Abstract:
:Alcohol consumption is a major risk factor for cancers of the mouth and pharynx (oral cancer), but the differential risks by beverage type are unclear. In this 1992-1995 study, the authors examined oral cancer risk in Puerto Rico, comparing alcohol intake among 286 male cases aged 21-79 years and 417 population-based male controls, frequency matched by age. Heavy consumers of liquor (>/=43 drinks per week) had strongly increased risks of oral cancer (odds ratio = 6.4, 95% confidence interval: 2.4, 16.8); beer/wine showed only modest effects. Among liquor drinkers, risks were consistently greater for those who drank straight (undiluted) liquor than for those who usually drank mixed (diluted) liquor (odds ratio = 4.0, 95% confidence interval: 2.4, 6.7). Risks associated with combined exposure to tobacco were also more pronounced when subjects drank liquor straight. The elevated risks associated with drinking homemade rum were similar to those for other types of liquor. These results suggest that alcohol concentration is a risk factor for oral cancer independent of the total quantity of alcohol consumed.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Huang WY,Winn DM,Brown LM,Gridley G,Bravo-Otero E,Diehl SR,Fraumeni JF Jr,Hayes RBdoi
10.1093/aje/kwg055subject
Has Abstractpub_date
2003-05-15 00:00:00pages
881-7issue
10eissn
0002-9262issn
1476-6256journal_volume
157pub_type
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