Vaspin--a link of obesity and psoriasis?

abstract：:Recently, decreased interferon-gamma (IFN-gamma) and increased interleukin (IL)-4 production have been reported in measurements of the content of the cytokines in culture supernatants of peripheral blood mononuclear cells (PBMC) obtained from patients with atopic dermatitis (AD). These data suggest deviation of PBMC i...

journal_title：Experimental dermatology

authors： Nakagawa S,Aiba S,Tagami H

更新日期：1998-04-01 00:00:00

abstract：:The potentially severe side effects of systemic corticosteroids and immunosuppressants used in Pemphigus vulgaris (PV) call for novel therapeutic approaches. In this context, pharmacological inhibition of major pathogenic signalling effectors represents a promising alternative. However, we have also shown that overinh...

journal_title：Experimental dermatology

authors： Hariton WVJ,Galichet A,Vanden Berghe T,Overmiller AM,Mahoney MG,Declercq W,Müller EJ

更新日期：2017-12-01 00:00:00

abstract：:T cells play a major role in inflammatory skin disorders such as psoriasis vulgaris and atopic dermatitis. They are both active on the level of cell-to-cell interaction and by the secretion of pro-inflammatory mediators. CD26 is a lymphocyte membrane-associated dipeptidyl peptidase IV (DPP IV), which is able to inacti...

journal_title：Experimental dermatology

authors： Bock O,Kreiselmeyer I,Mrowietz U

更新日期：2001-12-01 00:00:00

abstract：:Hair follicles cyclically regenerate throughout adult mammalian life, owing to a resident population of epithelial hair follicle stem cells. Stem cell (SC) activity drives bouts of follicle growth, which are periodically interrupted by follicle regression and rest. These phases and the transitions between them are tig...

journal_title：Experimental dermatology

authors： Martino PA,Heitman N,Rendl M

更新日期：2020-10-02 00:00:00

abstract：:Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering skin disease and is characterized by the presence of autoantibodies directed against the hemidesmosomal proteins BP180 and BP230 that can be detected in the skin and serum of BP patients. Histologically, the dermal infiltration of eosinophil...

journal_title：Experimental dermatology

authors： Simon D,Borradori L,Simon HU

更新日期：2017-12-01 00:00:00

abstract：:The adoptive transfer of engineered T cells represents an important approach in immunotherapy of melanoma. However, relapse of the tumor can occur due to immune-escape mechanisms developed by the tumor cells, for example antigen loss, downregulation of the major histocompatibility complex presentation machinery and de...

journal_title：Experimental dermatology

authors： Uslu U,Schuler G,Dörrie J,Schaft N

更新日期：2016-11-01 00:00:00

abstract：:Macrophages play important roles in immunity and inflammation, and in allergic, granulomatous and neoplastic diseases. Here, we present the indepth results of an ongoing study of macrophage differentiation pathways in cutaneous macrophage disorders and in vitro. Up to now, a total of 40 cases of cutaneous macrophage d...

journal_title：Experimental dermatology

authors： Kodelja V,Goerdt S

更新日期：1994-12-01 00:00:00

abstract：:The transplantation of allogeneic cells such as pancreatic islet cells, bone marrow, and keratinocytes for skin replacement is in growing use clinically. Present techniques which are used to distinguish transplanted allogeneic cells from phenotypically identical host cells in chimeric tissue have serious limitations. ...

journal_title：Experimental dermatology

authors： Young DM,Summers WC,Cuono CB

更新日期：1993-02-01 00:00:00

abstract：:In the 1970s, studies of tissue architecture and cell proliferation were used to formulate a new model of epidermal homeostasis. This asserted that the tissue was maintained by long-lived, slow-cycling, self-renewing stem cells that generate a short-lived population of transit amplifying (TA) cells, which undergo term...

journal_title：Experimental dermatology

authors： Doupé DP,Jones PH

更新日期：2012-04-01 00:00:00

abstract：:The miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory dermatoses (BID) as previously used to study the miRNA expression profile of tumor-stage mycosis fungoide...

journal_title：Experimental dermatology

authors： Benner MF,Ballabio E,van Kester MS,Saunders NJ,Vermeer MH,Willemze R,Lawrie CH,Tensen CP

更新日期：2012-08-01 00:00:00

abstract：:Exposure of the skin to ultraviolet (UV) irradiation induces photoageing through the up-regulation of matrix metalloproteinases (MMPs) and subsequent breakdown of extracellular matrices. Reactive oxygen species (ROS) and epidermal growth factor receptor (EGFR) activation play central roles in UV-induced MMP expression...

journal_title：Experimental dermatology

authors： Park M,Han J,Lee CS,Soo BH,Lim KM,Ha H

更新日期：2013-05-01 00:00:00

abstract：:Ultraviolet (UV) triggers induction of matrix metalloproteinase-1 (MMP-1) and also induces the rapid appearance of p53 protein in the epidermis and dermal fibroblasts. However, little is known about the role of p53 on MMP-1 expression in human skin. Here, we investigated the effects of p53 on basal and UV-induced MMP-...

journal_title：Experimental dermatology

authors： Kim S,Lee Y,Lee DH,Kim Y,Cho KH,Chung JH

更新日期：2008-11-01 00:00:00

abstract：:The best characterized signalling pathway employed by transforming growth factor-beta (TGF-β) is the Smad pathway. We focused on Smad4, because it is essential for the activation of Smad-dependent target genes. We aimed to explore the possibility of inhibiting scar formation after wounding by blocking TGF-β signalling...

journal_title：Experimental dermatology

authors： Tan WQ,Gao ZJ,Xu JH,Yao HP

更新日期：2011-02-01 00:00:00

abstract：:The role of dendritic cells (DCs) in allergic contact dermatitis has been clearly demonstrated for the induction phase. However, the situation during the elicitation phase is very complex within a distinct inflammatory response. This study was performed to exploit DC migration in the elicitation phase in a mouse model...

journal_title：Experimental dermatology

authors： Bäumer W,Krekeler S,DeVries VC,Niedorf F,Tschernig T,Kietzmann M

更新日期：2006-04-01 00:00:00

abstract：:Optimized delivery of antigens combined with sustainable maturation of dendritic cells (DCs) is crucial for generation of effective antitumoral immune responses. Multiple approaches for ex vivo antigen loading and improvement in immunogenicity have been described. We have recently established a single-step protocol co...

journal_title：Experimental dermatology

authors： Buhl T,Braun A,Forkel S,Möbius W,van Werven L,Jahn O,Rezaei-Ghaleh N,Zweckstetter M,Mempel M,Schön MP,Haenssle HA

更新日期：2014-01-01 00:00:00

abstract：:Dermal white adipose tissue (DWAT) is a main component of human skin, composed of individual lipid-laden mesenchymal cells known as dermal adipocytes (DAs). Besides their well-known role in lipid storage and release, DAs also promote skin immunity, wound healing and hair follicle cycling and are important players in c...

journal_title：Experimental dermatology

authors： Nicu C,Pople J,Bonsell L,Bhogal R,Ansell DM,Paus R

更新日期：2018-06-01 00:00:00

abstract：:Infiltration of eosinophils in atopic dermatitis (AD), which contains inflammatory molecules and cytokines, recruits more inflammatory cells and causes further skin damage. Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine that induces the proinflammatory Th2 immune response and plays an important role in ...

journal_title：Experimental dermatology

authors： Noh JY,Shin JU,Park CO,Lee N,Jin S,Kim SH,Kim JH,Min A,Shin MH,Lee KH

更新日期：2016-11-01 00:00:00

abstract：:Melasma is a frequent pigmentary disorder caused by abnormal melanin deposits in the skin. In vivo reflectance confocal microscopy (RCM) is a repetitive imaging tool that provides real-time images of the skin at nearly histological resolution. As melanin is the strongest endogenous contrast in human skin, pigmentary d...

journal_title：Experimental dermatology

authors： Kang HY,Bahadoran P,Suzuki I,Zugaj D,Khemis A,Passeron T,Andres P,Ortonne JP

更新日期：2010-08-01 00:00:00

abstract：:Although several cytokines and chemokines have been investigated as possible mediators of fibrosis in systemic sclerosis (SSc), specific correlation between cytokines and organ involvement have not been found yet, and a cytokine profile characteristic of SSc is far to be identified. We studied the profile of antifibro...

journal_title：Experimental dermatology

authors： Gonçalves RSG,Pereira MC,Dantas AT,Almeida AR,Rego MJBM,Lima EA,Pitta IDR,Duarte ALBP,Pitta MGDR

更新日期：2019-10-01 00:00:00

abstract：:Inter-α-trypsin inhibitors are protease inhibitors that are thought to be important regulators in various acute-phase processes. They are composed of one light chain (bikunin) and different heavy chains (ITIHs). The only function known so far of ITIHs is the covalent linkage to hyaluronan (HA). As there is virtually n...

journal_title：Experimental dermatology

authors： Huth S,Heise R,Vetter-Kauczok CS,Skazik C,Marquardt Y,Czaja K,Knüchel R,Merk HF,Dahl E,Baron JM

更新日期：2015-09-01 00:00:00

abstract：:Murine model systems are critically required tools for the investigation of unknown mechanisms of melanoma development and metastasis and for developing more efficient therapies. The Tg(Grm1)EPv melanoma mouse model is characterized by spontaneous development of pigmented cutaneous melanomas at hairless skin regions, ...

journal_title：Experimental dermatology

authors： Schiffner S,Chen S,Becker JC,Bosserhoff AK

更新日期：2012-10-01 00:00:00

abstract：:Tetracyclines (TCN) have powerful anti-inflammatory properties in addition to their anti-microbial effects. These anti-inflammatory effects are thought to play a role in inhibiting cutaneous inflammation in patients with rosacea and acne; however, the mechanism(s) of this action remains poorly understood. We have prev...

journal_title：Experimental dermatology

authors： Bender A,Zapolanski T,Watkins S,Khosraviani A,Seiffert K,Ding W,Wagner JA,Granstein RD

更新日期：2008-09-01 00:00:00

abstract：:Pachyonychia congenita type 1 (PC-1) is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy, focal non-epidermolytic palmoplantar keratoderma and variable features of oral leukokeratosis and follicular keratosis. Previously, we have shown that this disease can be caused by mutations...

journal_title：Experimental dermatology

authors： Smith FJ,McKenna KE,Irvine AD,Bingham EA,Coleman CM,Uitto J,McLean WH

更新日期：1999-04-01 00:00:00

abstract：:Nilotinib (AMN), a second-generation tyrosine kinase inhibitor, induces apoptosis in various cancer cells, and our recent study showed that AMN effectively reduced the viability of human ovarian cancer cells via mitochondrion-dependent apoptosis. The effect of AMN in the melanogenesis of melanoma cells is still unclea...

journal_title：Experimental dermatology

authors： Chang SP,Huang HM,Shen SC,Lee WR,Chen YC

更新日期：2018-12-01 00:00:00

abstract：:Epidermolytic hyperkeratosis (EHK) is a genodermatosis caused by mutations in either the keratin 1 (K1) or keratin 10 (K10) genes, and characterized by erythroderma and blistering at birth, with development of a ribbed, ichthyotic hyperkeratosis and palmoplantar keratoderma. A wide variety of mutations within the high...

journal_title：Experimental dermatology

authors： Michael EJ,Schneiderman P,Grossman ME,Christiano AM

更新日期：1999-12-01 00:00:00

abstract：:The immune system is called into action by alarm signals generated from injured tissues. We examined the nature of these alarm signals after exposure of skin residential cells to contact allergens (nickel sulfate and potassium dichromate) and a contact irritant [sodium dodecyl sulfate (SDS)]. Nickel sulfate, potassium...

journal_title：Experimental dermatology

authors： Spiekstra SW,Toebak MJ,Sampat-Sardjoepersad S,van Beek PJ,Boorsma DM,Stoof TJ,von Blomberg BM,Scheper RJ,Bruynzeel DP,Rustemeyer T,Gibbs S

更新日期：2005-02-01 00:00:00

abstract：:The organ culture of human scalp hair follicles (HFs) is the best currently available assay for hair research in the human system. In order to determine the hair growth-modulatory effects of agents in this assay, one critical read-out parameter is the assessment of whether the test agent has prolonged anagen duration ...

journal_title：Experimental dermatology

authors： Kloepper JE,Sugawara K,Al-Nuaimi Y,Gáspár E,van Beek N,Paus R

更新日期：2010-03-01 00:00:00

abstract：:This review focuses on the photoprotection conferred by lycopene, one of the most potent anti-oxidants. Lycopene has been recently proposed to play a critical role on anticarcinogenic action at different levels. The photoprotective properties of lycopene remain contradictory. Some studies point out a positive and othe...

journal_title：Experimental dermatology

authors： Ascenso A,Ribeiro H,Marques HC,Oliveira H,Santos C,Simões S

更新日期：2014-12-01 00:00:00

abstract：:Pemphigus foliaceus (PF) is a severe autoimmune bullous disorder, characterized by autoantibodies (autoAb) against desmoglein 1 (Dsg1). As T cells may be critical in the pathology of PF, the aim of the present study was to identify and characterize autoaggressive T-helper cells reactive to Dsg1 in PF patients and heal...

journal_title：Experimental dermatology

authors： Gebhard KL,Veldman CM,Wassmuth R,Schultz E,Schuler G,Hertl M

更新日期：2005-08-01 00:00:00

abstract：:Human sebaceous gland possesses all the steroidogenic enzymes required for androgen synthesis. It remains unclear whether the testosterone produced in situ mainly derives from circulating dehydroepiandrosterone (DHEA) or from de novo synthesis utilizing serum cholesterol. Using testosterone radioimmunoassay, we found ...

journal_title：Experimental dermatology

authors： Chen W,Tsai SJ,Sheu HM,Tsai JC,Zouboulis CC

更新日期：2010-05-01 00:00:00