当前位置： SCI文献检索 > ARCHIVES OF ORAL BIOLOGY期刊下所有文献 > Zinc chloride exposure increases heme oxygenase-1 expression in MDPC-23 odontoblast-like cells.

Zinc chloride exposure increases heme oxygenase-1 expression in MDPC-23 odontoblast-like cells.

Abstract：

OBJECTIVE:The aim of this study is to clarify the effects of zinc chloride (ZnCl2) exposure on the induction of heme oxygenase-1 (HO-1) expression and its regulatory mechanisms in MDPC-23 mouse odontoblast-like cells. METHODS:MDPC-23 cells were incubated with ZnCl2, and the levels of HO-1 protein, phosphorylated forms of mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated protein kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38, and phosphorylated forms of amino kinase terminal (Akt) and nuclear factor-κB (NF-κB) p65 were determined with western immunoblotting. The level of HO-1 mRNA was determined with RT-PCR analysis. After pretreatment with inhibitors of ERK, JNK, p38, phosphoinositide-3 kinase (PI3K), and NF-κB, HO-1 protein level was determined in MDPC-23 cells exposed to ZnCl2. RESULTS:Following exposure to 500μM ZnCl2, the levels of both HO-1 mRNA and protein were markedly increased. The phosphorylated forms of ERK, JNK, and p38 increased after ZnCl2 exposure. Furthermore, the expression of HO-1 was markedly suppressed by treatment with the p38 inhibitor, SB203580, and mildly suppressed by the MAPK/ERK kinase inhibitor, U0126. However, treatment with the JNK inhibitor, SP600125, did not suppress ZnCl2-induced HO-1 expression. In addition, the phosphorylated forms of Akt, a downstream kinase of PI3K, and NF-κB p65 increased after ZnCl2 exposure. Treatment with the PI3K inhibitor, LY294002, and the NF-κB inhibitor, Bay11-7082, suppressed ZnCl2-induced HO-1 expression. CONCLUSION:These results suggest that ZnCl2 exposure induces HO-1 expression via multiple intracellular signalling pathways, including p38, ERK, PI3K/Akt, and NF-κB, in this odontoblast-like cell line.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Karube H,Inamura H,Matsuoka M

doi

10.1016/j.archoralbio.2012.09.002

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

355-61

issue

4

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(12)00293-2

journal_volume

58

pub_type

杂志文章

相关文献

ARCHIVES OF ORAL BIOLOGY文献大全
  • Expression of typical calpains in mouse molar.

    abstract：OBJECTIVE:Calpain is a calcium ion-dependent cysteine protease, consisting of two primary isoforms (calpain1/calpain2) which mediate crucial cellular functions. The activity of the calpains is tightly regulated by the endogenous inhibitor calpastatin. Calpains have been detected in several studies during the embryonic ...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2009.07.002

    authors： Matsunaga T,Yamamoto G,Tachikawa T

    更新日期：2009-10-01 00:00:00

  • The degradation of type I collagen and human plasma fibronectin by the trypsin-like enzyme and extracellular membrane vesicles of Bacteroides gingivalis W50.

    abstract：:A soluble trypsin-like enzyme (STE) was purified from a cell- and particle-free culture supernatant of this bacterium by a combination of ultra-centrifugation, ammonium-sulphate precipitation and gel-filtration chromatography on Sephacryl S-200. Trypsin-like activity in the culture supernatant was associated with a 58...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/0003-9969(88)90065-9

    authors： Smalley JW,Birss AJ,Shuttleworth CA

    更新日期：1988-01-01 00:00:00

  • Microvibration stimulates β-catenin expression and promotes osteogenic differentiation in osteoblasts.

    abstract：:Previous studies have demonstrated that low-magnitude, high-frequency (LMHF) mechanical vibrations (LM<1g; HF<20-90Hz) can benefit bone formation. However, the underlying mechanism is unclear. In this study, MC3T3-E1 cells were exposed to LMHF vibrations of different magnitudes to assess the effect of vibrations on β-...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2016.06.009

    authors： Zhang Y,Hou W,Liu Y,Long H,Zhang L,Zhu Z,Yu H

    更新日期：2016-10-01 00:00:00

  • Phenotype and behaviour of dental pulp cells during expansion culture.

    abstract：OBJECTIVE:Primary pulp cell cultures are frequently used to study cellular responses, odontogenic potential and stem cell responses. Their isolation and expansion via a range of technical approaches are widely reported. The purpose of this study was to investigate the influence of isolation approach and extended expans...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2009.06.008

    authors： Patel M,Smith AJ,Sloan AJ,Smith G,Cooper PR

    更新日期：2009-10-01 00:00:00

  • Dentine permeability and its role in the pathobiology of dentine sensitivity.

    abstract：:The classical hydrodynamic theory implicated fluid movement as a transducing mechanism in the production of dental sensitivity. This theory assumes that sensitive dentine must be permeable. Various measurements of dentine permeability are discussed, including: (1) factors that influence diffusive permeation across den...

    journal_title：Archives of oral biology

    pub_type： 杂志文章,评审

    doi：10.1016/0003-9969(94)90191-0

    authors： Pashley DH

    更新日期：1994-01-01 00:00:00

  • A novel p.S34N mutation of CAMP gene in patients with periodontal disease.

    abstract：OBJECTIVE:Recent studies have showed that genetic factors involved in the host responses might determine the severity of periodontitis. hCAP-18/LL-37 is a part of the innate immune response in the oral cavity. The aim of the present study was to investigate the mutation of CAMP gene encoding hCAP-18/LL-37 in the patien...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2010.11.016

    authors： Türkoğlu O,Berdeli A,Emingil G,Atilla G

    更新日期：2011-06-01 00:00:00

  • Orientation of occlusal contacts in the chimpanzee, Pan troglodytes verus, deduced from scanning electron microscopic analysis of dental microwear patterns.

    abstract：:Analysis of dental microwear may be used to detect species differences in diet and to secure information about occlusal relationships and biomechanics of the jaw. Microscratch-orientation data evaluated with reference to several hypotheses about functional, wear-related, sex and age influences on occlusal contacts ind...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/0003-9969(84)90007-4

    authors： Gordon KD

    更新日期：1984-01-01 00:00:00

  • Crevicular fluid levels of TGFbeta1 in drug-induced gingival overgrowth.

    abstract：OBJECTIVE:To determine if local, gingival crevicular fluid (GCF) levels of TGFbeta1 were altered in drug-induced gingival overgrowth. PATIENTS AND METHODS:GCF samples were collected on Periopaper strips from 45 renal transplant recipients who had been medicated with cyclosporin or cyclosporin in combination with other...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2003.09.002

    authors： Wright HJ,Chapple IL,Blair F,Matthews JB

    更新日期：2004-05-01 00:00:00

  • Gene therapy in dentistry: tool of genetic engineering. Revisited.

    abstract：:Advances in biotechnology have brought gene therapy to the forefront of medical research. The concept of transferring genes to tissues for clinical applications has been discussed nearly half a century, but the ability to manipulate genetic material via recombinant DNA technology has brought this goal to reality. The ...

    journal_title：Archives of oral biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.archoralbio.2014.11.018

    authors： Gupta K,Singh S,Garg KN

    更新日期：2015-03-01 00:00:00

  • Overexpression of TP53 mutation-associated microRNA-182 promotes tumor cell proliferation and migration in head and neck squamous cell carcinoma.

    abstract：OBJECTIVE:To investigate the functional mechanism of microRNA-182 (miR-182) in head and neck squamous cell carcinoma (HNSCC). DESIGN:HNSCC and normal samples were used to check both p53 and miR-182 expression. Two cancer cell lines with overexpression of miR-182 were used to check cell proliferation and migration. In ...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2016.09.012

    authors： Wang L,Jiang H,Li W,Jia C,Zhang H,Sun Y,Chen X,Song X

    更新日期：2017-01-01 00:00:00

  • Changes in the expression of MMP-3, MMP-9, TIMP-1 and aggrecan in the condylar cartilage of rats induced by experimentally created disordered occlusion.

    abstract：OBJECTIVE:To investigate the effects of experimentally created disordered occlusion on the mandibular condylar cartilage in terms of histological morphology and expression of MMP-3, MMP-9, TIMP-1 and aggrecan. MATERIALS AND METHODS:Eighty 8-week-old Sprague-Dawley rats were randomly divided into two experimental (Exp)...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2010.07.013

    authors： Wang GW,Wang MQ,Wang XJ,Yu SB,Liu XD,Jiao K

    更新日期：2010-11-01 00:00:00

  • Association of passive smoking with caries and related salivary biomarkers in young children.

    abstract：OBJECTIVE:To investigate the association between passive smoking, as determined by salivary cotinine level, and caries, salivary pH, buffering capacity, flow rate and microbiological counts in young children. DESIGN:Ninety passive smokers (PS) with a mean age of 5.02 years and 90 healthy age-matched controls were incl...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2008.05.007

    authors： Avşar A,Darka O,Topaloğlu B,Bek Y

    更新日期：2008-10-01 00:00:00

  • Immunocytochemical localization of fibronectin and a 165-kDa membrane protein in the odontoblast layer under initial carious lesions in man.

    abstract：:The possible role of fibronectin in dental tissue repair was investigated by comparing its distribution and that of the 165-kDa fibronectin-binding membrane protein (165 kDa-FnBP) in odontoblasts underlying carious and sound dentine. By immunoperoxidase and light microscopy, fibronectin was localized in the dentine un...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/0003-9969(95)00068-z

    authors： Farges JC,Joffre A,Lesot H,Bleicher F,Magloire H

    更新日期：1995-11-01 00:00:00

  • Oral mucosa and salivary findings in non-diabetic patients with chronic kidney disease.

    abstract：INTRODUCTION:Chronic kidney disease (CKD) and dialysis treatment could affect oral mucosa and cause qualitative or quantitative changes of saliva. OBJECTIVE:The aim of the study was to investigate oral manifestations, unstimulated salivary flow rate (USFR), salivary pH value and biochemical composition of saliva in no...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2019.04.021

    authors： Marinoski J,Bokor-Bratic M,Mitic I,Cankovic M

    更新日期：2019-06-01 00:00:00

  • Low dose propranolol decreases orthodontic movement.

    abstract：OBJECTIVE:Low dose propranolol has previously been demonstrated to suppress bone remodelling. Therefore, its effect on orthodontic movement was tested. DESIGN:Rats were assigned as follows (n=5): animals with no orthodontic appliance (G1); the remaining groups were fitted with a Ni-Ti closed-coil spring ligated to the...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2014.06.006

    authors： de Oliveira EL,Freitas FF,de Macedo CG,Clemente-Napimoga JT,Silva MB,Manhães LR Jr,Junqueira JL,Napimoga MH

    更新日期：2014-10-01 00:00:00

  • In-vitro urea-dependent pH-changes by human salivary bacteria and dispersed, artificial-mouth, bacterial plaques.

    abstract：:The pH effects of urea metabolism were studied in washed salivary-sediment bacteria from subjects that had up to 10-fold variation in oral ureolytic activity, and in dispersed artificial-mouth plaques. Adequate evaluation required analysis of the [OH-] as well as the pH curve. An initial constant rate of pH-change, la...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/0003-9969(87)90132-4

    authors： Sissons CH,Cutress TW

    更新日期：1987-01-01 00:00:00

  • Differential morphological changes in human polymorphonuclear leucocytes induced by culture products of Porphyromonas (Bacteroides) Gingivalis W50 and its colonial variants with reduced virulence.

    abstract：:The colonial variants of W50, derived after growth in a chemostat and previously designated W50/BP1, W50/BR1 and W50/BE1, produced black-, brown- and beige-pigmented colonies, respectively, and showed reductions in mouse virulence and proteolytic activity correlating with their reduced pigmentation. Incubation of glas...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/0003-9969(91)90037-u

    authors： Scragg MA,Turton LR,Williams DM

    更新日期：1991-01-01 00:00:00

  • M2-like macrophage infiltration and transforming growth factor-β secretion during socket healing process in mice.

    abstract：OBJECTIVE:Macrophages are involved in tissue inflammation and repair through cytokine secretion. However, the contribution of macrophages to healing and osteogenesis after tooth extraction remains unclear. Therefore, we investigated the distribution of osteoblastic cells and macrophages in the early healing process aft...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2021.105042

    authors： Horibe K,Hara M,Nakamura H

    更新日期：2021-01-08 00:00:00

  • Iodoform and silver-coated abutments preventing bacterial leakage through the implant-abutment interfaces: In vitro analysis using molecular-based method.

    abstract：OBJECTIVES:The aim of this in vitro study was to evaluate the effectiveness of an iodoform paste and silver-coated abutments in preventing the microbial colonization and leakage through the implant-abutment interface of morse taper and internal hexagon implants. MATERIAL AND METHODS:Seventy-two implants with morse tap...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2019.06.009

    authors： do Nascimento C,Nogueira Fernandes FHC,Teixeira W,Pedrazzi V

    更新日期：2019-09-01 00:00:00

  • Inhibition of polymorphonuclear leucocyte phagocytosis by Porphyromonas gingivalis culture products in patients with adult periodontitis.

    abstract：:Porphyromonas gingivalis culture products and a purified trypsin-like protease (TLPase) from the organism were tested for their effects on the phagocytosis of P. gingivalis by polymorphonuclear leucocytes (PMN) from 16 patients with adult periodontitis and 16 healthy subjects in a case-control study. Both the culture ...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/0003-9969(93)90134-8

    authors： Wilton JM,Hurst TJ,Scott EE

    更新日期：1993-04-01 00:00:00

  • Oral fluid proteolytic effects on histatin 5 structure and function.

    abstract：:Histatins are human salivary antifungal proteins that are prone to extensive enzymatic degradation upon their release into the oral cavity. Histatin proteolysis, leading to the disappearance of the intact protein can be expected to have functional consequences. Histatin 5, comprising 24 residues, is the smallest of th...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2006.06.005

    authors： Helmerhorst EJ,Alagl AS,Siqueira WL,Oppenheim FG

    更新日期：2006-12-01 00:00:00

  • Mechano-growth factor E peptide inhibits the differentiation and mineralization of osteoblasts.

    abstract：OBJECTIVE:To investigate the effects of mechano-growth factor E (MGF-E) peptide derived from an IGF-1 isoform on the differentiation and mineralization of osteoblasts. METHODS:MGF-E peptide corresponding to the carboxy terminal 24 amino acid peptide of human MGF was synthesized. MGF-E (1 nM) peptide was then used to t...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2011.11.016

    authors： Xin C,Bingbing Z,Yuanliang W,Chengyu X,Li Y,Moyuan D,Qin P,Yuxiao L

    更新日期：2012-06-01 00:00:00

  • Intracellular trafficking and surface expression of SS-A (Ro), SS-B (La), poly(ADP-ribose) polymerase and alpha-fodrin autoantigens during apoptosis in human salivary gland cells induced by tumour necrosis factor-alpha.

    abstract：:Autoantibodies directed against nucleic acid and protein complexes present in cell nuclei characterize autoimmune diseases and are employed in diagnosis. The mechanisms by which these autoantigens escape immunological tolerance are largely unknown, but a number of recent observations suggest that modified self-protein...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/s0003-9969(02)00025-0

    authors： McArthur C,Wang Y,Veno P,Zhang J,Fiorella R

    更新日期：2002-06-01 00:00:00

  • Salivary markers of oxidative stress in patients with oral premalignant lesions.

    abstract：:The aetiology of oral premalignant lesions is unknown. Oxidative stress is associated with inflammation and cancerogenesis. The aim of our study was to compare salivary markers of oxidative and carbonyl stress in patients with oral premalignant lesions and age-matched healthy controls. Unstimulated saliva samples were...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2012.09.003

    authors： Vlková B,Stanko P,Minárik G,Tóthová L,Szemes T,Baňasová L,Novotňáková D,Hodosy J,Celec P

    更新日期：2012-12-01 00:00:00

  • Pilocarpine-induced increases in the activity of 6-phosphofructo-2-kinase and the fructose-2,6-bisphosphate content of rat salivary glands.

    abstract：:The activity of 6-phosphofructo-1-kinase (PFK-1), an important regulatory enzyme of glycolysis, was determined after injection of the sialagogue pilocarpine. The fructose-2,6-bisphosphate content of the glands and 6-phosphofructo-2-kinase (PFK-2) activity were also measured. The increase in PFK-1 activity after piloca...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/0003-9969(92)90104-g

    authors： Nicolau J,de Souza DN,Martins HR

    更新日期：1992-01-01 00:00:00

  • The antimicrobial activity of alpha-bisabolol and tea tree oil against Solobacterium moorei, a Gram-positive bacterium associated with halitosis.

    abstract：OBJECTIVE:To investigate the antimicrobial effect of alpha-bisabolol and tea tree oil alone and in combination against the halitosis-associated Gram-positive bacillus Solobacterium moorei. DESIGN:The inhibitory activity of alpha-bisabolol and tea tree oil against the reference strain S. moorei CCUG39336 and four clini...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2012.08.001

    authors： Forrer M,Kulik EM,Filippi A,Waltimo T

    更新日期：2013-01-01 00:00:00

  • Ultrastructural duality of extracellular fibrillar components of the odontoblast layer in the mouse molar.

    abstract：:The application of detergent solutions to dissociated molar dental papillae of mice permitted precise observation of the extracellular fibrillar material in the odontoblast layer and the predentine. Two types of fibrils were identified: cross-banded fibrils of variable diameter (25-200 nm) and aperiodic microfibrils o...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/0003-9969(88)90092-1

    authors： Meyer JM,Staubli A,Ruch JV

    更新日期：1988-01-01 00:00:00

  • Increased melatonin in oral mucosal tissue of oral lichen planus (OLP) patients: A possible link between melatonin and its role in oral mucosal inflammation.

    abstract：OBJECTIVE:The existence of extra-pineal melatonin has been observed in various tissues. No prior studies of melatonin in human oral mucosal tissue under the condition of chronic inflammation have been reported. The aim of this study was to investigate the presence of melatonin in oral mucosal tissue of patients with or...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/j.archoralbio.2017.02.007

    authors： Luengtrakoon K,Wannakasemsuk W,Vichitrananda V,Klanrit P,Hormdee D,Noisombut R,Chaiyarit P

    更新日期：2017-06-01 00:00:00

  • Improved reproducibility of magnetic stimulation-evoked motor potentials in the human masseter by a new method for locating stimulation sites on the scalp.

    abstract：:In magnetic-stimulation studies where motor-evoked potentials (MEP) are measured on different occasions, accurate relocation of the stimulation site on the scalp is essential. Here a novel method of locating neural stimulation sites was tested and the reproducibility of MEPs in the human masseter assessed. The heads o...

    journal_title：Archives of oral biology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0003-9969(98)00050-8

    authors： McMillan AS,Watson C,Walshaw D,Taylor JP

    更新日期：1998-08-01 00:00:00

  • Effect of caries preventive measures in children highly infected with the bacterium Streptococcus mutans.

    abstract：:The number of Strep. mutans in saliva samples was examined in 101 13-14-year-old children, 53 in a control and 48 in the test group. All in the test group with 2.5 X 10(5) Strep. mutans per ml saliva were treated with 1 per cent chlorhexidine gel, once a day, for 14 days when the number of Strep. mutans was greatly re...

    journal_title：Archives of oral biology

    pub_type： 杂志文章

    doi：10.1016/0003-9969(82)90042-5

    authors： Zickert I,Emilson CG,Krasse B

    更新日期：1982-01-01 00:00:00