An ectopic stromal implant model for hematopoietic reconstitution and in vivo evaluation of bone marrow niches.

abstract：:Despite the high prevalence and devastating outcome, there remain a few options for treatment of ischemic stroke. Currently available treatments are limited by a short time window for treatment and marginal efficacy when used. We have tested a human umbilical cord blood-derived stem cell line that has been shown to re...

journal_title：Cell transplantation

authors： Hocum Stone LL,Xiao F,Rotschafer J,Nan Z,Juliano M,Sanberg CD,Sanberg PR,Kuzmin-Nichols N,Grande A,Cheeran MC,Low WC

更新日期：2016-01-01 00:00:00

abstract：:"Proof-of-principle" that cell replacement therapy works for neurodegeneration has been reported, but only using donor cells collected from fetal brain tissue obtained from surgical terminations of pregnancy. Surgical terminations of pregnancy represent an increasingly limited supply of donor cells due to the tendenc...

journal_title：Cell transplantation

authors： Kelly CM,Precious SV,Torres EM,Harrison AW,Williams D,Scherf C,Weyrauch UM,Lane EL,Allen ND,Penketh R,Amso NN,Kemp PJ,Dunnett SB,Rosser AE

更新日期：2011-01-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (MSCs) are multipotent cells characterized by their self-renewal and differentiation potential. Accumulating clinical and preclinical evidence indicate MSCs are a promising cell source for regenerative medical therapies. However, undesirable immortalization, spontaneous trans...

journal_title：Cell transplantation

authors： Furlani D,Li W,Pittermann E,Klopsch C,Wang L,Knopp A,Jungebluth P,Thedinga E,Havenstein C,Westien I,Ugurlucan M,Li RK,Ma N,Steinhoff G

更新日期：2009-01-01 00:00:00

abstract：:Potential labels for identifying embryonic raphe neurons and a clonal, neuronally differentiating, raphe-derived cell line, RN33B, in CNS transplantation studies were tested by first characterizing the labels in vitro. The labels that were tested included 4',6-diamidino-2-phenylindole hydrochloride, 1,1'-dioctadecyl-3...

journal_title：Cell transplantation

authors： Onifer SM,White LA,Whittemore SR,Holets VR

更新日期：1993-03-01 00:00:00

abstract：:The immunomodulatory characteristics of mesenchymal stromal cells (MSCs) may lead to multifaceted strategies in rejection of organ transplantation. This study was designed to investigate, first, the effect of the donor-type MSCs from Wistar rats on the immune system of immunocompetent Lewis rats and, second, the rejec...

journal_title：Cell transplantation

authors： Merino A,Ripoll E,de Ramon L,Bolaños N,Goma M,Bestard O,Lloberas N,Grinyo JM,Ambròs JT

更新日期：2017-06-09 00:00:00

abstract：:The cytology of peritoneal washing fluids for gastric cancer is the most basic method for judging peritoneal micrometastasis. However, the clinical value of this method is not clear at present. A retrospective analysis was performed on 277 patients with pathologically proven and surgically treated gastric cancer. The ...

journal_title：Cell transplantation

authors： Jiang RP,Xiong XJ,Qiu XS,Wang EH,Wu GP

更新日期：2019-11-01 00:00:00

abstract：:Previously, we found that hepatocyte growth factor receptor (c-Met)-and alpha-fetoprotein (AFP)-expressing cells were present in adult rat bone marrow, and that these cells also expressed hematopoietic stem cell markers, such as CD34, Thy-1, and c-Kit. When bone marrow cells were cultured in a hepatocyte growth medium...

journal_title：Cell transplantation

authors： Miyazaki M,Masaka T,Akiyama I,Nakashima E,Sakaguchi M,Huh NH

更新日期：2004-01-01 00:00:00

abstract：:Stem cell transplants into damaged myocardium may have the potential to improve cardiac function. We investigated the safety of transplanting unmanipulated autologous bone marrow into infarcted myocardium of patients undergoing coronary bypass surgery and assessed its efficacy to improve cardiac function. Fourteen pat...

journal_title：Cell transplantation

authors： Galiñanes M,Loubani M,Davies J,Chin D,Pasi J,Bell PR

更新日期：2004-01-01 00:00:00

abstract：:A human embryonic stem cell (HESC) line, H1, was studied after differentiation to a dopaminergic phenotype in vitro in order to carry out in vivo studies in Parkinsonian monkeys. To identify morphological characteristics of transplanted donor cells, HESCs were transfected with a GFP lentiviral vector. Gene expression ...

journal_title：Cell transplantation

authors： Wakeman DR,Weiss S,Sladek JR,Elsworth JD,Bauereis B,Leranth C,Hurley PJ,Roth RH,Redmond DE

更新日期：2014-01-01 00:00:00

abstract：:One of the serious obstacles of the aortopathies research is a considerable shortage of human aortic smooth muscle cells (SMCs), which can be used to model the disease. SMC in most cases come from the whole aorta of transplant donors, which are rather difficult to access. In the course of coronary artery bypass graft ...

journal_title：Cell transplantation

authors： Kostina D,Zverev D,Grebennik V,Gordeev M,Ignatieva E,Voronkina I,Kostareva A,Malashicheva A

更新日期：2017-10-01 00:00:00

abstract：:There has been no gold standard for intraoperative monitoring in carotid endarterectomy (CEA) till now. The purpose of the current study was to investigate the value of near-infrared spectroscopy (NIRS) monitoring in CEA and explore the thresholds for intraoperative cerebral hypoperfusion. Eighty-four consecutive pati...

journal_title：Cell transplantation

authors： Wang Y,Li L,Wang T,Zhao L,Feng H,Wang Q,Fan L,Feng X,Xiao W,Feng K

更新日期：2019-02-01 00:00:00

abstract：:Liver fibrosis is characterized by excessive accumulation of extracellular matrix components in the liver parenchyma that distorts the normal architecture and hepatic function. Progressive fibrosis could end in the advanced stage known as cirrhosis, resulting in the need to resort to liver transplantation. Amniotic me...

journal_title：Cell transplantation

authors： SantAnna LB,Hage R,Cardoso MA,Arisawa EA,Cruz MM,Parolini O,Cargnoni A,SantAnna N

更新日期：2016-12-13 00:00:00

abstract：:Cell transplantation is now being explored as a new therapeutic strategy to restore function in the diseased human central nervous system. Neural grafts show long-term survival and function in patients with Parkinson's disease but the symptomatic relief needs to be increased. Cell transplantation seems justified in pa...

journal_title：Cell transplantation

authors： Lindvall O

更新日期：1995-07-01 00:00:00

abstract：:Epithelial wound repair assures the recovery of the epithelial barrier after wounding. During wound healing epithelial cells migrate to cover the wound surface. The presented experiments were carried out to compare the migration of human keratinocytes from primary and secondary culture on polystyrene, collagen, and fi...

journal_title：Cell transplantation

authors： Drukała J,Bandura L,Cieślik K,Korohoda W

更新日期：2001-01-01 00:00:00

abstract：:This invited concise review was written for the special issue of Cell Transplantation to celebrate the 25th anniversary of the American Society for Neural Therapy and Repair (ASNTR). I aimed to present a succinct summary of two interweaved lines of research work carried out by my team members and collaborators over th...

journal_title：Cell transplantation

authors： Teng YD

更新日期：2019-04-01 00:00:00

abstract：:The ability to replace damaged myocardial tissue with new striated muscle would constitute a major advance in the treatment of diseases that irreversibly injure cardiac muscle cells. The creation of focal grafts of skeletal muscle has been reported following the intramural injection of skeletal myoblasts into both nor...

journal_title：Cell transplantation

authors： Robinson SW,Cho PW,Levitsky HI,Olson JL,Hruban RH,Acker MA,Kessler PD

更新日期：1996-01-01 00:00:00

abstract：:A large proportion of islets are lost after transplantation partly due to a lack of functional vasculature. Islets revascularize from host tissue but the process takes up to 2 weeks and has been suggested to result in reduced vascular density in engrafted islets. We describe a method for observing and quantifying the ...

journal_title：Cell transplantation

authors： Jones GL,Juszczak MT,Hughes SJ,Kooner P,Powis SH,Press M

更新日期：2007-01-01 00:00:00

abstract：:A population of Hoechst 33342-stained cells, termed side population (SP) cells, can reconstitute the hematopoietic system of syngeneic mice. This study examined whether limiting numbers of SP cells can repopulate mice across a xenogeneic MHC class I barrier. SP cells were isolated from HLA.B7 and HLA.A2.1 transgenic m...

journal_title：Cell transplantation

authors： Jackson JD,Zhou G,Kuszynski CA,Cai J,Fox IJ

更新日期：2002-01-01 00:00:00

abstract：:The anatomical specificity of axon growth from fetal pig septal xenografts was studied by transplanting septal cells from E30-35 pig fetuses into cholinergic deafferented (192-IgG-saporin-infused) rats or into aged rats (> 18 months). Cell suspensions (100,000 cells/microl) were injected bilaterally into the dorsal an...

journal_title：Cell transplantation

authors： Deacon T,Whatley B,LeBlanc C,Lin L,Isacson O

更新日期：1999-01-01 00:00:00

abstract：:Spinal cord injury (SCI) causes loss of neural functions below the level of the lesion due to interruption of spinal pathways and secondary neurodegenerative processes. The transplant of neural stem cells (NSCs) is a promising approach for the repair of SCI. Reprogramming of adult somatic cells into induced pluripoten...

journal_title：Cell transplantation

authors： López-Serrano C,Torres-Espín A,Hernández J,Alvarez-Palomo AB,Requena J,Gasull X,Edel MJ,Navarro X

更新日期：2016-10-01 00:00:00

abstract：:The main purpose of this work has been to establish a new culturing technique to improve the chondrogenic commitment of isolated adult human chondrocytes, with the aim of being used during cell-based therapies or tissue engineering strategies. By using a rather novel technique to generate scaffold-free three-dimension...

journal_title：Cell transplantation

authors： Martinez I,Elvenes J,Olsen R,Bertheussen K,Johansen O

更新日期：2008-01-01 00:00:00

abstract：:We here present an immunologic head-to-head comparison between human umbilical cord lining mesenchymal stem cells (clMSCs) and adult bone marrow MSCs (bmMSCs) from patients >65 years of age. clMSCs had significantly lower HLA class I expression, higher production of tolerogenic TGF-β and IL-10, and showed significantl...

journal_title：Cell transplantation

authors： Deuse T,Stubbendorff M,Tang-Quan K,Phillips N,Kay MA,Eiermann T,Phan TT,Volk HD,Reichenspurner H,Robbins RC,Schrepfer S

更新日期：2011-01-01 00:00:00

abstract：:The development of new cell replacement strategies using neural stem cells (NSC) may provide an alternative and unlimited cell source for clinical neural transplantation in neurodegenerative diseases such as Parkinson's and Huntington's disease. The clinical application of neural transplantation using NSC will therefo...

journal_title：Cell transplantation

authors： McLeod M,Hong M,Sen A,Sadi D,Ulalia R,Behie LA,Mendez I

更新日期：2006-01-01 00:00:00

abstract：:This study is a preliminary investigation to determine if bone marrow-derived cells, when implanted into freeze-injured urinary bladders, differentiate into smooth muscle cells and reconstruct smooth muscle layers. Bone marrow cells were harvested from femurs of male ICR mice and cultured in collagen-coated dishes for...

journal_title：Cell transplantation

authors： Imamura T,Kinebuchi Y,Ishizuka O,Seki S,Igawa Y,Nishizawa O

更新日期：2008-01-01 00:00:00

abstract：:Despite the substantial efforts to elucidate the role of early brain injury in subarachnoid hemorrhage (SAH), an effective pharmaceutical therapy for patients with SAH continues to be unavailable. This study aims to reveal the role of necroptosis after SAH, and explore whether the disruption of the blood-brain barrier...

journal_title：Cell transplantation

authors： Chen J,Jin H,Xu H,Peng Y,Jie L,Xu D,Chen L,Li T,Fan L,He P,Ying G,Gu C,Wang C,Wang L,Chen G

更新日期：2019-11-01 00:00:00

abstract：:Three-dimensional culture procedures have attracted attention in various fields of cell biology. A newly developed cell array assisted in the formation of hepatocyte spheroids by two innovations: 1) micropatterning by a hydrophilic polymer, and 2) the use of bovine carotid artery-derived HH cells as feeder cells. The ...

journal_title：Cell transplantation

authors： Miyamoto Y,Ikeya T,Enosawa S

更新日期：2009-01-01 00:00:00

abstract：:Hypoxia is an adverse condition that can jeopardize the function of a bioartificial pancreatic construct. In this study we have investigated the effects of short-term hypoxic exposure (up to 24 h) on the bioenergetic status, metabolism, and insulin secretion of perfused pancreatic constructs composed of alginate/poly-...

journal_title：Cell transplantation

authors： Papas KK,Long RC Jr,Constantinidis I,Sambanis A

更新日期：2000-05-01 00:00:00

abstract：:Natural immunological tolerance can be induced in certain types of allogeneic liver transplantation in rats. To screen for genes associated with the induction of tolerance, suppression subtractive hybridization was performed in the rat liver transplantation model between a DA donor and PVG recipient combination where ...

journal_title：Cell transplantation

authors： Zhang H,Ohmi K,Hirasawa A,Enosawa S,Hara Y,Tamura A,Tsujimoto G

更新日期：2008-01-01 00:00:00

abstract：:Liver cell transplantation into host organs like the spleen may possibly provide a temporary relief after extensive liver resection or severe liver disease or may enable treatment of an enzyme deficiency. With time, however, dedifferentiation or malignant transformation of the ectopically transplanted cells may be pos...

journal_title：Cell transplantation

authors： Lupp A,Danz M,Müller D

更新日期：2003-01-01 00:00:00

abstract：:Endostatin (ES) is a potent inhibitor of angiogenesis and tumor growth. Continuous ES delivery of ES improves the efficacy and potency of the antitumoral therapy. The TheraCyte system is a polytetrafluoroethylene (PTFE) semipermeable membrane macroencapsulation system for implantation of genetically engineered cells s...

journal_title：Cell transplantation

authors： Malavasi NV,Rodrigues DB,Chammas R,Chura-Chambi RM,Barbuto JA,Balduino K,Nonogaki S,Morganti L

更新日期：2010-01-01 00:00:00