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Sinus augmentation analysis revised: the gradient of graft consolidation.

Abstract：

OBJECTIVE:Graft consolidation follows a gradient that reflects the properties of bone substitutes at sites of sinus augmentation. Here we present an analytical method to investigate the process of graft consolidation taking the distance from the maxillary host bone into account. MATERIAL AND METHODS:We therefore evaluated histological specimens, 6 and 12 weeks after the sinus of minipigs was augmented with Bio-Oss((R)), a deproteinized bovine bone mineral, and Ostim((R)), an aqueous paste of synthetic nanoparticular hydroxyapatite. A curve was drawn that represents the changes in histomorphometric parameters within a given distance from the maxillary host bone. RESULTS:Based on this curve, three regions of interest were defined: R1 (0-1 mm) the bridging distance where new bone is laid onto the host bone, R2 (2-3 mm) a region of osteoconduction where new bone exclusively grows on the biomaterial, R3 (4-5 mm) and a region of osteoconduction where bone formation has reached its maximal extension. Qualitative and quantitative analysis of the three regions can reveal differences in graft consolidation, depending on the bone substitutes and the observation period [Bone volume (BV) per tissue volume after 6 weeks: R1: 19+/-8.4% for Bio-Oss((R)) and 42.9+/-13.2% for Ostim((R)) (P=0.03), R2: 3+/-2.4% for Bio-Oss((R)) and 14.7+/-9.5% for Ostim((R)) (P=0.03), R3: 5+/-4.1% for Bio-Oss((R)) and 5.3+/-5.3% for Ostim((R)) (P=0.86). BV per tissue volume after 12 weeks: R1: 38.0+/-13.3% for Bio-Oss((R)) and 53.3+/-6.6 for Ostim((R)) (P=0.04), R2: 14+/-12.2 for Bio-Oss((R)) and 26.4+/-11 for Ostim((R)) (P=0.18), R3: 6.6+/-7 for Bio-Oss((R)) and 10.7+/-5.8 for Ostim((R)) (P=0.32) after 12 weeks]. CONCLUSION:Based on the graft consolidation gradient, the impact of bone substitutes to modulate the process of bone formation and the kinetic of degradation within a distinct region of the augmented sinus can be investigated.

journal_name

Clin Oral Implants Res

journal_title

Clinical oral implants research

authors

Busenlechner D,Huber CD,Vasak C,Dobsak A,Gruber R,Watzek G

doi

10.1111/j.1600-0501.2009.01733.x

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

1078-83

issue

eissn

0905-7161

issn

1600-0501

pii

CLR1733

journal_volume

pub_type

杂志文章

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Sinus augmentation analysis revised: the gradient of graft consolidation.