Abstract:
:Total outflow facility was determined in cynomolgus monkeys by two-level constant pressure perfusion. Topical epinephrine increased facility by 30% to 35% three to four hours after dosing, whether given as a single 600-micrograms dose or as twice daily 600-micrograms doses for three days. A single 5.5-micrograms intracameral dose of epinephrine or norepinephrine increased facility by 65% to 70% three to four hours after dosing. A single 180-micrograms topical dose of timolol or betaxolol had no effect on facility three to four hours later. Timolol pretreatment prevented the facility-increasing effect of both topical epinephrine and intracameral norepinephrine, but betaxolol pretreatment prevented neither. These findings indicate that no cumulative facility-increasing effect of epinephrine, beyond the acute (three hour) facility-increasing effect, develops within three days; there may be a facility-decreasing effect of large topical epinephrine doses on the vascular structures external to the trabecular meshwork; there is no, or only subthreshold, facility-affecting ambient beta-adrenergic tone in the meshwork; and the facility-increasing effect of both epinephrine and norepinephrine is mediated by beta 2-adrenergic receptors in the trabecular endothelium.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Robinson JC,Kaufman PLdoi
10.1016/s0002-9394(14)75985-9subject
Has Abstractpub_date
1990-02-15 00:00:00pages
189-94issue
2eissn
0002-9394issn
1879-1891pii
S0002-9394(14)75985-9journal_volume
109pub_type
杂志文章abstract::We implanted nine intraocular lenses for the aphakic correction of congenital monocular cataracts in eight children (eight eyes). During follow-up periods ranging from 18 to 50 months in six children, there were no major complications connected to the surgery. Parental cooperation with treatment for amblyopia was sati...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)77820-1
更新日期:1983-09-01 00:00:00
abstract:PURPOSE:Immune checkpoint inhibitors (ICI) targeting the programmed cell death protein 1 (PD-1), or its ligand PD-L1, are the mainstay of metastatic cancer treatment. Patients receiving these treatments may develop immune-related adverse events (irAEs). This study aimed to estimate the prevalence and describe the clini...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2019.02.012
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:To compare three phacoemulsification machines for measurement accuracy and postocclusion surge (POS) in human cadaver eyes. DESIGN:In vitro comparisons of machine accuracy and POS. METHODS:Tip vacuum and flow were compared with machine indicated vacuum and flow. All machines were placed in two human cadaver e...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2008.01.024
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:To compare the demographics and ocular characteristics, including anterior segment optical coherence tomography images and zonular instability, in eyes with a history of acute angle closure (AAC) attack and subsequent cataract surgery. DESIGN:Retrospective case-control study. METHODS:A total of 68 eyes of 56 ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2017.09.003
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To study the appearance of margins of geographic atrophy in high-resolution optical coherence tomography (OCT) images and to correlate those changes with fundus autofluorescence (FAF) imaging. DESIGN:Retrospective, observational case study. METHODS:Patients with geographic atrophy secondary to dry age-related...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2009.04.022
更新日期:2009-09-01 00:00:00
abstract::We treated 19 eyes of 16 patients who had filamentary keratitis associated with various diseases of the cornea with 5% sodium chloride eyedrops, administered three to four times daily. Filaments associated with acute or traumatic diseases of the cornea responded in all nine cases, with rapid resolution of symptoms and...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(82)90135-0
更新日期:1982-04-01 00:00:00
abstract:PURPOSE:To study the prevalence and risk factors of intraocular pressure (IOP) elevation and refractory IOP elevation after a single 4 mg intravitreal triamcinolone acetonide (IVTA) injection in a Chinese population. DESIGN:Retrospective, observational case series. METHODS:Retrospective chart review of all the patien...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2008.05.034
更新日期:2008-10-01 00:00:00
abstract::Long-term medical therapy and laser trabeculoplasty have been implicated as risk factors in the outcome of glaucoma filtration surgery. A retrospective analysis was performed of patients undergoing primary trabeculectomy during three key periods: before use of beta-blockers and laser trabeculoplasty (1975 and 1976), a...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73068-5
更新日期:1994-02-15 00:00:00
abstract:PURPOSE:To determine the safety and efficacy of AL-8309B (tandospirone) in the management of patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) and obtain standardized data on GA lesion growth progression. DESIGN:Prospective, controlled, double-masked, randomized, multicenter pha...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ajo.2015.08.024
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:To determine factors of uveal malignant melanoma that would help to predict prognosis in Japanese patients. METHODS:From 1969 to 1994, 23 eyes with uveal malignant melanoma were enucleated from 23 Japanese patients, and 16 of these patients were studied. In the 16 patients, enucleated eyes were evaluated for t...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70275-2
更新日期:1996-03-01 00:00:00
abstract:PURPOSE:To evaluate the effect of macular reticular pseudodrusen on retinal function using multiple imaging methods. DESIGN:Prospective cross-sectional study. METHODS:Thirteen eyes with reticular pseudodrusen, but without any other macular abnormality or glaucoma, and 20 normal eyes were evaluated. All subjects under...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2013.06.036
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:To report angiographically documented cystoid macula edema associated with the use of each of the three newly available ocular hypotensive lipids: unoprostone, travaprost, and bimatoprost. DESIGN:Observational case series. METHODS:Retrospective review of three patients in a clinical practice who had uncontrol...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(01)01411-8
更新日期:2002-03-01 00:00:00
abstract:PURPOSE:To describe the use of anterior segment optical coherence tomography (AS-OCT) to clarify the position and patency of aqueous shunt devices in the anterior chamber of eyes where corneal edema or tube position does not permit a satisfactory view. DESIGN:Noncomparative observational case series. METHODS:Four cas...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2007.02.023
更新日期:2007-06-01 00:00:00
abstract:PURPOSE:To evaluate the ocular surface inflammatory response to the presence of preservatives in nonselective beta-blocker eyedrops. DESIGN:Prospective, crossover, single-masked, randomized clinical study. METHODS:study population: Twenty primary open-angle glaucoma or ocular hypertensive patients were divided in two...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ajo.2004.08.028
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To evaluate the long-term outcomes of laser in situ keratomileusis (LASIK) for high myopia. DESIGN:A long-term (10 years) follow-up retrospective interventional case series study. METHODS:The study included 196 myopic eyes of 118 patients with a mean preoperative spherical equivalent of -13.95 +/- 2.79 diopte...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2007.08.035
更新日期:2008-01-01 00:00:00
abstract::We examined 13 patients referred for management of dislocated lens fragments after phacoemulsification. Ocular findings included corneal decompensation, glaucoma, inflammation, and retinal tears and detachments. Eleven of the 13 patients underwent vitrectomy with removal of lens fragments. Surgical indications include...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)76854-0
更新日期:1991-11-15 00:00:00
abstract:PURPOSE:To evaluate posterior subtenon injection of triamcinolone acetonide for refractory diabetic macular edema (DME). DESIGN:Retrospective, interventional, case series. METHODS: SETTING:Clinical practice. PATIENT POPULATION:Patients with persistent clinically significant DME involving the center of the fovea 3 o...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2004.09.038
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:To determine whether parapapillary choroidal microvasculature (PPCMv) density as measured by optical coherence tomography angiography differs between pseudoexfoliation syndrome (PXS) and pseudoexfoliation glaucoma (PXG). DESIGN:Cross-sectional study. METHODS:One hundred ninety-two eyes of 120 subjects from ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2020.12.002
更新日期:2020-12-10 00:00:00
abstract::We observed a 41-year-old man with congenital unilateral iris pigment epithelial hyperplasia associated with unilateral glaucoma, and considered the possible pathogenesis of this unique lesion and its relationship to the patient's glaucoma. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)76809-6
更新日期:1978-08-01 00:00:00
abstract:PURPOSE:To evaluate an optical coherence tomography (OCT)-guided, variable-dosing regimen with intravitreal ranibizumab for the treatment of patients with neovascular age-related macular degeneration (AMD). DESIGN:Open-label, prospective, single-center, nonrandomized, investigator-sponsored clinical study. METHODS:In...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ajo.2007.01.028
更新日期:2007-04-01 00:00:00
abstract::A controlled chemotherapy trial of trachoma was carried out in a Tunisian oasis among schoolchildren with active disease. We compared 1% tetracycline ointment (79 patients) or 1% rifampicin ointment (76 patients) with 5% boric acid ointment (79 patients). Medications were administered twice daily, six days a week, for...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/0002-9394(75)90740-0
更新日期:1975-05-01 00:00:00
abstract:PURPOSE:To compare the accuracy and speed of using the computerized MatchedFlicker software program (EyeIC Inc, Narberth, Pennsylvania, USA) to evaluate glaucomatous optic disc change against the traditional gold standard of manually examining stereoscopic disc photographs. DESIGN:A prospective evaluation of diagnosti...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2016.03.031
更新日期:2016-07-01 00:00:00
abstract::We made 344 stereoacuity determinations (Titmus Stereotest) on 321 children, ages 1 1/2 to 13 years, who had normal binocular single vision tested by other factors. The data showed a gradual improvement in stereoacuity scores with increasing age--up to age 9--when a normal stereoacuity of 40 seconds of arc was consist...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90679-0
更新日期:1975-06-01 00:00:00
abstract::A 50-year-old man who had been taking betamethasone for 20 days experienced a slight bilateral decrease in visual acuity. There were localized dark-gray atrophic lesions at the posterior pole, accompanied by a diffuse detachment of the sensory retina. The retinal vessels appeared to be normal and only minimal anterior...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(82)90526-8
更新日期:1982-03-01 00:00:00
abstract:PURPOSE:To examine the relationships of retinal vascular caliber with optic disc, macular, and retinal nerve fiber layer (RNFL) characteristics as measured with optical coherence tomography (OCT). DESIGN:Observational cross-sectional study. METHODS:This study included a subset of healthy children enrolled in the Sing...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2009.04.006
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:To determine the frequencies of medical and surgical treatments in an incidence cohort of 120 patients with Graves' ophthalmopathy. METHODS:We reviewed the community medical records and administered a follow-up questionnaire. RESULTS:Of the 120 patients, 89 (74.2%) required either no therapy or only supportiv...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70585-9
更新日期:1996-02-01 00:00:00
abstract:PURPOSE:To evaluate the percentage and risk indicators leading to retinal redetachment in HIV (human immunodeficiency virus) patients with CMV (cytomegalovirus) retinitis related retinal detachments that were repaired with silicone oil, and then subsequently underwent oil removal. DESIGN:Retrospective, noncomparative ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.04.059
更新日期:2005-11-01 00:00:00
abstract:PURPOSE:To report a patient who was initially examined with optic tract syndrome caused by a focal metastasis to the lateral geniculate body and optic tract. METHOD:Case report. RESULTS:A 44-year-old woman with metastatic breast cancer was initially examined with normal central visual acuity, afferent pupillary defec...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(99)80251-7
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:To examine the association between optic disk cupping and retinal vein occlusion (RVO). DESIGN:Prospective epidemiologic study. METHODS:setting: Population-based prospective study in Beaver Dam, Wisconsin. study population: Adults aged 43 to 86 years at baseline (n = 4926). observation procedures: Optic disk ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.12.015
更新日期:2006-05-01 00:00:00
abstract:PURPOSE:To determine whether residual hyperopia could be corrected postoperatively using the light adjustable lens technology in patients undergoing cataract surgery and light adjustable lens implantation. DESIGN:Prospective, nonrandomized clinical trial. METHODS:Fourteen eyes of 14 patients were studied. The manifes...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ajo.2008.08.039
更新日期:2009-03-01 00:00:00