Abstract:
OBJECTIVES:Surface modifications performed at the neck of dental implants, in the manner of micro-grooved surfaces, can reduce fibrous tissue encapsulation and prevent bacterial colonization, thereby improving fibrointegration and the formation of a biological seal. However, the applied procedures are technically complex and/or time consuming methods. The aim of this study was to analyse the fibroblast behaviour on modified titanium surfaces obtained, applying a simple and low-cost method. MATERIAL AND METHODS:An array of titanium surfaces was obtained using a commercial computerized numerical control lathe, modifying the feed rate and the cutting depth. To elucidate the potential ability of the generated surfaces to activate connective tissue cells, a thorough gene (by real time - qPCR) and protein (by western blot or zymography) expression and cellular response characterization (cell morphology, cell adhesion and cell activation by secreting extracellular matrix (ECM) components and their enzyme regulators) was performed. RESULTS:Micro-grooved surfaces have statistically significant differences in the groove's width (approximately 10, 50 and 100 μm) depending on the applied advancing fixed speed. Field emission scanning electron microscopy images showed that fibroblasts oriented along the generated grooves, but they were only entirely accommodated on the wider grooves (≥50 μm). Micro-grooved surfaces exhibited an earlier cell attachment and activation, as seen by collagen Iα1 and fibronectin deposition and activation of ECM remodelling enzymes, compared with the other surfaces. However, fibroblasts could remain in an activated state on narrower surfaces (<50 μm) at later stages. CONCLUSIONS:The use of micro-grooved surfaces could improve implant integration at the gingival site with respect to polished surfaces. Micro-grooved surfaces enhance early fibroblast adhesion and activation, which could be critical for the formation of a biological seal and finally promote tissue integration. Surfaces with wider grooves (≥50 μm) seem to be more appropriate than surfaces with narrow grooves (<50 μm), as fibroblasts could persist in an activated state on narrower grooved surfaces, increasing the probability of producing a fibrotic response.
journal_name
Clin Oral Implants Resjournal_title
Clinical oral implants researchauthors
Guillem-Marti J,Delgado L,Godoy-Gallardo M,Pegueroles M,Herrero M,Gil FJdoi
10.1111/j.1600-0501.2012.02451.xsubject
Has Abstractpub_date
2013-07-01 00:00:00pages
770-80issue
7eissn
0905-7161issn
1600-0501journal_volume
24pub_type
杂志文章abstract:OBJECTIVE:To evaluate the influence of the crown-to-implant ratio (C/I) ratio and different implant prosthetic treatment modalities on crestal bone loss around dental implants placed in the posterior region. MATERIAL AND METHODS:A total of 192 ITI dental implants were consecutively placed in premolars and molars of 83...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0501.2006.01307.x
更新日期:2007-12-01 00:00:00
abstract:AIMS:To determine whether endoscope-guided sinus elevation procedures can be consistently used to create sufficient bone support for stable implant placement and long-term implant success. MATERIAL AND METHODS:Sixty-two implants were surgically placed into 30 patients (14 men and 16 women) following internal sinus ele...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01561.x
更新日期:2008-11-01 00:00:00
abstract::The study aimed to examine the relationship between the subgingival flora around implants and their periodontal parameters. Plaque samples from 561 implants (279 patients) were analyzed by means of differential phase contrast microscopy and compared with the sample site's probing depth, bleeding tendency on probing, a...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1995.060401.x
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVES:To evaluate the effect of enamel matrix derivative in liquid form (EMD-liquid) as adjunct to grafting with natural bovine bone (NBB), on new bone formation and osseointegration in buccal dehiscence defects at dental implants. MATERIAL AND METHODS:In six beagles, 3 months after extraction of the mandibular p...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13512
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:Long-term success of dental implants depends on healthy peri-implant soft tissues and adequate bone levels. This prospective study aims to assess bone level changes around implants with internal conical connection and platform-switching abutments in the posterior mandible. MATERIAL AND METHODS:Adult patients...
journal_title:Clinical oral implants research
pub_type: 杂志文章,多中心研究
doi:10.1111/clr.12644
更新日期:2016-06-01 00:00:00
abstract::Well integrated and clinically functional titanium dental implants retrieved in humans after 14 and 40 months of settlement were used for the characterization of the interfacial area between the plasma-sprayed coating and the surrounding mineralized bone. Electron microscopic studies were performed from undecalcified ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2000.011004279.x
更新日期:2000-08-01 00:00:00
abstract:PURPOSE:The aim of this prospective clinical trial was to assess clinical, radiological, and esthetic outcomes of immediate-loaded post-extractive implants after 1 year of follow-up. MATERIALS AND METHODS:Twenty-four consecutive patients (15 females and nine males) with a mean age of 47.27 years (range 35-65) requirin...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章
doi:10.1111/clr.12403
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:This retrospective study was set to assess the influence of systemic and local bone and intra-oral factors on the occurrence of implant loss from abutment connection up to 2 years. MATERIALS AND METHODS:The files of 700 patients, have been collected randomly from the total patient group treated by means of ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01534.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:Graft consolidation follows a gradient that reflects the properties of bone substitutes at sites of sinus augmentation. Here we present an analytical method to investigate the process of graft consolidation taking the distance from the maxillary host bone into account. MATERIAL AND METHODS:We therefore evalu...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01733.x
更新日期:2009-10-01 00:00:00
abstract:AIMS/BACKGROUND:Empirically, for implant placement associated with sinus floor augmentation, a minimum of five mm of residual crestal bone height has been recommended in order to achieve sufficient initial implant stability. It has been the aim of the study to test this assumption in an experimental animal trial. MATE...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01570.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to investigate whether bone marrow aspirates (BMA) and concentrates (BMAC) influence the grafts' stability when added to deproteinized bovine bone mineral (DBBM) within the first 6 months after maxillary sinus augmentation. MATERIAL AND METHODS:26 CT data of 13 patients undergoing b...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12101
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:A systematic review and meta-analysis are carried out to assess the scientific evidence that bisphosphonate therapy can decrease the success rate of dental implants. MATERIAL AND METHODS:The PubMed (Medline) database was used to search for articles published up until February 22, 2014. The meta-analysis was ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,meta分析,评审
doi:10.1111/clr.12526
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate histologic and histomorphometric bone characteristics with a focus on vitality after lateral alveolar ridge augmentation using an autogenous bone graft as a block covered by either a platelet-rich fibrin (PRF) membrane (test group) or a standard procedure involving coverage of th...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.13605
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:Studies showing that osteoblasts exhibit a more differentiated phenotype on rough titanium (Ti) surfaces and osteoclast-resorbed bone surfaces used materials characterized by average peak to valley distance (Ra). Other surface features impacting the cells include distance between peaks, curvature of the vall...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2005.01195.x
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:We hypothesized that a biomimetic calcium phosphate (CaP) coating which incorporates morphogenetic protein 2 (BMP-2) on the deproteinized bovine bone (DBB) blocks could be used to enhance the vertical alveolar ridge augmentation for the one-stage onlay surgery with simultaneous implants insertion. We aimed to...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13558
更新日期:2020-03-01 00:00:00
abstract:AIM:The aim of this biomechanical study was to assess the influence of self-tapping blades in terms of primary implant stability between implants with self-tapping blades and implants without self-tapping blades using five different analytic methods, especially in medium-density bone. MATERIALS AND METHODS:Two differe...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.02089.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:The aim of the present study was to assess the influence of either recombinant human growth and differentiation factor 5 (rhGDF-5)- or recombinant human bone morphogenetic protein 2 (rhBMP-2)-coated natural bone mineral (NBM) on guided bone regeneration in a rat calvarial defect model. MATERIAL AND METHODS:...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01796.x
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:Guided bone regeneration (GBR) is a commonly utilized surgical technique in the craniofacial region. The transcriptional mechanisms associated with this type of bone regeneration are not well understood. The aim of this study was to characterize the transcriptome associated with GBR of a critical-size calvar...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.02104.x
更新日期:2011-04-01 00:00:00
abstract::The installation of implants directly into extraction sockets offers considerable advantages over other treatment modalities for both practitioners and patients. Usually, immediate implants are placed and subsequently covered by mucosa allowing a submerged healing mode. This report presents the rationale, clinical pro...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1994.050306.x
更新日期:1994-09-01 00:00:00
abstract:PURPOSE:The aim of this prospective study was to evaluate the soft tissue changes around implants in the aesthetic zone, placed under a trimodal approach (immediate post-extraction placement, flapless, and immediate provisional restoration) and its relationship to gingival/periodontal biotype of the patient. MATERIALS...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2012.02516.x
更新日期:2013-10-01 00:00:00
abstract::The aim of the study was to evaluate two bioresorbable polylactic acid (PLA) filler materials in a guided bone regeneration (GBR) model system. The first was Polyfibre, a fibrous PLA filler material. Polyfoam, the second material tested, consisted of a spongy PLA filler material. In each group there were eight rabbits...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1046/j.0905-7161.2003.00930.x
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the influence of the configuration of the marginal aspect of implants placed immediately into extraction sockets on peri-implant hard tissue adaptation. MATERIAL AND METHODS:In 6 Labrador dogs, endodontic treatments of the mesial roots of 1 M1 were performed and the distal roots were removed. 2 P...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12262
更新日期:2014-10-01 00:00:00
abstract:AIM:The aim of this prospective, randomized, controlled multicenter study was to determine the 3-year efficacy and stability of the soft and hard tissues at implants with a different geometry that were placed in fresh extraction sockets. MATERIAL AND METHODS:Implants with two different configurations, cylindrical (Gro...
journal_title:Clinical oral implants research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/clr.12140
更新日期:2014-03-01 00:00:00
abstract::The aim of this study was to evaluate guided bone regeneration (GBR) around dental implants placed in atrophic alveolar ridges using an experimental, nonporous bioresorbable barrier. In 8 Rhesus monkeys, the maxillary canines and lateral incisors were extracted bilaterally and the remaining alveoli were reduced to cre...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1997.080411.x
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVES:To evaluate implant survival rate, any complications, and changes in residual alveolar bone height (RABH) using saline or platelet-rich fibrin (PRF) filling after hydraulic transcrestal sinus lifting. METHODS:Dental implants were placed after hydraulic transcrestal sinus lifting and the filling of saline (2...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.13655
更新日期:2020-11-01 00:00:00
abstract:AIM:The objective of the study was to compare (i) esthetic, (ii) clinical and (iii) patient-centered outcomes following immediate (Type 1) and early implant placement (Type 2). MATERIAL AND METHODS:Thirty-eight subjects needing a single extraction (premolar to premolar) were randomly allocated to Type 1 or Type 2 impl...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12577
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this prospective study was to evaluate one-stage dental implants clinically and radiographically after 10 years in function. MATERIAL AND METHODS:Twenty-five patients with a total of 68 implants [46 hollow screws (HS) and 22 hollow cylinders (HC)] who previously participated in 5-year prospect...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2007.01479.x
更新日期:2008-03-01 00:00:00
abstract:INTRODUCTION:Despite the high success rates of endosseous oral implants, restrictions have been advocated to their placement with regard to the bone available in height and volume. The use of short or nonstandard-diameter implants could be one way to overcome this limitation. MATERIAL AND METHODS:In order to explore t...
journal_title:Clinical oral implants research
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0501.2006.01349.x
更新日期:2006-10-01 00:00:00
abstract::Although a two-stage procedure with symphyseal oral implants can lead to a long-term (15 years) 99% cumulative survival rate, a one-stage approach with immediate loading via prefabricated elements seems to offer a short-term acceptable outcome with significantly lower costs. A series of 50 consecutive patients, not el...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2004.01069.x
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVES:To analyze clinical, esthetic, radiographic, and prosthetic outcomes of implants and implant-supported reconstructions using two types of dental implants with non-matching implant abutment junctions. MATERIALS AND METHODS:A total of 64 patients in need of dental implant therapy with fixed reconstructions we...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12721
更新日期:2016-09-01 00:00:00