Abstract:
:Mechanical stress producing head injury is associated with Parkinson's disease, suggesting that relations with other physical hazards such as whole-body vibration (WBV) should be tested. In this study, the authors evaluated the relation between occupational exposure to WBV and Parkinson's disease. A population-based case-control study with 403 cases and 405 controls was conducted in British Columbia, Canada, between 2001 and 2008. From detailed occupational histories and published measurements, metrics of occupational WBV exposure were constructed and tested for associations with Parkinson's disease using logistic regression and adjusting for age and sex first, and then also for smoking and history of head injury. While ever being occupationally exposed to WBV was inversely associated with Parkinson's disease (odds ratio = 0.67, 95% confidence interval: 0.48, 0.94), higher intensities had consistently elevated odds ratios, with a statistically significant effect being noted for intermediate intensities when exposures were restricted to the 10 years or more prior to diagnosis. Possible mechanisms of an inverse relation between low levels of WBV exposure and Parkinson's disease could include direct protective effects or correlation with other protective effects such as exercise. Higher intensities of WBV could result in micro-injury, leading to vascular or inflammatory pathology in susceptible neurons.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Harris MA,Marion SA,Spinelli JJ,Tsui JK,Teschke Kdoi
10.1093/aje/kws017subject
Has Abstractpub_date
2012-08-15 00:00:00pages
299-307issue
4eissn
0002-9262issn
1476-6256pii
kws017journal_volume
176pub_type
杂志文章abstract::Epidemiology has a rich tradition in western New York State, beginning with the classic study by Austin Flint of a waterborne typhoid fever outbreak in North Boston in 1843. Other important investigations included the study of the Buffalo poliomyelitis epidemic of 1912, by Wade Hampton Frost, which provided a comprehe...
journal_title:American journal of epidemiology
pub_type: 历史文章,杂志文章
doi:10.1093/oxfordjournals.aje.a009215
更新日期:1997-12-01 00:00:00
abstract::The Air Pollution and Health: a European Approach (APHEA) project is a coordinated study of the short-term effects of air pollution on mortality and hospital admissions using data from 15 European cities, with a wide range of geographic, sociodemographic, climatic, and air quality patterns. The objective of this paper...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009249
更新日期:1997-07-15 00:00:00
abstract::The association of body fat distribution with single and combined site osteoarthritis was investigated using data from the US Health Examination Survey I, 1960-1962 (HES I) and the first National Health and Nutrition Examination Survey I, 1971-1975 (NHANES I). The study included 1,636 adults aged 35-79 years from HES ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115711
更新日期:1990-10-01 00:00:00
abstract::To study the role of nutrition in the association of birth size and childhood growth with development of cardiovascular disease, the authors in 2002-2004 surveyed 665 men and 790 women aged 25-42 years who had been exposed as children to a community-randomized nutrition supplementation intervention in four villages in...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwj328
更新日期:2006-12-15 00:00:00
abstract::We used full-system-estimation instrumental-variables simultaneous equations modeling (IV-SEM) to examine physical activity relative to body mass index (BMI; weight (kg)/height (m)(2)) using 25 years of data (1985/1986 to 2010/2011) from the Coronary Artery Risk Development in Young Adults (CARDIA) Study (n = 5,115; a...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kww010
更新日期:2016-09-15 00:00:00
abstract::Using data from the Women's Health Initiative (1993-2009; n = 158,833 participants, of whom 84.1% were white, 9.2% were black, 4.1% were Hispanic, and 2.6% were Asian), we compared all-cause, cardiovascular, and cancer mortality rates in white, black, Hispanic, and Asian postmenopausal women with and without diabetes....
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwt177
更新日期:2013-11-15 00:00:00
abstract::From July 1, 1980 to December 2, 1982, all individuals at autopsy at the University of Michigan Medical Center greater than or equal to 65 years of age and selected individuals less than 65 years of age were examined for neuritic plaques and neurofibrillary tangles. Sections of the hippocampal, parahippocampal tempora...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113897
更新日期:1984-09-01 00:00:00
abstract::The relationship between cataract prevalence, altitude, and sunlight hours was investigated in a large national probability sample survey of 105 sites in the Himalayan kingdom of Nepal, December 1980 through April 1981. Cataract of senile or unknown etiology was diagnosed by ophthalmologists in 873 of 30,565 full-time...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113632
更新日期:1983-08-01 00:00:00
abstract::There has been much concern among the public and veterans that specific environmental exposures incurred during the Gulf War were the cause of subsequent illness among Gulf War veterans. In this historical cohort study, the authors compared the postwar morbidity of US military personnel exposed to smoke from the 1991 ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/155.10.908
更新日期:2002-05-15 00:00:00
abstract::In November 1984, a foodborne outbreak of Norwalk gastroenteritis occurred in a K-12 public school in northern Vermont. The outbreak offered an opportunity to systematically study in detail secondary transmission rates in households. Eating salad at Tuesday's school-sponsored Thanksgiving Banquet was associated with i...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114756
更新日期:1987-12-01 00:00:00
abstract::As part of the Honolulu Heart Program studies, 4,581 men of Japanese ancestry living in Hawaii completed a psychosocial questionnaire in 1971. By 1980, 280 new cancer cases had been recorded. Among 12 items related to stressful life situations, there were no consistent associations with total or site-specific cancer i...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114027
更新日期:1985-04-01 00:00:00
abstract::During late 1977 and early 1978, 192 cases of epidemic keratoconjunctivitis occurred in a community in central Georgia. In 86 of these cases, the patient had been exposed to a single ophthalmologist's office (physician A) 3-22 days before onset of illness. Patients considered as cases were more likely to have had inva...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113064
更新日期:1981-01-01 00:00:00
abstract::The authors assessed the association between cognitive function and incidence and maintenance of overweight in preschool children. A population-based birth cohort was established in Menorca, Spain, between 1997 and 1999 (n = 482). Body mass index (weight (kg)/height (m)(2)) was measured at ages 4 years and 6 years (n ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp140
更新日期:2009-08-15 00:00:00
abstract::Increasing evidence suggests that maternal stress during pregnancy may influence pregnancy outcomes. In a nationwide Swedish study including almost 3 million births taking place during 1973-2006, we investigated whether maternal bereavement during pregnancy is associated with stillbirth risk. Through individual record...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kws383
更新日期:2013-02-01 00:00:00
abstract::Randomized clinical trials (RCTs) are usually the preferred strategy with which to generate evidence of comparative effectiveness, but conducting an RCT is not always feasible. Though observational studies and RCTs often provide comparable estimates, the questioning of observational analyses has recently intensified b...
journal_title:American journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/aje/kwr301
更新日期:2012-02-15 00:00:00
abstract::The relation of oral contraceptive (OC) use to the risk of hospitalization for myocardial infarction (MI) was evaluated among 121,964 US nurses who responded to a mail questionnaire. There were 156 women who reported having been hospitalized for MI before the menopause, and 23 (15%) were OC users at the time of the MI...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112874
更新日期:1980-01-01 00:00:00
abstract::Dosemeci et al. (Am J Epidemiol 1990; 132:746-8) gave examples in which nondifferential misclassification of exposure reversed the direction of a trend. Gilbert (Am J Epidemiol 1991; 134:440-1) proposed that these examples occurred because the errors in exposure were systematic, and she pointed out that the relation b...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117283
更新日期:1994-09-15 00:00:00
abstract::Growing knowledge about gene-disease associations will lead to new opportunities for genetic testing. Many experts predict that genetic testing will become increasingly important as a guide to prevention, clinical management, and drug treatment based on genetic susceptibilities. As part of a Human Genetic Epidemiology...
journal_title:American journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/aje/kwf055
更新日期:2002-08-15 00:00:00
abstract::Does a rise in crime result in increased sitting time and a reduction in physical activity? We used unobserved ("fixed")-effects models to examine associations between change in objectively measured crime (nondomestic violence, malicious damage, breaking and entering, and stealing, theft, and robbery) in Australia and...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kww106
更新日期:2016-12-15 00:00:00
abstract::One measure of the severity of a pandemic influenza outbreak at the individual level is the risk of death among people infected by the new virus. However, there are complications in estimating both the numerator and denominator. Regarding the numerator, statistical estimates of the excess deaths associated with influe...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kws314
更新日期:2013-04-15 00:00:00
abstract::The genes glutathione S-transferase M1 (GSTM1) (chromosome 1p13.3) and glutathione S-transferase T1 (GSTT1) (22q11.2) code for cytosolic enzymes glutathione S-transferase (GST)-mu and GST-theta, respectively, which are involved in phase 2 metabolism. Both genes may be deleted. There is geographic and ethnic variation ...
journal_title:American journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/oxfordjournals.aje.a010124
更新日期:2000-01-01 00:00:00
abstract::The authors conducted a prospective study of risk factors for intrauterine growth retardation (birth weight less than a standard (race- and sex-adjusted) 10th percentile for gestational age) and preterm birth (birth prior to 37 weeks gestation) in a high-risk, inner-city, obstetric population, with special interest in...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115244
更新日期:1989-06-01 00:00:00
abstract::Maternal concentrations of insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 1 (IGFBP-1) may influence fetal growth. Offspring birth weight related to maternal IGF-I and IGFBP-1 measured in pregnancy was studied in 368 randomly selected women without preeclampsia who delivered a singl...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwr067
更新日期:2011-07-15 00:00:00
abstract::The size of a person's social network is linked to health and longevity, but it is unclear whether the number of strong social ties or the number of weak social ties is most influential for health. We examined social network characteristics as predictors of mortality in the Finnish Public Sector Study (n = 7,617) and ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwx301
更新日期:2018-04-01 00:00:00
abstract::Although the results of cohort studies on the association between alcohol and breast cancer are rather consistent, the current evidence is based solely on North American cohorts. Therefore, this association was evaluated in the Netherlands Cohort Study on diet and cancer, conducted since 1986 among 62,573 women aged 5...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117357
更新日期:1995-05-15 00:00:00
abstract::The authors evaluated whether early enrollment affects the significance of the results and the time to completion and publication of randomized controlled trials. Seventy-seven efficacy randomized controlled trials (total enrollment, 28,992 patients) initiated by the Acquired Immunodeficiency Syndrome Clinical Trials ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/154.9.873
更新日期:2001-11-01 00:00:00
abstract::Previous studies have compared calipers for propensity score (PS) matching, but none have considered calipers for matching on the disease risk score (DRS). We used Medicare claims data to perform 3 cohort studies of medication initiators: a study of raloxifene versus alendronate in 1-year nonvertebral fracture risk, a...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwv302
更新日期:2016-05-15 00:00:00
abstract::In a case-control study, matching on a disease risk score (DRS), which includes many confounders, should theoretically result in greater precision than matching on only a few confounders; however, this has not been investigated. We simulated 1,000 hypothetical cohorts with a binary exposure, a time-to-event outcome, a...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwv269
更新日期:2016-05-15 00:00:00
abstract::Alcohol consumption is a major risk factor for cancers of the mouth and pharynx (oral cancer), but the differential risks by beverage type are unclear. In this 1992-1995 study, the authors examined oral cancer risk in Puerto Rico, comparing alcohol intake among 286 male cases aged 21-79 years and 417 population-based ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwg055
更新日期:2003-05-15 00:00:00
abstract::Observational longitudinal research is particularly useful for assessing etiology and prognosis and for providing evidence for clinical decision making. However, there are no structured reporting requirements for studies of this design to assist authors, editors, and readers. The authors developed and tested a checkli...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwi042
更新日期:2005-02-01 00:00:00