Metacognitive therapy in treatment-resistant depression: a platform trial.

Abstract:

:Patients with treatment-resistant depression received up to 8 sessions of metacognitive therapy (MCT) targeting attentional control, rumination, worry, and metacognitive beliefs. A baseline period was followed by weekly sessions with follow-up assessments at 6 and 12 months post treatment. Large and statistically significant improvements occurred in all symptom measures at post treatment and were maintained over follow-up. Two out of 3 process measures significantly improved at post treatment and all of these measures were improved at follow-up. Treatment was associated with similar response rates on the BDI and Hamilton rating scale. Using liberal criteria 80% of completers were classified as recovered at post treatment and 70% at follow-up on the BDI. In the intention to treat sample 66.6% were recovered at post treatment and 58.3% at follow-up. More stringent criteria showed 60% recovery rates at post treatment and at 12 m. The results suggest that MCT could be a brief and effective treatment and they provide a precedent for more definitive randomized controlled trials.

journal_name

Behav Res Ther

authors

Wells A,Fisher P,Myers S,Wheatley J,Patel T,Brewin CR

doi

10.1016/j.brat.2012.02.004

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

367-73

issue

6

eissn

0005-7967

issn

1873-622X

pii

S0005-7967(12)00031-9

journal_volume

50

pub_type

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