Enamel matrix derivative in liquid form as adjunct to natural bovine bone grafting at buccal bone dehiscence defects at implant sites: An experimental study in beagle dogs.


OBJECTIVES:To evaluate the effect of enamel matrix derivative in liquid form (EMD-liquid) as adjunct to grafting with natural bovine bone (NBB), on new bone formation and osseointegration in buccal dehiscence defects at dental implants. MATERIAL AND METHODS:In six beagles, 3 months after extraction of the mandibular premolars and first molars. Three titanium implants (3.3 Ø × 8.0 mm) were inserted, and dehiscence-type defects (mesiodistal width 3 mm × 5 mm depth) were created on their buccal aspect. The defects were randomly assigned to one of the following three treatment groups: Group 1: NBB, Group 2: NBB/EMD-L, Group 3: Control. All sites were covered with a collagen membrane. Histomorphometric measurements were performed after 3 months of healing. RESULTS:New bone area, bone-to-implant contact (BIC), and first BIC (fBIC) in the NBB and NBB/EMD-L groups were significantly greater than in the control group (p < .05). Further, f-BIC was at a significantly more coronal position in the NBB + EMD-liquid group (0.4 ± 0.1 mm) compared with the NBB group (1.2 ± 0.2 mm). CONCLUSIONS:Natural bovine bone grafting enhances bone regeneration and osseointegration at implants with buccal bone dehiscences compared with no grafting, and adjunct use of EMD-liquid appears to further enhance bone formation and osseointegration.


Clin Oral Implants Res


Ikawa T,Akizuki T,Shujaa Addin A,Fukuba S,Stavropoulos A,Izumi Y




Has Abstract


2019-10-01 00:00:00












  • Blood responses to titanium surface with TiO2 nano-mesh structure.

    abstract:OBJECTIVES:The goal of this study was to enhance the blood responses to titanium (Ti) surfaces used for dental implant application through the formation of a TiO2 nano-mesh surface layer produced by a fast electrochemical anodization treatment. MATERIAL AND METHODS:Electrochemical anodization treatments with different...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Huang HH,Chen JY,Lin MC,Wang YT,Lee TL,Chen LK

    更新日期:2012-03-01 00:00:00

  • Soft tissue around three different implant types after 1.5 years of functional loading without oral hygiene: a preliminary study in baboons.

    abstract::The purpose of this study was to determine the peri-implant soft tissue dimension (PSD) and peri-implant bone level (BL) of dental implants with different designs and surface modifications after functional loading without oral hygiene. Three types of dental implants were placed in the posterior jaws of adult baboons, ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Watzak G,Zechner W,Tangl S,Vasak C,Donath K,Watzek G

    更新日期:2006-04-01 00:00:00

  • Bacterial leakage along the implant-abutment interface: culture and DNA Checkerboard hybridization analyses.

    abstract:OBJECTIVE:Bacterial species have been found harboring the internal surface of dental implants as consequence of their failed connections. The aim of the present study was to compare the detection frequency of bacterial leakage from human saliva through the implant-abutment interface, under non-loading conditions, using...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: do Nascimento C,Miani PK,Pedrazzi V,Muller K,de Albuquerque RF Jr

    更新日期:2012-10-01 00:00:00

  • On the relationship between gingival biotypes and gingival thickness in young Caucasians.

    abstract:OBJECTIVES:To evaluate a possible relationship between gingival biotypes and gingival thickness, papilla height and gingival width. MATERIAL AND METHODS:Thirty-six adult subjects were stratified by their gingival biotype (GB), as defined by transparency of a periodontal probe through the buccal gingival margin, into "...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Fischer KR,Richter T,Kebschull M,Petersen N,Fickl S

    更新日期:2015-08-01 00:00:00

  • Adapted preparation technique for screw-type implants: explorative in vitro pilot study in a porcine bone model.

    abstract:OBJECTIVE:The aim of this study was to quantify the effect of adapted preparation on the insertion torque of self-tapping implants in cancellous bone. In adapted preparation, bone condensation - and thus, insertion torque - is controlled by changing the diameter of the drilling. MATERIAL AND METHODS:After preparation ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Beer A,Gahleitner A,Holm A,Birkfellner W,Homolka P

    更新日期:2007-02-01 00:00:00

  • Temperature and time variations during osteotomies performed with different piezosurgical devices: an in vitro study.

    abstract:AIM:The aim of this experimental in vitro study was to evaluate the effects of the piezoelectric device in temperature and time variations in standardized osteotomies performed with similar tip inserts in bovine bone blocks. METHODS:Two different piezosurgical devices were used the OE-F15(®) (Osada Inc., Los Angeles, ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Delgado-Ruiz RA,Sacks D,Palermo A,Calvo-Guirado JL,Perez-Albacete C,Romanos GE

    更新日期:2016-09-01 00:00:00

  • Morbidity of harvesting of chin grafts: a prospective study.

    abstract::In a prospective study, 20 patients who underwent harvesting of chin grafts as outpatients, were followed up for 12 months (3 further patients with incomplete follow-up data were excluded from the study). Preoperatively and 7 days, 1, 3, 6 and 12 months postoperatively, follow-up data were assessed. Evaluation of the ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Nkenke E,Schultze-Mosgau S,Radespiel-Tröger M,Kloss F,Neukam FW

    更新日期:2001-10-01 00:00:00

  • Immediate functional loading of TiOblast dental implants in full-arch edentulous maxillae: a 3-year prospective study.

    abstract:INTRODUCTION:Immediate functional loading of dental implants for full-arch restoration is a patient-friendly approach, shown to be feasible with a good long-term prognosis in a completely edentulous mandible. For the complete restoration of the maxilla, acceptable long-term clinical follow-up is lacking or based on cas...

    journal_title:Clinical oral implants research

    pub_type: 临床试验,杂志文章


    authors: Collaert B,De Bruyn H

    更新日期:2008-12-01 00:00:00

  • Bone-conditioned medium modulates the osteoconductive properties of collagen membranes in a rat calvaria defect model.

    abstract:OBJECTIVES:Collagen membranes are not limited to be occlusive barriers as they actively support bone regeneration. However, the impact of bone-derived growth factors on their osteoconductive competence has not been examined. METHODS:Twenty adult Sprague Dawley rats were included in the study. Calvaria defects with a d...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Kuchler U,Rybaczek T,Dobask T,Heimel P,Tangl S,Klehm J,Menzel M,Gruber R

    更新日期:2018-04-01 00:00:00

  • Early-stage osseointegration capability of a submicrofeatured titanium surface created by microroughening and anodic oxidation.

    abstract:OBJECTIVE:The role of nanoscale/submicron morphological features in the process of osseointegration is largely unknown. This study reports the creation of a unique submicrofeatured titanium surface by a combination of anodic oxidation and sandblasting and determines how the addition of this submicrofeature to a microro...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Yamada M,Ueno T,Minamikawa H,Ikeda T,Nakagawa K,Ogawa T

    更新日期:2013-09-01 00:00:00

  • The effect of zirconia and titanium implant abutments on light reflection of the supporting soft tissues.

    abstract:OBJECTIVES:To determine the difference in light reflection of oral mucosa covering titanium (Ti) or zirconia (ZrO(2)) abutments as it relates to the thickness of the covering mucosa. MATERIAL AND METHODS:Fifteen anterior implants (Astra Osseo speed(®)) in 11 patients were fitted with a Ti or a ZrO(2) abutment (cross-o...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: van Brakel R,Noordmans HJ,Frenken J,de Roode R,de Wit GC,Cune MS

    更新日期:2011-10-01 00:00:00

  • The influence of a biomaterial on the closure of a marginal hard tissue defect adjacent to implants. An experimental study in the dog.

    abstract:OBJECTIVES:The present experiment was performed to determine the influence of Bio-Oss on hard tissue formation at sites that, following implant installation, presented a 1-1.25 mm wide marginal defect. MATERIAL AND METHODS:Four Labrador dogs were used. The premolars and first molars on both sides of the mandible were ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Botticelli D,Berglundh T,Lindhe J

    更新日期:2004-06-01 00:00:00

  • Bone density in human dentate and edentulous mandibles using computed tomography.

    abstract::Mandibular bone density, vertebral density and resorption of the edentulous ridge were correlated in a group of 17 partially edentulous subjects. Bone density was quantified by Quantitative Computerized Tomography; resorption was evaluated on panoramic radiographs. Mean bone density in dentate areas was significantly ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Bassi F,Procchio M,Fava C,Schierano G,Preti G

    更新日期:1999-10-01 00:00:00

  • Resilient liner vs. clip attachment effect on peri-implant tissues of bar-implant-retained mandibular overdenture: a 1-year clinical and radiographical study.

    abstract:PURPOSE:The aim of this study was to compare between the effects of resilient liner and clip attachments of bar-implant-retained mandibular overdenture on peri-implant tissues. MATERIALS AND METHODS:In a randomized-controlled clinical trial, 30 edentulous male patients (mean age 62.5 years) were equally assigned to tw...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章,随机对照试验


    authors: Elsyad MA,Shoukouki AH

    更新日期:2010-05-01 00:00:00

  • Immunohistochemical, tomographic and histological study on onlay iliac grafts remodeling.

    abstract::The information concerning the molecular events taking place in onlay bone grafts are still incipient. The objective of the present study is to correlate the effects of perforation of resident bone bed on (1) the timing of onlay autogenous graft revascularization; (2) the maintenance of volume/density of the graft (as...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Faria PE,Okamoto R,Bonilha-Neto RM,Xavier SP,Santos AC,Salata LA

    更新日期:2008-04-01 00:00:00

  • The treatment of sinusitis following maxillary sinus grafting with the association of functional endoscopic sinus surgery (FESS) and an intra-oral approach.

    abstract:AIM OF THE STUDY:To present the results of a prospective study on the management of infectious complications following maxillary sinus floor elevation procedures with a combined endoscopic (FESS) and intra-oral approach. MATERIALS AND METHODS:From 2005 to 2009, twenty consecutive patients were diagnosed for sinusal ch...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章,多中心研究


    authors: Chiapasco M,Felisati G,Zaniboni M,Pipolo C,Borloni R,Lozza P

    更新日期:2013-06-01 00:00:00

  • Two-year clinical outcomes following non-surgical mechanical therapy of peri-implantitis with adjunctive diode laser application.

    abstract:BACKGROUND:Non-surgical mechanical therapy of peri-implantitis (PI) with/without adjunctive measures yields limited clinical improvements. AIM:To evaluate the clinical outcomes following non-surgical mechanical therapy of PI with adjunctive application of a diode laser after an observation period ≥2 years. MATERIAL A...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Mettraux GR,Sculean A,Bürgin WB,Salvi GE

    更新日期:2016-07-01 00:00:00

  • The effect of systemic antibiotics on clinical and patient-reported outcome measures of oral implant therapy with simultaneous guided bone regeneration.

    abstract:OBJECTIVES:The aim of the present superiority study was to determine the effect of systemic antibiotics primarily on patient-reported outcome measures (PROMs) and post-surgical complications in patients undergoing oral implant therapy with simultaneous guided bone regeneration (GBR). MATERIALS AND METHODS:A total of 2...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章,随机对照试验


    authors: Payer M,Tan WC,Han J,Ivanovski S,Mattheos N,Pjetursson BE,Zhuang L,Fokas G,Wong MCM,Acham S,Lang NP,International Team for Implantology (ITI) Antibiotic Study Group.

    更新日期:2020-05-01 00:00:00

  • The current use of patient-centered/reported outcomes in implant dentistry: a systematic review.

    abstract:AIM:To provide an update on the use of Patient-Reported Outcome Measures (PROMs) in the field of implant dentistry (1); to compare PROMs for prostheses supported by one or more implants to alternative treatment options or a healthy dentition (2). MATERIALS AND METHODS:The dental literature was searched on PubMed until...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章,评审


    authors: De Bruyn H,Raes S,Matthys C,Cosyn J

    更新日期:2015-09-01 00:00:00

  • X-ray microanalytical and morphological observations of the interface region between ceramic implant and bone.

    abstract::In 8 monkeys both the maxillary lateral incisors were extracted. In the 16 extraction sites an Al2O3-ceramic dental implant (Frialit) was immediately inserted. Eight implants were submerged under the oral mucosa and the other 8 were allowed to penetrate through the mucosa during the observation period. None of the imp...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Zetterqvist L,Anneroth G,Nordenram A,Wroblewski R

    更新日期:1995-06-01 00:00:00

  • Area moments of inertia as a measure of the mandible stiffness of the implant patient.

    abstract::It was hypothesized that the bending stiffness of the mandible is an important biomechanical parameter in implant dentistry. It was shown how this bending stiffness can be estimated by means of the principal area moments of inertia of the cortical and cancellous cross-sections as obtained by computed tomography, some ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Hansson S,Ekestubbe A

    更新日期:2004-08-01 00:00:00

  • A new index for rating aesthetics of implant-supported single crowns and adjacent soft tissues--the Implant Crown Aesthetic Index.

    abstract:OBJECTIVES:The important item of aesthetics is rarely included in evaluation studies. The aim of this study was to develop and validate an index for rating aesthetics of implant-supported single crowns and adjacent soft tissues. MATERIAL AND METHODS:Nine items were selected, which have an influence on the aesthetic re...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Meijer HJ,Stellingsma K,Meijndert L,Raghoebar GM

    更新日期:2005-12-01 00:00:00

  • Is the use of digital technologies for the fabrication of implant-supported reconstructions more efficient and/or more effective than conventional techniques: A systematic review.

    abstract:OBJECTIVE:To identify clinical studies evaluating efficiency and/or effectiveness of digital technologies as compared to conventional manufacturing procedures for the fabrication of implant-supported reconstructions. MATERIALS AND METHODS:A systematic search from 1990 through July 2017 was performed using the online d...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Mühlemann S,Kraus RD,Hämmerle CHF,Thoma DS

    更新日期:2018-10-01 00:00:00

  • Effects of Simvastatin on bone healing around titanium implants in osteoporotic rats.

    abstract:OBJECTIVES:Osteoporosis is known to impair the process of implant osseointegration. The recent discovery that statins (HMG-CoA reductase inhibitors) act as bone anabolic agents suggests that statins can be used as potential agents in the treatment of osteoporosis. Therefore, we hypothesized that statins will promote os...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Du Z,Chen J,Yan F,Xiao Y

    更新日期:2009-02-01 00:00:00

  • Influence of presence or absence of teeth adjacent to implants installed immediately into extraction sockets on peri-implant hard tissue levels: an experimental study in the dog.

    abstract:AIM:To evaluate the influence of the presence or absence of adjacent teeth on the level of the mesial and distal alveolar bony crest following healing at sites where implants were installed immediately into extraction sockets. MATERIAL AND METHODS:Six Labrador dogs were used. In the right side of the mandible, full-th...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Favero G,Botticelli D,Rea M,Pantani F,León IG,Lang NP

    更新日期:2013-03-01 00:00:00

  • The comparative evaluation of transcrestal and lateral sinus floor elevation in sites with residual bone height ≤6 mm: A two-year prospective randomized study.

    abstract:OBJECTIVES:To compare clinical and radiographic outcomes between transcrestal sinus floor elevation (TSFE) and lateral sinus floor elevation (LSFE) approaches of simultaneous implant placement in atrophic maxilla. MATERIALS AND METHODS:Patients with a residual bone height (RBH) ≤6 mm were enrolled and randomly assigne...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Zhou Y,Shi Y,Si M,Wu M,Xie Z

    更新日期:2020-11-21 00:00:00

  • The effect of periodontal parameters on the subgingival microbiota around implants.

    abstract::The study aimed to examine the relationship between the subgingival flora around implants and their periodontal parameters. Plaque samples from 561 implants (279 patients) were analyzed by means of differential phase contrast microscopy and compared with the sample site's probing depth, bleeding tendency on probing, a...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Papaioannou W,Quirynen M,Nys M,van Steenberghe D

    更新日期:1995-12-01 00:00:00

  • Levels of glycosaminoglycans in peri-implant sulcus fluid as a means of monitoring bone response to endosseous dental implants.

    abstract::The presence of certain glycosaminoglycans in peri-implant sulcus fluid may be an effective means of monitoring changes in bone metabolic activity following initial loading of implant abutments. This study has investigated levels of chondroitin 4 sulphate and hyaluronan in peri-implant sulcus fluid from titanium osseo...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Beck CB,Embery G,Langley MS,Waddington RJ

    更新日期:1991-10-01 00:00:00

  • Implant-tissue interfaces following treatment of peri-implantitis using guided tissue regeneration: a light and electron microscopic study.

    abstract::This study details the structural and ultrastructural features of the interfaces between titanium implants and their surrounding tissues. The material stemmed from an experiment in dogs in which guided tissue regeneration with Gore-Tex membranes was used to treat peri-implant, ligature-induced tissue breakdown around ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Schüpbach P,Hürzeler M,Grunder U

    更新日期:1994-06-01 00:00:00

  • Oblique lateral cephalometric radiographs of the mandible in implantology: usefulness and reproducibility of the technique in quantitative densitometric measurements of the mandible in vivo.

    abstract::In the literature intraoral periapical radiographs are commonly used for densitometric measurements of the mandible with implants. These films give detailed information of the implant and the surrounding bone. However, in extreme mandibular atrophy it can be difficult to obtain intraoral radiographs of adequate diagno...

    journal_title:Clinical oral implants research

    pub_type: 临床试验,杂志文章


    authors: Verhoeven JW,Ruijter J,Cune MS,Terlou M

    更新日期:2000-10-01 00:00:00