Abstract：
BACKGROUND/OBJECTIVES:Colonic fermentation of dietary fiber may improve insulin sensitivity by the metabolic effects of short chain fatty acids (SCFA) in reducing free fatty acids (FFA). The main objectives of this study were to compare peripheral uptake of acetate (AC) in participants with normal (<40 pmol/l, NI) and high (≥ 40 pmol/l, HI) plasma insulin, and the ability of AC to reduce FFA in both the groups. SUBJECTS/METHODS:Overnight fasted NI (n=9) and HI (n=9) participants were given an intravenous (IV) infusion of 140 mmol/l sodium acetate at three different rates over 90 min. The total amount of AC infused was 51.85 mmols. RESULTS:AC clearance in NI participants was not significantly different than that in HI participants (2.11 ± 0.23 vs 2.09 ± 0.24 ml/min). FFA fell in both the groups, but rebounded to a greater extent in NI than HI participants (time × group interaction, P=0.001). Significant correlations between insulin resistance (IR) indices (homeostasis model assessment of insulin resistance (HOMA-IR), Matsuda and insulinogenic index) vs FFA rebound during IV AC infusion were also observed. CONCLUSIONS:These findings suggest that AC uptake is similar in both the groups. Participants with lower plasma insulin and lower IR indices had a greater FFA rebound. These results support the hypothesis that increasing AC concentrations in the systemic circulation may reduce lipolysis and plasma FFA concentrations and thus improve insulin sensitivity. More in-depth studies are needed to look at the effects of SCFA on FFA metabolism in insulin-resistant participants.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Fernandes J,Vogt J,Wolever TMdoi
10.1038/ejcn.2012.98subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1029-34issue
9eissn
0954-3007issn
1476-5640pii
ejcn201298journal_volume
66pub_type
杂志文章abstract：OBJECTIVE:This study is aimed at investigating the influence of body size, body fat and sexual maturation on blood pressure (BP) in adolescents. DESIGN:A cross-sectional study. SETTING:A suburban student population of Southern Italy. SUBJECTS:One hundred ninety students attending the first and second year of a secon...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600731
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVE:To assess if alcohol drinking is a risk factor for small for gestational age (SGA) birth. METHODS:Case-control study. Cases were 555 women (mean age 31 years, range 16-43) who delivered SGA babies at the Clinica Luigi Mangiagalli and the Obstetric and Gynecology Clinic of the University of Verona. The contro...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602419
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVE:To study the effect of meal composition on pancreatic polypeptide release during modified sham feeding. DESIGN:In random order and on separate occasions, isocaloric, isothermic, isoosmotic, homogenized meals (1050 kJ; 250 kcal) either rich in fat (walnuts; 64 g fat, 7 g protein, 15 g starch per 100 g), prote...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-08-01 00:00:00
abstract：OBJECTIVE:To assess vitamin D status in women and their children aged 4-5 years in Northern Jordan during summer. DESIGN:A cross-sectional study in which 93 mother-child dyads volunteered through local community centers between June and July 2007. Anthropometric measurements were performed and information on socioecon...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2009.99
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:The cardiovascular benefit of increasing fruit and vegetable (F&V) intake following diagnosis of diabetes remains unknown. We aimed to describe how quantity and variety of F&V intake, and plasma vitamin C, change after diagnosis of type 2 diabetes and examine whether these changes are associated w...
journal_title：European journal of clinical nutrition
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doi：10.1038/ejcn.2016.180
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Flavanols may provide protection against insulin resistance, but little is known about the amounts and types of flavanols that may be efficacious. SUBJECTS/METHODS:This study was designed to determine whether cocoa flavanols, over a range of intakes, improve biomarkers of glucose regulation, infl...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/ejcn.2012.101
更新日期：2012-10-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602388
更新日期：2006-07-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600456
更新日期：1997-09-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2000-03-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600697
更新日期：1999-03-01 00:00:00
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journal_title：European journal of clinical nutrition
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doi：10.1038/sj.ejcn.1602780
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Previous research has shown, in predominantly European populations, that dietary patterns are evident early in life. However, little is known about early-life dietary patterns in Australian children. We aimed to describe dietary patterns of Australian toddlers and their associations with socio-dem...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/ejcn.2013.23
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:To examine the coherence of estimated intakes of acrylamide (AA) from foods, with hemoglobin (Hb) AA adduct levels, an objective marker of environmental AA exposure. DESIGN:A cross-sectional study. SETTING:The Malmö Diet and Cancer study, a large population-based prospective cohort (n=28 098) in the south o...
journal_title：European journal of clinical nutrition
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doi：10.1038/sj.ejcn.1602704
更新日期：2008-03-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602553
更新日期：2007-04-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602143
更新日期：2005-06-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
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doi：10.1038/ejcn.2013.34
更新日期：2013-05-01 00:00:00
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journal_title：European journal of clinical nutrition
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更新日期：2009-04-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-09-01 00:00:00
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更新日期：2009-09-01 00:00:00
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journal_title：European journal of clinical nutrition
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更新日期：2012-12-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：BACKGROUND:There is a continuing need to examine the relationship between diet quality and health in the population. The Healthy Eating Index (HEI) has been developed as a composite measure of diet quality by the US Department of Agriculture. OBJECTIVES:The first objective was to use the HEI to assess the diet quality...
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更新日期：2004-12-01 00:00:00
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更新日期：2018-04-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.210
更新日期：2017-02-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2004-07-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Recently, the role of a low-carbohydrate diet in diabetes management has generated interest with claims being made regarding its superiority over the traditional high-carbohydrate, low-fat dietary approach. This systematic review and meta-analysis evaluated the interpretation and effect of a low-c...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,meta分析
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更新日期：2018-03-01 00:00:00
