The theoretical background for this is discussed.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Diamantopoulos AP,Larsen AI,Omdal R

doi

10.1016/j.ijcard.2012.11.112

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

1719-23

issue

5

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(12)01625-7

journal_volume

167

pub_type

杂志文章,评审

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