Enamel matrix derivative in liquid form as adjunct to natural bovine bone grafting at buccal bone dehiscence defects at implant sites: An experimental study in beagle dogs.

Abstract:

OBJECTIVES:To evaluate the effect of enamel matrix derivative in liquid form (EMD-liquid) as adjunct to grafting with natural bovine bone (NBB), on new bone formation and osseointegration in buccal dehiscence defects at dental implants. MATERIAL AND METHODS:In six beagles, 3 months after extraction of the mandibular premolars and first molars. Three titanium implants (3.3 Ø × 8.0 mm) were inserted, and dehiscence-type defects (mesiodistal width 3 mm × 5 mm depth) were created on their buccal aspect. The defects were randomly assigned to one of the following three treatment groups: Group 1: NBB, Group 2: NBB/EMD-L, Group 3: Control. All sites were covered with a collagen membrane. Histomorphometric measurements were performed after 3 months of healing. RESULTS:New bone area, bone-to-implant contact (BIC), and first BIC (fBIC) in the NBB and NBB/EMD-L groups were significantly greater than in the control group (p < .05). Further, f-BIC was at a significantly more coronal position in the NBB + EMD-liquid group (0.4 ± 0.1 mm) compared with the NBB group (1.2 ± 0.2 mm). CONCLUSIONS:Natural bovine bone grafting enhances bone regeneration and osseointegration at implants with buccal bone dehiscences compared with no grafting, and adjunct use of EMD-liquid appears to further enhance bone formation and osseointegration.

journal_name

Clin Oral Implants Res

authors

Ikawa T,Akizuki T,Shujaa Addin A,Fukuba S,Stavropoulos A,Izumi Y

doi

10.1111/clr.13512

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

989-996

issue

10

eissn

0905-7161

issn

1600-0501

journal_volume

30

pub_type

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