Abstract:
OBJECTIVES:The aim of the present study was to assess the influence of either recombinant human growth and differentiation factor 5 (rhGDF-5)- or recombinant human bone morphogenetic protein 2 (rhBMP-2)-coated natural bone mineral (NBM) on guided bone regeneration in a rat calvarial defect model. MATERIAL AND METHODS:Two monocortical critical-size calvarial defects (diameter 6 mm, depth 1.5 mm) were prepared in a total of 90 rats each (n=180 defects) and randomly allocated to the following groups: (1) NBM+collagen membrane (BG), (2) rhBMP-2+NBM+BG, (3) rhGDF-5+NBM+BG, (4) autogenous bone (AB)+BG, or (5) untreated control (C). At 1, 2, 4, 8, 16, and 24 weeks, dissected blocks were processed for histological [e.g. area (mm(2)) of mineralized tissue (MT)] and immunohistochemical (osteocalcin - OC, angiogenesis - TG) analysis. RESULTS:At 2 weeks, both coated NBM groups exhibited the formation of a thin hard tissue bridge underneath the BG. All test groups revealed significantly higher mean MT values than the C group at 24 weeks. rhBMP-2+NBM+BG-treated defects revealed significantly higher mean MT values in comparison with the AB+BG (8 and 24 weeks), NBM+BG (2 and 4 weeks), and rhGDF-5+NBM+BG (2, 16, and 24 weeks) groups, respectively. Immunoreactions to either OC or TG were comparable in all test groups. CONCLUSION:It was concluded that (i) all treatment procedures investigated supported bone regeneration at 24 weeks and (ii) rhBMP-2 might have the potential to improve the outcome of healing, particularly during the early stages of healing.
journal_name
Clin Oral Implants Resjournal_title
Clinical oral implants researchauthors
Schwarz F,Ferrari D,Sager M,Herten M,Hartig B,Becker Jdoi
10.1111/j.1600-0501.2009.01796.xsubject
Has Abstractpub_date
2009-11-01 00:00:00pages
1219-30issue
11eissn
0905-7161issn
1600-0501pii
CLR1796journal_volume
20pub_type
杂志文章abstract:OBJECTIVES:This in vitro study describes and characterizes a developed novel method to produce coatings on Ti. Hydrophobic coatings on substrates are needed in prosthetic dentistry to promote durable adhesion between luting resin cements and coated Ti surfaces. In implant dentistry the hydrophobic coatings on a Ti impl...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2012.02504.x
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:The aim of this prospective pilot study was to evaluate the prosthodontic maintenance as well as the implant outcome of single implant-retained mandibular overdentures over an observation period of 6 years. METHODS:Eleven edentulous patients received one single implant in the midline of the mandible. Dentur...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12427
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:The purpose of this prospective study on humans were to evaluate (a) the clinical outcome of alveolar distraction osteogenesis for the correction of vertically deficient edentulous mandibular ridges, (b) the clinical outcome of dental implants placed in the distracted areas, and (c) the quality and quantity of ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2005.01247.x
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVES:Alumina toughening enhances the mechanical properties of zirconia ceramics but the biocompatibility of this material has rarely been addressed. In this study, we examined the osteoblast response to alumina-toughened zirconia (ATZ) with different surface topographies. MATERIAL AND METHODS:Human osteoblasts i...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01735.x
更新日期:2009-11-01 00:00:00
abstract::Sinus augmentation has been advocated to be a surgical technique with predictable results in peri-implant surgery. Endoscopic surgery of the maxillary sinus so far has been used as diagnostic procedure. In this paper, the use of endoscopy is described as a low invasive adjunctive technique in sinus floor augmentation....
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1997.080612.x
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVES:To determine the difference in light reflection of oral mucosa covering titanium (Ti) or zirconia (ZrO(2)) abutments as it relates to the thickness of the covering mucosa. MATERIAL AND METHODS:Fifteen anterior implants (Astra Osseo speed(®)) in 11 patients were fitted with a Ti or a ZrO(2) abutment (cross-o...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.02082.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:To evaluate a possible relationship between gingival biotypes and gingival thickness, papilla height and gingival width. MATERIAL AND METHODS:Thirty-six adult subjects were stratified by their gingival biotype (GB), as defined by transparency of a periodontal probe through the buccal gingival margin, into "...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12356
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Connecting teeth and osseointegrated implants in fixed reconstructions is not generally recommended because of differences in their response to loading. AIM:The aim of the present study was to assess the clinical and radiographic performance of the teeth and implants used to support three unit fixed bridges...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2005.01110.x
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:Crestal bone loss around dental implants is a criterion for success as this could prevent loss of implant and superstructure. The macrogeometry of the implant could influence bone remodelling when the implant-abutment connection is placed at crestal bone level or above. The aim of this study was to evaluate c...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12581
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVES:The aims of this study were (i) to evaluate the efficacy of ridge preservation and repair procedures involving the application of SocketKAP(™) and SocketKAGE(™) devices following tooth removal and (ii) to evaluate alveolar bone volumetric changes at 6 months post-extraction in intact sockets or those with fa...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12687
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:A prospective double-blind randomised controlled trial was conducted to test the effect of prophylactic antibiotics on post-operative morbidity and osseointegration of dental implants. MATERIALS AND METHODS:Fifty-five subjects scheduled for implant surgery were enrolled. The patients were randomly assigned ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12124
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:Interforaminal implant surgery requires anatomical knowledge of the area and adequate information on the location of the various landmarks of significance such as the mental foramen, the anterior loop of the inferior alveolar nerve and the mandibular incisive canal. Cone beam computed tomography (CBCT) is a ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02261.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this prospective study was to evaluate one-stage dental implants clinically and radiographically after 10 years in function. MATERIAL AND METHODS:Twenty-five patients with a total of 68 implants [46 hollow screws (HS) and 22 hollow cylinders (HC)] who previously participated in 5-year prospect...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2007.01479.x
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVES:Although implants with a roughened surface are widely used today, little is known about the long-term effect of a roughened surface compared with the conventional machined surface on clinical and radiographic parameters. The purpose of this study is to investigate the long-term differences between moderately...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2009.01768.x
更新日期:2009-11-01 00:00:00
abstract::The aim of this study was to investigate whether a new connective tissue attachment can occur on a surface of hydroxyapatite (HA) when periodontal ligament (PDL)-derived cells with the ability to form new connective tissue attachment are allowed to populate the surface of HA. Six maxillary canines from 3 cats were use...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1993.040303.x
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVES:The aim of this prospective study was to determine how the crown-implant ratio (C/I ratio) influences crestal bone loss and implant success rates after a 3-year follow-up, using implants with a sintered porous surface (SPS). MATERIALS AND METHODS:On the basis of preestablished inclusion and exclusion criter...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12105
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:To use cone beam computed tomography (CBCT) to assess the alterations of socket dimensions after a 6-month healing period following molar extraction. MATERIALS AND METHODS:Seventeen molars were extracted due to advanced periodontitis. CBCT scans were taken immediately after extraction and once more 6 months ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13418
更新日期:2019-04-01 00:00:00
abstract::The aim of this controlled, parallel design clinical study was to compare the effectiveness of an Er:YAG laser (ERL) to that of mechanical debridement using plastic curettes and antiseptic therapy for nonsurgical treatment of peri-implantitis. Twenty patients with moderate to advanced peri-implantitis lesions were ran...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2004.01051.x
更新日期:2005-02-01 00:00:00
abstract::The present study describes the use of unbiased stereological methods for the quantitative evaluation of the amount of regenerated bone. Using the principle of guided bone regeneration the amount of regenerated bone after placement of degradable or non-degradable membranes covering defects in rabbit calvaria was compa...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1998.090303.x
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVES:The present study aimed at evaluating the marginal bone resorption and the peri-implant tissue conditions around Narrow-Neck ITI implants in the implant-prosthetic treatment of the agenesis of maxillary lateral incisors. MATERIAL AND METHODS:Thirty patients affected by monolateral or bilateral agenesis of t...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0501.2005.01188.x
更新日期:2006-02-01 00:00:00
abstract::Microbiologic examinations of implants have shown that certain microorganisms described as periodontal pathogens may have an influence on the development and the progression of peri-implant disease. This experimental study aimed to examine the bactericidal effect of irradiation with a soft laser on bacteria associated...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1997.080401.x
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVE:Long-term success of dental implants depends on healthy peri-implant soft tissues and adequate bone levels. This prospective study aims to assess bone level changes around implants with internal conical connection and platform-switching abutments in the posterior mandible. MATERIAL AND METHODS:Adult patients...
journal_title:Clinical oral implants research
pub_type: 杂志文章,多中心研究
doi:10.1111/clr.12644
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:This study aimed to determine bone level changes after 5-6 years of follow-up for a large group of one-stage dental implants consecutively placed in private practice. Potential confounding factors influencing crestal bone loss (CBL) were also assessed. MATERIALS AND METHODS:A total of 378 transmucosal Strau...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12083
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:To compare the effectiveness of free-handed (FH), pilot-drill guided (PG) and fully guided (FG) implant surgery by means of the apical global deviation (AGD) in relation to the additional financial cost and time spent. MATERIALS AND METHODS:Thirty-three partially edentulous patients in need of ≥2 implants i...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.13399
更新日期:2019-02-01 00:00:00
abstract::Breakdown of bone around oral implants following occlusal overload or plaque accumulation was evaluated in monkeys. 5 screw-type implants of pure titanium (Astra Tech) were inserted in the mandible of 4 monkeys (Macaca Fascicularis). 6 months after insertion of the implants a fixed partial prosthesis was mounted on th...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.1997.tb00001.x
更新日期:1997-02-01 00:00:00
abstract::The effect of bioactive glass (BG) and calcium carbonate (CC) granules on bone formation around titanium and BG implants projecting into the medullary space of rabbit tibia was studied. The bone marrow tissue was removed and the medullary space was filled either with BG or CC (Biocoral) granules (phi 630-800 microns)....
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1997.080204.x
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:Recent studies have suggested that magnesium (Mg) ions exert a beneficial effect on implant osseointegration. This study assessed the osseointegration of nanoporous titanium (Ti) surface incorporating the Mg produced by hydrothermal treatment in rabbit cancellous bone to determine whether this surface would f...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.02144.x
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:In a prospective pilot study, short< or =10 mm ITI-SLA implants were placed in the resorbed posterior maxilla by means of an osteotome sinus floor elevation (OSFE) procedure without grafting material. This paper presents 3-year data assessing bone-level changes around implants. MATERIAL AND METHODS:Twenty-fi...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01696.x
更新日期:2009-07-01 00:00:00
abstract::The aim of the present study was (i) to investigate the relation between specific interleukin-1 (IL-1) gene polymorphisms and peri-implant bone loss at osseointegrated ITI(R) dental implants and (ii) to explore the association between these allelic variants of the IL-1 gene complex and peri-implant mucosal inflammatio...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2003.140102.x
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVES:To evaluate the effect of vertical and periosteal-releasing incisions (PRI) on the extension of the buccal flap in a trapezoidal flap design. MATERIAL AND METHODS:Thirty patients scheduled for implant surgery accompanied by bone augmentation were recruited. The amount of flap extension pulled with a minimal...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02244.x
更新日期:2012-08-01 00:00:00