Abstract:
OBJECTIVES:Studies showing that osteoblasts exhibit a more differentiated phenotype on rough titanium (Ti) surfaces and osteoclast-resorbed bone surfaces used materials characterized by average peak to valley distance (Ra). Other surface features impacting the cells include distance between peaks, curvature of the valleys, and relative distribution of flat and smooth regions. We used novel Ti surfaces prepared by electrochemical micromachining as models to examine specific contributions of individual design features to osteoblast response. Results show that micron-scale topography modulates cell number, cell morphology and prostaglandin E2 (PGE2). In the presence of the appropriate microtopography, submicron-scale rugosity modulates differentiation and transforming growth factor-beta1 (TGF-beta1) levels. In this study, we examined the role of different types of submicron-scale structures. MATERIAL AND METHODS:Thirty micrometer diameter craters on Ti disks were produced by photolithography resulting in an electropolished smooth surface, and arranged so that inside crater area vs. outside flat area was 6 (30/6). Submicron-scale structures were superposed by acid etching and porous anodization. Ra's were 700, 400, 60 nm on acid-etched, porous anodized and smooth 30/6 surfaces, respectively. RESULTS:MG63 osteoblast-like cells were sensitive to submicron-scale architecture. Cell morphology on anodized surfaces was similar to morphology on smooth surfaces, whereas on etched surfaces, cells had a more elongated differentiated shape. Cell number was greatest on smooth surfaces > anodized > etched. Osteocalcin and PGE2 were affected in a reverse manner. Active TGF-beta1 was greatest on etched 30/6 surfaces > anodized > smooth; latent TGF-beta1 was elevated on all rough surfaces. CONCLUSIONS:These results support our previous observations that submicron-scale structures modulate osteoblastic phenotype and show that the physical properties of the submicron-scale structures are important variables in determining osteoblast response to substrate topography.
journal_name
Clin Oral Implants Resjournal_title
Clinical oral implants researchauthors
Zhao G,Zinger O,Schwartz Z,Wieland M,Landolt D,Boyan BDdoi
10.1111/j.1600-0501.2005.01195.xsubject
Has Abstractpub_date
2006-06-01 00:00:00pages
258-64issue
3eissn
0905-7161issn
1600-0501pii
CLR1195journal_volume
17pub_type
杂志文章abstract:OBJECTIVES:To assess retrospectively the cumulative costs for the long-term oral rehabilitation of patients with birth defects affecting the development of teeth. METHODS:Patients with birth defects who had received fixed reconstructions on teeth and/or implants > or =5 years ago were asked to participate in a compreh...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01711.x
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVES:The aim of this study is twofold: to assess the esthetic outcome of single dental implant restorations in the anterior maxillary area after up to 3 years of function, and to evaluate the relationship between the esthetic outcome and oral health-related quality of life. MATERIALS AND METHODS:Twenty patients ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12922
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the effects of a nanostructured calcium coating on the surfaces of blasted Ti implants on peri-implant bone formation in the rabbit tibiae. MATERIAL AND METHODS:Threaded implants (3.75 mm in diameter, 6 mm in length) were roughened by hydroxyapatite (HA) blasting ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2006.01323.x
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Low-temperature synthesized calcium phosphates are produced by mixing calcium phosphate powders in an aqueous solution resulting in a precipitated phase. These compounds can be formulated in several forms (e.g. injectable cements and implantable blocks), and are commonly used as bone substitutes and drug del...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01864.x
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:The aim of this prospective study was to evaluate the 5-year performance and success rate of titanium screw-type implants with the titanium plasma spray (TPS) or the sand-blasted, large grit, acid-etched (SLA) surface inserted in a two-stage sinus floor elevation (SFE) procedure in the posterior maxilla. MA...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01573.x
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:There is limited knowledge regarding the strength of zirconia abutments with internal and external implant abutment connections and zirconia abutments supported by a titanium resin base (Variobase, Straumann) for narrow diameter implants. OBJECTIVES:To compare the fracture strength of narrow diameter abutme...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13139
更新日期:2018-04-01 00:00:00
abstract:AIM:The objective of the study was to compare (i) esthetic, (ii) clinical and (iii) patient-centered outcomes following immediate (Type 1) and early implant placement (Type 2). MATERIAL AND METHODS:Thirty-eight subjects needing a single extraction (premolar to premolar) were randomly allocated to Type 1 or Type 2 impl...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12577
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Alumina-toughened zirconia (ATZ) is a possible alternative material to titanium for oral implants. No data are available on the fracture strength of ATZ oral implants. PURPOSE:The purpose of this study was to examine one-piece implants made of ATZ ceramic under artificial loading conditions and to compare t...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.01954.x
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVES:To evaluate a possible relationship between gingival biotypes and gingival thickness, papilla height and gingival width. MATERIAL AND METHODS:Thirty-six adult subjects were stratified by their gingival biotype (GB), as defined by transparency of a periodontal probe through the buccal gingival margin, into "...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12356
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVES:The aim of the present study was to evaluate and compare naturally occuring and ligature-induced peri-implantitis bone defects in humans and dogs. MATERIAL AND METHODS:Twenty-four partially and fully edentulous patients undergoing peri-implant bone augmentation procedures due to advanced peri-implant infect...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2006.01320.x
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:There are various alternatives for the management of oral conditions that may lead to or already have lead to partial or full edentulism. Economic evaluations measure the efficiency of alternative healthcare interventions and provide useful information for decision-making and the allocation of scarce resource...
journal_title:Clinical oral implants research
pub_type: 共识发展会议,杂志文章,评审
doi:10.1111/clr.12630
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVES:The aim of this prospective study was to determine how the crown-implant ratio (C/I ratio) influences crestal bone loss and implant success rates after a 3-year follow-up, using implants with a sintered porous surface (SPS). MATERIALS AND METHODS:On the basis of preestablished inclusion and exclusion criter...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12105
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:The aim of this investigation was to evaluate the potential effects of the systemically delivered combination of calcium supplementation and cholecalciferol and of the locally applied biphasic calcium alloplast on the surgically produced alveolar sockets at the early healing stage in a dog model. MATERIALS ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02284.x
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to test the retention of metal copings fabricated to fit on the one-groove, one flat-sided solid titanium abutment using six different cements. MATERIALS AND METHODS:Ten hollow screw 3.8 mm ITI implants were mounted in acrylic resin blocks. A solid titanium abutment was placed o...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2002.130401.x
更新日期:2002-08-01 00:00:00
abstract::In the present multi-center study, non-submerged ITI implants were prospectively followed to evaluate their long-term prognosis in fully and partially edentulous patients. In a total of 1003 patients, 2359 implants were consecutively inserted. Following a healing period of 3-6 months, the successfully integrated impla...
journal_title:Clinical oral implants research
pub_type: 杂志文章,多中心研究
doi:10.1034/j.1600-0501.1997.080302.x
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVES:To evaluate the effect of enamel matrix derivative in liquid form (EMD-liquid) as adjunct to grafting with natural bovine bone (NBB), on new bone formation and osseointegration in buccal dehiscence defects at dental implants. MATERIAL AND METHODS:In six beagles, 3 months after extraction of the mandibular p...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13512
更新日期:2019-10-01 00:00:00
abstract::This paper describes a surgical technique that permits the achievement of bilateral simultaneous augmentation of the maxillary sinus floor with the use of autologous bone harvested from the mandibular symphysis alone. Out of a group of 26 partially edentulous patients consecutively treated for sinus augmentation in an...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2003.140210.x
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVES:The goal of this study was to enhance the blood responses to titanium (Ti) surfaces used for dental implant application through the formation of a TiO2 nano-mesh surface layer produced by a fast electrochemical anodization treatment. MATERIAL AND METHODS:Electrochemical anodization treatments with different...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.02152.x
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:To analyze the outcomes of static computer-aided implant placement (sCAIP) compared to partially guided (PGIP) and free-handed (FHIP) implant placement. MATERIAL AND METHODS:This study was registered in PROSPERO (CRD42019131397). A comprehensive literature search was performed by two independent examiners. O...
journal_title:Clinical oral implants research
pub_type: 杂志文章,meta分析
doi:10.1111/clr.13635
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:To investigate: (1) the effect of the lateral window technique for maxillary sinus augmentation on sinus membrane thickness, and (2) to identify factors associated with the mean postoperative surgical space. MATERIAL AND METHODS:This retrospective cohort study included 37 sinuses corresponding to 37 consecu...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2012.02520.x
更新日期:2013-10-01 00:00:00
abstract:AIM:The aim of this experimental in vitro study was to evaluate the effects of the piezoelectric device in temperature and time variations in standardized osteotomies performed with similar tip inserts in bovine bone blocks. METHODS:Two different piezosurgical devices were used the OE-F15(®) (Osada Inc., Los Angeles, ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12709
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:One main problem occurring after bone grafting is resorption, leading to insufficient bone volume and quality, and may subsequently cause dental implant failure. Comparison of graft volume and bone density of iliac crest and calvarial transplants determined by animal studies demonstrates significantly lower ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2005.01182.x
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:Because pixel or voxel values obtained from cone-beam computed tomography (CBCT) images are not absolute values, the bone density cannot be evaluated. Hence, the regression line between voxel values of CBCT and the bone mineral density (BMDs) of multislice CT (MSCT) was prospectively evaluated to investigate ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.01950.x
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the long-term results of the surgical treatment of single peri-implantitis intrabony defects, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC). MATERIAL AND METHODS:The original population consisted of 26 patients with one crater-like defect, arou...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13028
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND/AIMS:Clinical probing of the soft tissues around oral implants has become a frequently used parameter for clinical monitoring. However, the healing of the disruption of the soft tissue seal as a result of probing has not yet been studied. The purpose of this study was to evaluate the healing events in the pe...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2002.130601.x
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:Interforaminal implant surgery requires anatomical knowledge of the area and adequate information on the location of the various landmarks of significance such as the mental foramen, the anterior loop of the inferior alveolar nerve and the mandibular incisive canal. Cone beam computed tomography (CBCT) is a ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02261.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:The aim of this controlled in vitro study was to identify and quantify up to 38 microbial species penetrating through the screw-retained implant prostheses with different sealing materials. MATERIAL AND METHODS:Sixty morse cone implants were restored with single-unit screw-retained prostheses. All the compo...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12790
更新日期:2017-02-01 00:00:00
abstract:AIMS:To determine whether endoscope-guided sinus elevation procedures can be consistently used to create sufficient bone support for stable implant placement and long-term implant success. MATERIAL AND METHODS:Sixty-two implants were surgically placed into 30 patients (14 men and 16 women) following internal sinus ele...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01561.x
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:The aim of the present publication was to report on the EAO Workshop group-4 discussions and consensus statements on the five reviews previously prepared. These reviews provided the scientific evidence on the effect of crown-to-implant ratio, on reconstructions with cantilevers in fully and partially edentul...
journal_title:Clinical oral implants research
pub_type: 共识发展会议,杂志文章
doi:10.1111/clr.13284
更新日期:2018-10-01 00:00:00
abstract::It has been documented that the long-term clinical outcome of the Brånemark system is very favourable. However, failures do occur before and after loading. This study examined the differences in marginal bone loss between standard and self-tapping fixtures and attempted to explain excessive marginal bone loss or loss ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1992.030302.x
更新日期:1992-09-01 00:00:00