Serum apelin-12 level is elevated in schoolchildren with atopic asthma.

abstract：BACKGROUND:It has been shown that interleukin (IL)-18 levels in induced sputum are reduced in asthmatic and healthy smokers. However, in chronic obstructive pulmonary disease (COPD) patients, recent data show an overproduction in the lungs and increased serum levels of IL-18, suggesting that IL-18 may be involved in th...

journal_title：Respiratory medicine

authors： Rovina N,Dima E,Gerassimou C,Kollintza A,Gratziou C,Roussos C

更新日期：2009-07-01 00:00:00

abstract：:The principals of rehabilitation medicine are to prevent muscle atrophy and improve mobility. Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with muscle atrophy and yet many patients do not undergo pulmonary rehabilitation until they have been in stable health for some time. We investigat...

journal_title：Respiratory medicine

authors： Murphy N,Bell C,Costello RW

更新日期：2005-10-01 00:00:00

abstract：INTRODUCTION:Up to 40% of patients seen in a cough clinic have unexplained chronic cough. The long term outcome of these patients is uncertain. OBJECTIVE:To determine the long-term outcome in patients diagnosed with unexplained chronic cough. METHODS:We have performed a longitudinal study of symptoms, airway inflamma...

journal_title：Respiratory medicine

authors： Yousaf N,Montinero W,Birring SS,Pavord ID

更新日期：2013-03-01 00:00:00

abstract：RATIONALE:COPD is a debilitating disease with increasing mortality worldwide. The BODE index evaluates disease severity and the St George's Respiratory Questionnaire (SGRQ) measures health status. OBJECTIVE:To identify the relationship between BODE index and the SGRQ and to test the predictive value of both tools agai...

journal_title：Respiratory medicine

authors： Marin JM,Cote CG,Diaz O,Lisboa C,Casanova C,Lopez MV,Carrizo SJ,Pinto-Plata V,Dordelly LJ,Nekach H,Celli BR

更新日期：2011-06-01 00:00:00

abstract：:Inhalation of organic dust from a swine-confinement building leads to an intense inflammatory reaction with an increased number of inflammatory cells and mediators in the upper and lower respiratory tract of previously unexposed subjects. In vitro the dust induces cytokine release from epithelial cells and alveolar ma...

journal_title：Respiratory medicine

authors： Burvall K,Palmberg L,Larsson K

更新日期：2003-01-01 00:00:00

abstract：:Pulmonary hypertension (PH) is a chronic cardiopulmonary disorder that if left untreated, progresses rapidly and is ultimately fatal. The World Health Organization (WHO) has classified PH into 5 distinct groups according to pathophysiology, hemodynamic characteristics, and clinical presentation. Dysfunction in the nit...

journal_title：Respiratory medicine

authors： Benza R,Mathai S,Nathan SD

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Video-assisted thoracoscopic surgery (VATS) is now the generally preferred surgical treatment for spontaneous pneumothorax but is more difficult once pleural adhesions have developed. To test the hypothesis that VATS is under-used because of prolonged pleural intubation, we have audited the effect of preoper...

journal_title：Respiratory medicine

authors： Waller DA,McConnell SA,Rajesh PB

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Klotho is an 'anti-ageing' hormone and transmembrane protein; Klotho deficient mice develop a similar ageing phenotype to smokers including emphysema and muscle wasting. The objective of this study was to evaluate skeletal muscle and circulating Klotho protein in smokers and COPD patients and to relate Kloth...

journal_title：Respiratory medicine

authors： Patel MS,Donaldson AV,Lewis A,Natanek SA,Lee JY,Andersson YM,Haji G,Jackson SG,Bolognese BJ,Foley JP,Podolin PL,Bruijnzeel PL,Hart N,Hopkinson NS,Man WD,Kemp PR,Polkey MI

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:In COPD patients, hyperinflation impairs cardiac function. We examined whether lung deflation improves oxygen pulse, a surrogate marker of stroke volume. METHODS:In 129 NETT patients with cardiopulmonary exercise testing (CPET) and arterial blood gases (ABG substudy), hyperinflation was assessed with residu...

journal_title：Respiratory medicine

authors： Come CE,Divo MJ,San José Estépar R,Sciurba FC,Criner GJ,Marchetti N,Scharf SM,Mosenifar Z,Make BJ,Keller CA,Minai OA,Martinez FJ,Han MK,Reilly JJ,Celli BR,Washko GR,NETT Research Group.

更新日期：2012-01-01 00:00:00

abstract：:Healthcare payers are faced with the need to allocate finite resources to maximize population health. To assist in decision-making, healthcare payers are increasingly using health outcomes information and economic analyses. Healthcare payers are often under pressure to make early decisions (around the time of product ...

journal_title：Respiratory medicine

authors： Levine M,Taylor R,Ryan M,Sculpher M

更新日期：2002-08-01 00:00:00

abstract：:The HandiHaler is a novel breath-actuated dry powder system designed for the delivery of tiotropium 18microg daily in the treatment of COPD. We compared patient ability to use the HandiHaler or metered dose inhaler (MDI) device correctly 4 weeks after receiving brief instructions and device demonstration. A single-bli...

journal_title：Respiratory medicine

authors： Dahl R,Backer V,Ollgaard B,Gerken F,Kesten S

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Asthmatic symptoms usually can be controlled with corticosteroids, but partly asthmatic patients do not respond to corticosteroids, steroid resistance (SR) play a significant role in the poorly responding. However, no approach can accurately predict steroid responsiveness in asthma patients, so prediction of...

journal_title：Respiratory medicine

authors： Jiang H,Chi X,Zhang X,Wang J

更新日期：2016-05-01 00:00:00

abstract：:The aim of the study was to investigate possible mechanisms of epithelial injury in normal subjects exposed to environmentally relevant concentrations of ozone. Fifteen healthy non-smoking subjects (M:F 12:3) were studied. Five of the 15 subjects were exposed to filtered air, six were exposed to ozone 100 parts per bi...

journal_title：Respiratory medicine

authors： Morrison D,Rahman I,MacNee W

更新日期：2006-12-01 00:00:00

abstract：:Inhalation of on-demand salbutamol (ODS) several times daily is sometimes the only beta2-agonist prescribed in moderate persistent asthma, whereas a long-acting beta2-agonist should be added. This trial aimed to compare the efficacy of formoterol dry-powder capsule 12 microg b.i.d. (Foradil) and ODS in patients with m...

journal_title：Respiratory medicine

authors： Molimard M,Bourcereau J,Le Gros V,Bourdeix I,Leynadier F,Duroux P,French FOR-F-01 Study Group.

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:Exhaled nitric oxide (FE(NO)) is a reliable non-invasive marker of airway inflammation. In 2003 FE(NO) chemiluminescence analyzer (NIOX; Aerocrine AB, Solna, Sweden) was approved by U.S. Food and Drug Administration for monitoring asthma therapy. Recently, the same company developed a portable device using...

journal_title：Respiratory medicine

authors： Pizzimenti S,Bugiani M,Piccioni P,Heffler E,Carosso A,Guida G,Rolla G

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:We aimed to investigate the natural history of non-cavitary nodular bronchiectatic (NC-NB) Mycobacterium avium complex (MAC) lung disease (LD). METHODS:Among all patients diagnosed with NC-NB MAC LD between March 2000 and December 2013, 551 patients who were followed until December 2017 were enrolled at a tert...

journal_title：Respiratory medicine

authors： Kwon BS,Lee JH,Koh Y,Kim WS,Song JW,Oh YM,Lee SD,Lee SW,Lee JS,Lim CM,Choi CM,Huh JW,Hong SB,Shim TS,Jo KW

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Patients with severe or very severe chronic obstructive pulmonary disease (COPD) frequently suffer repeated exacerbations generating high health care utilization costs. Combined corticosteroid and bronchodilator treatment using a single inhaler might - via improved compliance - reduce exacerbation rates. OB...

journal_title：Respiratory medicine

authors： Hagedorn C,Kässner F,Banik N,Ntampakas P,Fielder K

更新日期：2013-04-01 00:00:00

abstract：:Hypoxemic patients with chronic obstructive pulmonary disease (COPD) are at risk of carbon dioxide (CO(2)) retention during oxygen therapy and hypercapnia in COPD is associated with an ominous prognosis. Rebreathing with oxygen mask is possible in practice and possibly affects CO(2) retention due to an increased inspi...

journal_title：Respiratory medicine

authors： Fremault A,Silva M,Beaucage F,Berckmans D,Decramer M

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Almost all international guidelines recommend corticosteroids for management of exacerbations of chronic obstructive pulmonary disease (COPD), because it leads to improved outcomes of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Nevertheless, due to its side effects, there are still...

journal_title：Respiratory medicine

authors： Ding Z,Li X,Lu Y,Rong G,Yang R,Zhang R,Wang G,Wei X,Ye Y,Qian Z,Liu H,Zhu D,Zhou R,Zhu K,Ni R,Xia K,Luo N,Pei C

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Aspirin desensitization (AD) has been the only available modifying treatment in aspirin-exacerbated respiratory disease (AERD). The mechanisms of AD are nonetheless poorly understood. Though very effective, AD is limited by its risks and side-effects. OBJECTIVE:Moving forward to the targeted biologicals era...

journal_title：Respiratory medicine

authors： Bobolea I,Del Pozo V,Sanz V,Cabañas R,Fiandor A,Alfonso-Carrillo C,Salcedo MÁ,Heredia Revuelto R,Quirce S

更新日期：2018-10-01 00:00:00

abstract：RATIONALE:Mounting data suggest that immune cell abnormalities participate in the pathogenesis of pulmonary arterial hypertension (PAH). OBJECTIVE:To determine whether the T lymphocyte subset composition in the systemic circulation and peripheral lung is altered in PAH. METHODS:Flow cytometric analyses were performed...

journal_title：Respiratory medicine

authors： Austin ED,Rock MT,Mosse CA,Vnencak-Jones CL,Yoder SM,Robbins IM,Loyd JE,Meyrick BO

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:This study evaluated the dose-response and dosing interval of the novel long-acting muscarinic receptor antagonist (LAMA) GSK573719 in patients with COPD. METHODS:This randomized, double-blind, placebo-controlled, 3-way cross-over, incomplete block study evaluated 5 once-daily doses of GSK573719 (62.5-1000 ...

journal_title：Respiratory medicine

authors： Donohue JF,Anzueto A,Brooks J,Mehta R,Kalberg C,Crater G

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:The possible effect of the various meteorological variables on the incidence of upper and lower respiratory tract infections (RTIs) has intrigued the scientific community for decades. METHODS:We performed a retrospective analysis regarding the association between meteorological variables and clinical data fo...

journal_title：Respiratory medicine

authors： Falagas ME,Theocharis G,Spanos A,Vlara LA,Issaris EA,Panos G,Peppas G

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Limited data are available as to the relationship between computed tomography (CT) derived data on emphysema and airway wall thickness, and quality of life in subjects with chronic obstructive pulmonary disease (COPD). Such data may work to clarify the clinical correlate of the CT findings. METHODS:We inclu...

journal_title：Respiratory medicine

authors： Gietema HA,Edwards LD,Coxson HO,Bakke PS,ECLIPSE Investigators.

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:We examined the association between different adiposity indices and pulmonary function in Chinese adults in the Guangzhou Biobank Cohort Study (GBCS). METHODS:Participants with body mass index (BMI) < 18.5 (underweight) were excluded. Adiposity indices including BMI, waist circumference (WC), waist hip ratio...

journal_title：Respiratory medicine

authors： Pan J,Xu L,Lam TH,Jiang CQ,Zhang WS,Jin YL,Zhu F,Zhu T,Thomas GN,Cheng KK,Adab P

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:This study evaluated the tolerability and efficacy of inhaled AZD4818, a CCR1 antagonist, in patients with COPD. METHODS:This double-blind, placebo-controlled study (NCT00629239) randomised patients with moderate to severe COPD to AZD4818 300mug or placebo twice daily via Turbuhaler((R)) for 4 weeks. Safety,...

journal_title：Respiratory medicine

authors： Kerstjens HA,Bjermer L,Eriksson L,Dahlström K,Vestbo J

更新日期：2010-09-01 00:00:00

abstract：:The differential diagnosis of pleural masses is limited. Asbestos-related disease and invasive bronchogenic carcinoma make up the majority of cases. The diagnostic yield of biopsies is low, and invasive procedures are often required to achieve diagnosis. A variety of imaging techniques are available to help differenti...

journal_title：Respiratory medicine

authors： Bruns AS,Mastronarde JG

更新日期：2008-03-01 00:00:00

abstract：RATIONALE:Infradiagnosis of chronic obstructive pulmonary disease (COPD) may be related to the lack of knowledge about the disease and/or the scarce use of diagnostic procedures. This study analyses the frequency of respiratory symptoms and the knowledge about COPD in the general population, together with the use of sp...

journal_title：Respiratory medicine

authors： Miravitlles M,de la Roza C,Morera J,Montemayor T,Gobartt E,Martín A,Alvarez-Sala JL

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:International guidelines recommend simple spirometry for bronchiectasis patients. However, pulmonary pathophysiology of bronchiectasis is very complex and still poorly understood. Our objective was to characterize lung function in bronchiectasis and identify specific functional sub-groups. METHODS:This was ...

journal_title：Respiratory medicine

authors： Radovanovic D,Santus P,Blasi F,Sotgiu G,D'Arcangelo F,Simonetta E,Contarini M,Franceschi E,Goeminne PC,Chalmers JD,Aliberti S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Although the prevalence of chronic obstructive pulmonary disease (COPD) increases with age, no specific therapeutic approaches are available till date for the elderly population. AIM:To assess the efficacy and safety of once-daily indacaterol 150 and 300 μg in elderly patients with moderate to severe COPD. ...

journal_title：Respiratory medicine

authors： Girodet PO,Jasnot JY,Le Gros V,Decuypère L,Cao W,Devouassoux G

更新日期：2017-07-01 00:00:00