Abstract:
OBJECTIVE:A systematic review and meta-analysis are carried out to assess the scientific evidence that bisphosphonate therapy can decrease the success rate of dental implants. MATERIAL AND METHODS:The PubMed (Medline) database was used to search for articles published up until February 22, 2014. The meta-analysis was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). The Newcastle-Ottawa scale (NOS) was used to assess study quality. RESULTS:The combinations of search terms resulted in a list of 256 titles. Fourteen finally met the inclusion criteria and were thus selected for inclusion in the systematic review. Eight studies (six retrospective and two prospective) were included in the meta-analysis, with a total of 1288 patients (386 cases and 902 controls) and 4562 dental implants (1090 dental implants in cases and 3472 in controls). The summary odds ratio (OR = 1.43, P = 0.156) indicates that there is not enough evidence that bisphosphonates have a negative impact upon implant survival. According to the number need to harm (NNH), over 500 dental implants are required in patients receiving bisphosphonate treatment to produce a single implant failure. CONCLUSION:Our results show that dental implant placement in patients receiving bisphosphonates does not reduce the dental implant success rate. On the other hand, such patients are not without complications, and risk evaluation therefore must be established on an individualized basis, as one of the most serious though infrequent complications of bisphosphonate therapy is bisphosphonate-related osteonecrosis of the jaws. Given the few studies included in our meta-analysis, further prospective studies involving larger sample sizes and longer durations of follow-up are required to confirm the results obtained.
journal_name
Clin Oral Implants Resjournal_title
Clinical oral implants researchauthors
Ata-Ali J,Ata-Ali F,Peñarrocha-Oltra D,Galindo-Moreno Pdoi
10.1111/clr.12526subject
Has Abstractpub_date
2016-02-01 00:00:00pages
e38-46issue
2eissn
0905-7161issn
1600-0501journal_volume
27pub_type
杂志文章,meta分析,评审abstract:AIM:The aim of this prospective study was to evaluate the outcome of computer-guided flapless placement and immediate loading of four conical screw-type implants in the interforaminal region. PATIENTS AND METHODS:From May to August 2003, 25 consecutive patients (m : f=16 : 9) with edentulous mandibles were included in...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2007.01370.x
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVES:To assess retrospectively, over at least 5 years, the incidences of technical and biological complications and failures in young adult patients with birth defects affecting the formation of teeth. MATERIAL AND METHODS:All insurance cases with a birth defect that had crowns and fixed dental prostheses (FDPs)...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01720.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:Minor sinus floor elevation is a method with relatively high predictability but is technically demanding. Improvement of the technique and increase in the predictability are desirable. MATERIAL AND METHODS:A clinical protocol for minor sinus floor elevation with SLA-ITI (large grit acid-etched implants with...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2005.01161.x
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:To review systematically whether supportive implant treatment during a follow-up of at least 10 years after functional loading is effective in prevention of biological complications and fixture loss. METHODS:A MEDLINE search was conducted for the period of 1965 to April 2006 of longitudinal clinical studies ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0501.2007.01447.x
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to build, around several types of input data, a decision analysis model for dental extraction strategy in periodontitis patients. MATERIALS AND METHODS:The decision analysis was based on the following scenario: a fictitious adult chronic periodontitis patient with no chief compl...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01850.x
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:To compare ear, nose, and throat (ENT) specialists and dentists assessing health or pathology of maxillary sinuses using cone beam computed tomography (CBCT). MATERIAL AND METHODS:Two ENT specialists and two oral surgeons assessed 100 CBCT datasets of healthy patients referred for dental implant placement i...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13582
更新日期:2020-05-01 00:00:00
abstract::Microbial plaque accumulation on titanium dental implant surfaces can result in an inflammatory condition of the surrounding tissues. Cleaning of such a contaminated surface, in vivo, by means of a solution of amino-alcohol, following surgical exposure, has been proposed. However, the tissue healing following treatmen...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1999.100303.x
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVES:The aim of the present multi-center study was to evaluate the treatment outcome of immediately restored one-piece single-tooth implants with a diameter of 3 mm after 1 year. MATERIAL AND METHODS:A total of 57 one-piece implants (NobelDirect 3.0) were inserted in 47 patients (26 females, 21 males) with a mea...
journal_title:Clinical oral implants research
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1600-0501.2011.02174.x
更新日期:2012-01-01 00:00:00
abstract::Bovine mineral spongiosa block (B-SB) was used as a bone substitute in sinus augmentation procedures in 10 consecutive patients. Implants were placed during the same session. The purpose of this study was to histopathologically examine the healing of the grafted site around the implants at 12 months. Radiographic foll...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2002.130411.x
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVES:The objectives of this systematic review were to assess the 5-year survival of resin-bonded bridges (RBBs) and to describe the incidence of technical and biological complications. METHODS:An electronic Medline search complemented by manual searching was conducted to identify prospective and retrospective co...
journal_title:Clinical oral implants research
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0501.2007.01527.x
更新日期:2008-02-01 00:00:00
abstract::The study aimed to examine the relationship between the subgingival flora around implants and their periodontal parameters. Plaque samples from 561 implants (279 patients) were analyzed by means of differential phase contrast microscopy and compared with the sample site's probing depth, bleeding tendency on probing, a...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1995.060401.x
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVE:To analyze the outcomes of static computer-aided implant placement (sCAIP) compared to partially guided (PGIP) and free-handed (FHIP) implant placement. MATERIAL AND METHODS:This study was registered in PROSPERO (CRD42019131397). A comprehensive literature search was performed by two independent examiners. O...
journal_title:Clinical oral implants research
pub_type: 杂志文章,meta分析
doi:10.1111/clr.13635
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:To determine the difference in light reflection of oral mucosa covering titanium (Ti) or zirconia (ZrO(2)) abutments as it relates to the thickness of the covering mucosa. MATERIAL AND METHODS:Fifteen anterior implants (Astra Osseo speed(®)) in 11 patients were fitted with a Ti or a ZrO(2) abutment (cross-o...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.02082.x
更新日期:2011-10-01 00:00:00
abstract:AIM:Titanium dental implants are an important treatment option in the replacement of missing teeth. Implant failures can, however, occur and may be promoted by the loss of tissue as a result of local bacterial infection (peri-implantitis). OBJECTIVES:Bacterial adherence to implant surfaces is believed to be influenced...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2006.01274.x
更新日期:2006-12-01 00:00:00
abstract::Treatment with denture for edentulous people is highly important for maintaining quality of life. However, its effect on the brain is unknown. In this experimental study, we hypothesized that dental prosthesis can recover not only the physical condition of mastication system but also the regional brain activity. We ev...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2005.01171.x
更新日期:2005-12-01 00:00:00
abstract::The purpose of this study was to evaluate retrospectively, after a period of 6-48 months follow-up of prosthetic loading, the survival rate of 103 zygomatic implants inserted in 55 totally edentulous severely resorbed upper jaws. Fifty-five consecutive patients, 41 females and 14 males, with severe maxillary bone reso...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1046/j.1600-0501.2003.00985.x
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to radiologically and histologically evaluate the graft healing and volumetric changes after lateral augmentation with two different compositions of deproteinized bovine bone (DPBB) and autogenous bone (AB). MATERIAL AND METHODS:Thirteen patients with a mean age of 59.6 ± 12.1 years ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12143
更新日期:2014-03-01 00:00:00
abstract::Four different surface modifications were designed. Forty screw-shaped implants were divided into 4 groups, 10 screws in each. Every screw was prepared with 2 different surface topographies. The surface topography was measured with a confocal laser scanning profilometer and the surface roughness was characterized usin...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1998.090102.x
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVES:The present experiment was performed to determine the influence of Bio-Oss on hard tissue formation at sites that, following implant installation, presented a 1-1.25 mm wide marginal defect. MATERIAL AND METHODS:Four Labrador dogs were used. The premolars and first molars on both sides of the mandible were ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1046/j.1600-0501.2003.01008.x
更新日期:2004-06-01 00:00:00
abstract:AIM:The objective of the study was to compare (i) esthetic, (ii) clinical and (iii) patient-centered outcomes following immediate (Type 1) and early implant placement (Type 2). MATERIAL AND METHODS:Thirty-eight subjects needing a single extraction (premolar to premolar) were randomly allocated to Type 1 or Type 2 impl...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12577
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine the long-term outcome of implant insertion in the augmented severely atrophied maxilla. STUDY DESIGN:Three hundred and twenty-four implants were inserted in 35 patients (eight males, 27 females, average age 57.6 years) in extremely atrophied maxillae after osteotomy and...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2004.01074.x
更新日期:2004-12-01 00:00:00
abstract::The purpose of this study was to clinically evaluate an absorbable collagen membrane (Bio-Gide) and a nonabsorbable polytetrafluoroethylene membrane (PTFE), associated or not with bone grafts, for the treatment of ligature-induced peri-implantitis defects in dogs. The bilateral mandibular premolars were removed from 5...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2001.012002115.x
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVES:To evaluate the effect of enamel matrix derivative in liquid form (EMD-liquid) as adjunct to grafting with natural bovine bone (NBB), on new bone formation and osseointegration in buccal dehiscence defects at dental implants. MATERIAL AND METHODS:In six beagles, 3 months after extraction of the mandibular p...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13512
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:Long-term success of dental implants depends on healthy peri-implant soft tissues and adequate bone levels. This prospective study aims to assess bone level changes around implants with internal conical connection and platform-switching abutments in the posterior mandible. MATERIAL AND METHODS:Adult patients...
journal_title:Clinical oral implants research
pub_type: 杂志文章,多中心研究
doi:10.1111/clr.12644
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:This study was conducted to evaluate the effect of barrier membranes on sandwich bone augmentation (SBA) for the treatment of implant dehiscence defects. MATERIAL AND METHODS:Twenty-six implant-associated buccal dehiscence defects in 22 patients were treated according to the SBA concept - mineralized human ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2007.01408.x
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:The purpose of the present study was to evaluate the survival rate of dental implants in previously failed implant sites. In addition, factors that might affect the outcome of these redo procedures were also explored. MATERIAL AND METHODS:Patients that had failed dental implants, which were replaced with th...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2007.01466.x
更新日期:2008-03-01 00:00:00
abstract:AIM:To evaluate the influence of the presence or absence of adjacent teeth on the level of the mesial and distal alveolar bony crest following healing at sites where implants were installed immediately into extraction sockets. MATERIAL AND METHODS:Six Labrador dogs were used. In the right side of the mandible, full-th...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12006
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:To evaluate implant survival rate, any complications, and changes in residual alveolar bone height (RABH) using saline or platelet-rich fibrin (PRF) filling after hydraulic transcrestal sinus lifting. METHODS:Dental implants were placed after hydraulic transcrestal sinus lifting and the filling of saline (2...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.13655
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the success rate of chemically modified and conventional sandblasted acid-etched surface (SLA) titanium implants in irradiated oral squamous cell carcinoma patients. MATERIAL AND METHODS:Twenty patients with a mean age of 61.1 years were treated with dental implants after ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2010.02050.x
更新日期:2011-05-01 00:00:00
abstract:AIM:The purpose of this in vitro study was to investigate the influence of degree of stiffness of implant-abutment connection of a Brånemark implant system on load- deflection ratios in three dimensions of the beam-end of a screw-retained stiff cantilever beam when subjected to vertically directed loads. MATERIAL AND ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2012.02563.x
更新日期:2013-11-01 00:00:00