Abstract:
:Actinomycetes are virtually unlimited sources of novel compounds with many therapeutic applications and hold a prominent position due to their diversity and proven ability to produce novel bioactive compounds. There are more than 22,000 known microbial secondary metabolites, 70% of which are produced by actinomycetes, 20% from fungi, 7% from Bacillus spp. and 1-2% by other bacteria. Among the actinomycetes, streptomycetes group are considered economically important because out of the approximately more than 10,000 known antibiotics, 50-55% are produced by this genus. The ecological role of actinomycetes in the marine ecosystem is largely neglected and various assumptions meant there was little incentive to isolate marine strains for search and discovery of new drugs. The search for and discovery of rare and new actinomycetes is of significant interest to drug discovery due to a growing need for the development of new and potent therapeutic agents. Modern molecular technologies are adding strength to the target-directed search for detection and isolation of bioactive actinomycetes, and continued development of improved cultivation methods and molecular technologies for accessing the marine environment promises to provide access to this significant new source of chemical diversity with novel/rare actinomycetes including new species of previously reported actinomycetes.
journal_name
Microbiol Resjournal_title
Microbiological researchauthors
Subramani R,Aalbersberg Wdoi
10.1016/j.micres.2012.06.005subject
Has Abstractpub_date
2012-12-20 00:00:00pages
571-80issue
10eissn
0944-5013issn
1618-0623pii
S0944-5013(12)00075-4journal_volume
167pub_type
杂志文章,评审abstract::The inhibitory effect of onion oil against the growth of various isolates of bacteria representing Gram-positive (4 isolates) and Gram-negative (4 isolates) species were studied. Results show that onion oil was highly active against all Gram-positive bacteria tested and only one isolate (Klebsiella pneumoniae) of Gram...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/S0944-5013(11)80052-2
更新日期:1995-05-01 00:00:00
abstract::Classic genome editing tools including ZFN, TALEN, and CRISPR/Cas9 rely on DNA double-strand breaks for genome editing. To prevent the potential hazard caused by double-strand breaks (DSBs), a series of single base editing tools that convert cytidine (C) to thymine (T) without DSBs have been developed extensively in m...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2019.03.007
更新日期:2019-01-01 00:00:00
abstract::The wild-type yeast Saccharomyces cerevisiae (S. cerevisiae) is able to export less than 1 percent of the protein to be secreted. The reasons for retention of most of the secretory proteins on the cell surface of S. cerevisiae are unknown. Recently, temperature-sensitive (ts) mutants of S. cerevisiae showing an overse...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1078/0944-5013-00067
更新日期:2001-01-01 00:00:00
abstract::Extracellular proteases from 8 Antarctic psychrotolerant Pseudomonas sp. strains were purified and characterised. All of them are neutral metalloproteases, have an apparent molecular mass of 45kDa, optimal activity at 40 degrees C and pH 7-9, retaining significant activity at pH 5-11. With the exception of P96-18, whi...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2004.03.001
更新日期:2004-01-01 00:00:00
abstract::Bitespiramycin (biotechnological spiramycin, Bsm) is a new 16-membered macrolide antibiotic produced by Streptomyces spiramyceticus WSJ-1 integrated exogenous genes. The gene cluster for Bsm biosynthesis consists of two parts: spiramycin biosynthetic gene cluster (92 kb) and two exogenous genes including 4"-O-isovaler...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2020.126532
更新日期:2020-11-01 00:00:00
abstract::Penicillium freii (Lund and Frisvad 1994) mutants deficient in the synthesis of xanthomegnin were isolated. In vitro translated mRNA populations from selected radiation induced mutants and naturally occurring P. freii strains not able to produce xanthomegnin were examined by 2-dimensional polyacrylamide gel electropho...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/S0944-5013(96)80026-7
更新日期:1996-08-01 00:00:00
abstract::The conditions for the sequential production of antibiotic activity by Talaromyces flavus were determined. The highest level of activity against Trypanosoma cruzi was obtained from the aqueous extract of the Czapeck's fermentative culture after 48 hours, with lysis of 97.58% of the trypomastigote forms of Trypanosoma ...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1078/0944-5013-00148
更新日期:2002-01-01 00:00:00
abstract::Application of carbonate precipitation induced by Bacillus pasteurii for improving some properties of cement has been reported. However, it is not yet successful in commercial scale due to the high cost of cultivation medium. This is the first report on the application of effluent from chicken manure bio-gas plant, a ...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2016.03.010
更新日期:2016-05-01 00:00:00
abstract::The pathogenicity of a new China variety of Metarhizium anisopliae (M. anisopliae var. dcjhyium) against the subterranean termite Odontotermes formosanus and the effect of the fungal fermented solution on hemolymph intracellular calcium were studied in laboratory. Conidia from the M. anisopliae var. dcjhyium were high...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2006.11.009
更新日期:2009-01-01 00:00:00
abstract::The pectinolytic enzyme from the solid-state culture of Rhizopus oryzae NBRC 4707 was purified to homogeneity by column chromatography on CM-Toyopearl 650 M and hydroxylapatite. The molecular weight of the enzyme was estimated by SDS-polyacrylamide gel electrophoresis to be 31,000 and was reduced to 29,700 after treat...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2004.01.001
更新日期:2004-01-01 00:00:00
abstract::The functions of two long-chain fatty acid CoA ligase genes (facl) in crude oil-degrading Geobacillus thermodenitrificans NG80-2 were characterized. Facl1 and Facl2 encoded by GTNG_0892 and GTNG_1447 were expressed in Escherichia coli and purified as His-tagged fusion proteins. Both enzymes utilized a broad range of f...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2012.05.001
更新日期:2012-12-20 00:00:00
abstract::Moderately halophilic bacteria are a kind of extreme environment microorganism that can tolerate moderate salt concentrations ranging from 0.5M to 2.5M. Here, via a metagenomic library screen, we identified four putative Na(+) transporters, designated H7-Nha, H16-Mppe, H19-Cap and H35-Mrp, from moderately halophilic c...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2012.06.004
更新日期:2013-02-22 00:00:00
abstract::The bacterium Helicobacter pylori infects more than 50% of the world population and causes several gastroduodenal diseases, including gastric cancer. Nevertheless, we still need to explore some protein interactions that may be involved in pathogenesis. MreB, an actin homolog, showed some special characteristics in pre...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2017.04.008
更新日期:2017-08-01 00:00:00
abstract::A microbial consortium reducing high level of perchlorate was developed and in a fed batch bioreactor using acetate as substrate perchlorate was reduced at 0.25 g/g vss. day. Under stable performance, the microbial community structure of the reactor was analyzed through molecular and phenotypic methods. The diversity ...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2015.04.011
更新日期:2015-08-01 00:00:00
abstract::The severe and fatal human disease, tularemia, results from infection with the Gram-negative pathogen Francisella tularensis. Identification of surface outer membrane proteins, specifically lipoproteins, has been of interest for vaccine development and understanding the initiation of disease. We sought to identify Fra...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2009.11.004
更新日期:2010-09-20 00:00:00
abstract::Salmonella enterica serovar Enteritidis (S. Enteritidis, SE) is a major cause of foodborne diseases for humans. The completeness of the O-chain antigen of Lipopolysaccharide (LPS) determines whether a S. Enteritidis strain is smooth or rough. However, genes that are involved in the synthesis of LPS and rough-smooth va...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2018.05.001
更新日期:2018-01-01 00:00:00
abstract::Lactobacillus rhamnosus DSM 14870 and Lactobacillus gasseri DSM 14869 were previously isolated from the vaginal epithelial cells (VEC) of healthy women and selected for the development of the vaginal EcoVag® probiotic capsules. EcoVag® was subsequently shown to provide long-term cure and reduce relapse of bacterial va...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2017.08.003
更新日期:2017-12-01 00:00:00
abstract::"Bryndza" is a traditional Slovak dairy product (type of soft cheese) made from sheep cheese which was ripened for 14 days. Because its manufacture, transporting and/or storing represent conditions which facilitate contamination, the effect of enterocin CCM4231 in "bryndza" was investigated with the aim to reduce the ...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1078/0944-5013-00078
更新日期:2001-01-01 00:00:00
abstract::In Salmonella Typhimurium (S. Typhimurium), lipopolysaccharide (LPS) anchored on the bacterial outer membrane is a major immune stimulus that can broadly activate immune cells and induce innate immune responses. wzxE is involved in bacterial LPS biosynthesis but has rarely been reported in Salmonella; wzxE encodes a f...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2020.126502
更新日期:2020-09-01 00:00:00
abstract::The enolase EnoA1 of Lactobacillus plantarum is here shown to interact with human plasminogen (Plg). By sequence alignment of EnoA1 with Streptococcus pneumoniae and Bifidobacterium lactis enolases, we identified BS1 and BS2 Plg-binding sites. A structure prediction of EnoA1 showed lysine residues in position 255 (BS2...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2012.10.001
更新日期:2013-02-22 00:00:00
abstract::We have cloned a laccase gene fragment isolated from a Trametes versicolor strain in Korea. It showed high similarity in nucleotide sequences when compared with other fungal laccases. TNT (2,4,6-trinitrotoluene), a widely used explosive, was transformed rapidly by T. versicolor. When TNT and its catabolic intermediate...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2005.12.001
更新日期:2006-01-01 00:00:00
abstract::In a laboratory incubation study, methane (CH4) production in two saline soils and a nonsaline soil sample was investigated under flooded conditions. Mean CH4 production was remarkable (630.86 ng CH4/g) in nonsaline alluvial soil, but low (12.97 ng CH4/g) in acid sulfate saline (Pokkali) soil which was attributed to t...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/S0944-5013(00)80035-X
更新日期:2000-09-01 00:00:00
abstract::Evaluation of plant growth promoting bacteria and the associated metabolites under saline conditions can be a potential eco-friendly remediation and productivity enhancement strategy. Salt-tolerant Pseudomonas entomophila PE3 was isolated from saline soil and screened for plant growth promoting (PGP) traits. The isola...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2020.126671
更新日期:2021-03-01 00:00:00
abstract::Annual ryegrass is a fast-growing cool-season grass broadly present in the Portuguese "montado", a typically Mediterranean agro-forestry-pastoral ecosystem. A culture-dependent approach was used to investigate natural associations of this crop with potentially beneficial bacteria, aiming to identify strains suitable f...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2013.12.010
更新日期:2014-09-01 00:00:00
abstract::Aerated lagoons are commonly used for domestic and industrial wastewater treatment due to their low cost and minimal need of operational requirements. However, little information is known regarding microbial communities that inhabit these ecosystems. In this study, a 16S-DGGE approach was used to estimate bacterial di...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2007.06.005
更新日期:2009-01-01 00:00:00
abstract::Quorum sensing (QS) systems, which depend on N-acylhomoserine lactone (AHL) signal molecules, mediate the production of virulence factors in many pathogenic microorganisms. One hundred and forty-six bacterial strains, isolated from a bivalve hatchery, were screened for their capacity to degrade five synthetic AHLs [N-...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2013.04.011
更新日期:2013-11-07 00:00:00
abstract::Araucaria angustifolia, a unique species of this genus that occurs naturally in Brazil, has a high socio-economic and environmental value and is critically endangered of extinction, since it has been submitted to intense predatory exploitation during the last century. Root-associated bacteria from A. angustifolia were...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2011.03.003
更新日期:2012-01-20 00:00:00
abstract::A marine Streptomyces sp. SNG9 was characterized by its ability to utilize poly(3-hydroxybutyrate) (PHB) and its copolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate P (3HB-co-HV). The bacterium grew efficiently in a simple mineral liquid medium enriched with 0.1 % poly(3-hydroxybutyrate) powder as the sole carbon so...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1078/0944-5013-00115
更新日期:2001-01-01 00:00:00
abstract::Staphylococcus epidermidis strains were isolated from the expressed human breast milk (EHM) of 14 healthy donor mothers. Genetic diversity was evaluated using RAPD-PCR REP-PCR and pulse-field gel electrophoresis (PFGE). PFGE allowed the best discrimination of the isolates, since it provided for the greatest diversity ...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2012.09.004
更新日期:2013-02-22 00:00:00
abstract::The present investigation reveals the solubilization efficiency of tri-calcium phosphate (TCP), Udaipur rock phosphate (URP), aluminium phosphate (AP) and ferric phosphate (FP) by Aspergillus niger (ITCC 6719) and Trichoderma harzianum (ITCC 6721) as function of carbon concentrations. Increasing glucose concentration ...
journal_title:Microbiological research
pub_type: 杂志文章
doi:10.1016/j.micres.2016.09.005
更新日期:2016-12-01 00:00:00